ID   A0A3B5R551_XIPMA        Unreviewed;       705 AA.
AC   A0A3B5R551;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Collagen type VIII alpha 2 chain {ECO:0000313|Ensembl:ENSXMAP00000038542.1};
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Xiphophorus.
OX   NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000038542.1, ECO:0000313|Proteomes:UP000002852};
RN   [1] {ECO:0000313|Proteomes:UP000002852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA   Walter R., Schartl M., Warren W.;
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000002852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX   PubMed=23542700; DOI=10.1038/ng.2604;
RA   Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA   Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA   Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA   Postlethwait J.H., Warren W.C.;
RT   "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT   evolutionary adaptation and several complex traits.";
RL   Nat. Genet. 45:567-572(2013).
RN   [3] {ECO:0000313|Ensembl:ENSXMAP00000038542.1}
RP   IDENTIFICATION.
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000038542.1};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR   AlphaFoldDB; A0A3B5R551; -.
DR   STRING; 8083.ENSXMAP00000038542; -.
DR   Ensembl; ENSXMAT00000040374.1; ENSXMAP00000038542.1; ENSXMAG00000029783.1.
DR   GeneTree; ENSGT00940000154317; -.
DR   InParanoid; A0A3B5R551; -.
DR   OMA; IPHMKYM; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.40; -; 1.
DR   InterPro; IPR001073; C1q_dom.
DR   InterPro; IPR008160; Collagen.
DR   InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR   PANTHER; PTHR15427:SF49; C1Q DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR15427; EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER; 1.
DR   Pfam; PF00386; C1q; 1.
DR   Pfam; PF01391; Collagen; 2.
DR   PRINTS; PR00007; COMPLEMNTC1Q.
DR   SMART; SM00110; C1Q; 1.
DR   SUPFAM; SSF49842; TNF-like; 1.
DR   PROSITE; PS50871; C1Q; 1.
PE   4: Predicted;
KW   Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          572..705
FT                   /note="C1q"
FT                   /evidence="ECO:0000259|PROSITE:PS50871"
FT   REGION          75..564
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        83..105
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   705 AA;  69284 MW;  F5604C1A34A44698 CRC64;
     MVFNGMNLTQ IYLCVYEKLG MPVTMLLAPV CLLLMLGGRA FAGGYPPIPH VKYMQPMMKG
     PVGPPFREGK GHYVDMPPMM KGEPGPQGKP GPRGPAGPPG LPGKPGLGKP GLTGQPGPQG
     PPGFTGIGKP GLPGLPGKIG PNGMPGVNGE VGPRGEPGPR GLPGPPGVPG PAGLSLNGKP
     GLPGIRGPPG ARGEPGLKGI SGQPGERGLK GENGNGKPGI PGIRGPPGLK GSTGPPGFPG
     IGKPGQKGLP GPPGFKGDEG LPGKLGEPGQ PGPPGLQGLP GPAGLGKPGL DGHPGTPGPV
     GPKGEQGTRG NPGNPGAPGY GKPGLNGPKG EKGHGGFPGV PGDKGEQGII GPIGVPGLDG
     QPGPQGIQGP MGLPGKHGMP GLKGELGPKG PPGLPGLKGD QGPSGISGRP GFPGEKGISG
     PNGPIGKPGP KGESGQIGQP GNPGLTGSPG PKGEVGFIGT PGARGQSGIP GLQGPMGPMG
     PQGAPGPRGE AGLPGPPGLG KLGDKGAMGP QGPPGKPGSS GLNGMTGPPG PPGPPGPPGN
     GQTVAAGGTD AGLGGEEVPG DRKGPAYTQV LSASLAPAFT AILTTPFPPS SLPIKFDRTL
     YNGQNAYSTS TGIFTAPLSG VYYFAYHMHV KGTSLWVALY KNNVPATYTY DEYKKGYMDQ
     ASGSAVLELK EGDEVWVQMP SDQANGLYST EYIHSSFSGF LLCPT
//