ID A0A3B5R0Q5_XIPMA Unreviewed; 685 AA.
AC A0A3B5R0Q5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Collagen type VIII alpha 2 chain {ECO:0000313|Ensembl:ENSXMAP00000036924.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000036924.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000036924.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000036924.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR RefSeq; XP_014326375.1; XM_014470889.1.
DR AlphaFoldDB; A0A3B5R0Q5; -.
DR Ensembl; ENSXMAT00000025184.1; ENSXMAP00000036924.1; ENSXMAG00000029783.1.
DR GeneID; 102235826; -.
DR KEGG; xma:102235826; -.
DR CTD; 1296; -.
DR GeneTree; ENSGT00940000154317; -.
DR OrthoDB; 4267525at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR001073; C1q_dom.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR15427:SF49; C1Q DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR15427; EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER; 1.
DR Pfam; PF00386; C1q; 1.
DR Pfam; PF01391; Collagen; 1.
DR PRINTS; PR00007; COMPLEMNTC1Q.
DR SMART; SM00110; C1Q; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50871; C1Q; 1.
PE 4: Predicted;
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..685
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017405570"
FT DOMAIN 552..685
FT /note="C1q"
FT /evidence="ECO:0000259|PROSITE:PS50871"
FT REGION 51..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..85
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 685 AA; 66965 MW; D497312AA780044E CRC64;
MPVTMLLAPV CLLLMLGGRA FAGGYPPIPH VKYMQPMMKG PVGPPFREGK GHYVDMPPMM
KGEPGPQGKP GPRGPAGPPG LPGKPGLGKP GLTGQPGPQG PPGFTGIGKP GLPGLPGKIG
PNGMPGVNGE VGPRGEPGPR GLPGPPGVPG PAGLSLNGKP GLPGIRGPPG ARGEPGLKGI
SGQPGERGLK GENGNGKPGI PGIRGPPGLK GSTGPPGFPG IGKPGQKGLP GPPGFKGDEG
LPGKLGEPGQ PGPPGLQGLP GPAGLGKPGL DGHPGTPGPV GPKGEQGTRG NPGNPGAPGY
GKPGLNGPKG EKGHGGFPGV PGDKGEQGII GPIGVPGLDG QPGPQGIQGP MGLPGKHGMP
GLKGELGPKG PPGLPGLKGD QGPSGISGRP GFPGEKGISG PNGPIGKPGP KGESGQIGQP
GNPGLTGSPG PKGEVGFIGT PGARGQSGIP GLQGPMGPMG PQGAPGPRGE AGLPGPPGLG
KLGDKGAMGP QGPPGKPGSS GLNGMTGPPG PPGPPGPPGN GQTVAAGGTD AGLGGEEVPG
DRKGPAYTQV LSASLAPAFT AILTTPFPPS SLPIKFDRTL YNGQNAYSTS TGIFTAPLSG
VYYFAYHMHV KGTSLWVALY KNNVPATYTY DEYKKGYMDQ ASGSAVLELK EGDEVWVQMP
SDQANGLYST EYIHSSFSGF LLCPT
//
