ID A0A3B5R1C9_XIPMA Unreviewed; 1483 AA.
AC A0A3B5R1C9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Neurexin-1a-like {ECO:0000313|Ensembl:ENSXMAP00000037433.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000037433.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000037433.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000037433.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSXMAT00000021381.1; ENSXMAP00000037433.1; ENSXMAG00000016119.2.
DR GeneTree; ENSGT00940000154292; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR CDD; cd00053; EGF; 1.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00110; LamG; 6.
DR Gene3D; 2.60.120.200; -; 6.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR003585; Neurexin-like.
DR PANTHER; PTHR15036:SF51; NEUREXIN-1; 1.
DR PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1.
DR Pfam; PF02210; Laminin_G_2; 6.
DR SMART; SM00294; 4.1m; 1.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00282; LamG; 6.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 6.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS50025; LAM_G_DOMAIN; 6.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1483
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017267135"
FT TRANSMEM 1410..1430
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 32..216
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 206..244
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 267..457
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 464..658
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 662..699
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 704..877
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 891..1066
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1069..1106
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1110..1311
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 1316..1345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1370..1400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1450..1483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1467..1483
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1483 AA; 162489 MW; D73F25B508F4AB05 CRC64;
MSVMAVCVWA AAPLLFLGLC LCSVGGQAQG EVLEFGGVSS QWGRFPVWNA CCESVLSFSL
RTQSQEGLLL YLDDEGFCDF LELLLLHGHL RLRFSIFCAG PAELQSGVAV SDGRWHAVRV
KRDWRNTSLE VDGRLEGWAE VKSQRRDMTV LSHTYMGGLP ADLYSSPLHL TSVSVREHHP
AFRGWITAVS INGLLVALNS SEGVTVTTVC GPDHQCQNGG VCSVVNDQAV CDCSDTGYQG
NDCSEEHSHT PGLANLMVGD QAREEYVATF KGSEYFCYDL SPNPIQSSSD EITLSFKTLQ
RNGLMLHTGK SADYVNLALK NGAVSLVINL GSGAFEALVE PVNGKFNDNA WHDVKVTRNL
RQHSGIGHAM VTISVDGILT TTGYTQEDYT MLGSDDFFYV GGSPSTADLP GSPVSNNFMG
CLKEVVYKNN DVRLELSRLA KEGDPKMKVS GVVSFKCESV ATLDPVTFDT PESFVALNKW
MAKKAGSISF DFRTTEPNGL MLFSHGKSRQ QQRKDPRTPP TVKVDFFAIE MLDGHLYLLL
DMGSGTTKTK AIDKKVNDGE WYHVDFQRDG RSGTISVNSV RTAYTAPGDS EILDLDDTLY
LGGLPEDRGG LIFPTEVWTA LLNYGYVGCI RDLFVDGQSK DIRRLAEAQR AVGVKPSCSR
ELPKQCLSNP CQHNGNCREG WNRYVCDCSG TGYLGRSCER DATILSYDGS KFMKVQLPVA
MHTEAEDVSL RFRSQRAYGI LMATTSRNSA DTLRLELDGG RVRLTVNLDC IRINCTASKG
PETIFAGSGL NDNEWHTVRV VRRGKSLKLT VDDLQTVEGQ MAGDHTQLEF HNVETGIVTE
KRFMPIVPSN FIGHLQGLTL NGMPYIDLCK NGDIDYCELN AVIGYKSIVA DPITFRSRSS
FVTLPTLQAY YSMHLFMQFK TTSPDGLILF NRGDGNDFIV IELVKGYLHY ISDLGNGAHL
IKGNSNSPLN DNHWHNVHIS RDTNNLHTVK IDTKVTTQTT MGAKNLDLKG DLYIGGVTKE
MYRELPKLVH SREGFQGCLA TLDLNGRLPD LLADALTTVG QVERGCEGPS TTCQEDSCSN
QGVCLQQWEG FTCDCSMTSY AGPLCNDAGT TYIFGRDGGV VIYTWPPNER PSTRADRLAL
GFSTQQKHAV LLRVDSASGL GDYLQLQIDK GNIRVVFNVG TDDINIEESS KFVNDGKYHV
VRFTRSGGNA TLQLDDLPVI ERYPSGNNDN ERLAIARQRI PYRLGRVVDD WLLDKGRQLT
IFNSQTTVRV GGGEQGSAMF QGQLSGLYYN GLRILNMAAE GHPHIRVEGS ARLVGDMPSS
SITPQSSAAA GANRSDSAPS ISDITTTTAT NKKQVVTQTV DDLLVASAEC PSDDEDIDPC
DSSARPPPPD VKVFPGPSEV VRESSSTTGM VVGIVAAAAL CILILLYAMY KYRNRDEGSY
HVDESRNYIS NSATQPNGSA KDKPLGIAKI SKNKKNKDKE YYV
//
