ID A0A3B5R6F7_XIPMA Unreviewed; 465 AA.
AC A0A3B5R6F7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=N-acylneuraminate cytidylyltransferase {ECO:0000256|ARBA:ARBA00012491};
DE EC=2.7.7.43 {ECO:0000256|ARBA:ARBA00012491};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000039258.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000039258.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000039258.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an N-acylneuraminate + CTP = a CMP-N-acyl-beta-neuraminate +
CC diphosphate; Xref=Rhea:RHEA:11344, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:37563, ChEBI:CHEBI:60073, ChEBI:CHEBI:68671; EC=2.7.7.43;
CC Evidence={ECO:0000256|ARBA:ARBA00001862};
CC -!- PATHWAY: Amino-sugar metabolism; N-acetylneuraminate metabolism.
CC {ECO:0000256|ARBA:ARBA00005141}.
CC -!- SIMILARITY: Belongs to the CMP-NeuNAc synthase family.
CC {ECO:0000256|ARBA:ARBA00010726}.
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DR AlphaFoldDB; A0A3B5R6F7; -.
DR STRING; 8083.ENSXMAP00000039258; -.
DR Ensembl; ENSXMAT00000034693.1; ENSXMAP00000039258.1; ENSXMAG00000029462.1.
DR GeneTree; ENSGT00390000004237; -.
DR InParanoid; A0A3B5R6F7; -.
DR OrthoDB; 5486419at2759; -.
DR UniPathway; UPA00628; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0006054; P:N-acetylneuraminate metabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd02513; CMP-NeuAc_Synthase; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR003329; Cytidylyl_trans.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR21485; HAD SUPERFAMILY MEMBERS CMAS AND KDSC; 1.
DR PANTHER; PTHR21485:SF3; N-ACYLNEURAMINATE CYTIDYLYLTRANSFERASE; 1.
DR Pfam; PF02348; CTP_transf_3; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT REGION 290..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 465 AA; 51884 MW; 7D8DB97FF7ED98A8 CRC64;
MTARKQKKKG SPKYPKTRHV AALILARGGS KGIPLKNIKP LAGIPLIGWV LRAAIHSDVF
DSVWVSTDHG EIEKVAKSWG AKVHPRSKKV SRNSSTSLET IQEFLKENPE VTVVCNIQAT
SPCIHPFHLK NALKKITEDG YDSVFSVVRR YQFRWKEVEK GSFTEPENLN PAKRPRRQAW
NGELIENGSF YFAPRDLIMK ERRLQGGRVA YFEMKPDHSV DIDVDIDWPV AEQRVLRYGY
FGRGVTVLLR LMFCEVSGCL TKRRGHLSGS LDRPGVSFAG GPCDIDSGVF SDNVSDSEGS
STKSRDTERL SVSIHSSNTE GFSVSIHSRD IEGLRNLQKD DVEVVLVIFE EDVALQHPLT
MIGWEVMMVG KDPLKDVQSM VEKKKLDWKE VAYMGCEAVS ARCLGLAGLS AAPTDAHPKA
IKARKFDCKH GGGAGAVWEF AEDVLLRKRN AVPTSGYNLR QRPRN
//
