ID   A0A3B5RA24_XIPMA        Unreviewed;      1008 AA.
AC   A0A3B5RA24;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Spectrin repeat containing nuclear envelope family member 3 {ECO:0000313|Ensembl:ENSXMAP00000038781.1};
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Xiphophorus.
OX   NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000038781.1, ECO:0000313|Proteomes:UP000002852};
RN   [1] {ECO:0000313|Proteomes:UP000002852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA   Walter R., Schartl M., Warren W.;
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000002852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX   PubMed=23542700; DOI=10.1038/ng.2604;
RA   Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA   Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA   Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA   Postlethwait J.H., Warren W.C.;
RT   "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT   evolutionary adaptation and several complex traits.";
RL   Nat. Genet. 45:567-572(2013).
RN   [3] {ECO:0000313|Ensembl:ENSXMAP00000038781.1}
RP   IDENTIFICATION.
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000038781.1};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the nesprin family.
CC       {ECO:0000256|ARBA:ARBA00008619}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3B5RA24; -.
DR   Ensembl; ENSXMAT00000038677.1; ENSXMAP00000038781.1; ENSXMAG00000024025.1.
DR   GeneTree; ENSGT00440000039367; -.
DR   OMA; ACCLEDQ; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005635; C:nuclear envelope; IEA:UniProt.
DR   Gene3D; 1.20.58.60; -; 3.
DR   InterPro; IPR012315; KASH.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   PANTHER; PTHR47535; MUSCLE-SPECIFIC PROTEIN 300 KDA, ISOFORM G; 1.
DR   PANTHER; PTHR47535:SF2; NESPRIN-3; 1.
DR   Pfam; PF10541; KASH; 1.
DR   SMART; SM01249; KASH; 1.
DR   SMART; SM00150; SPEC; 4.
DR   SUPFAM; SSF46966; Spectrin repeat; 4.
DR   PROSITE; PS51049; KASH; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW   ProRule:PRU00385}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW   ProRule:PRU00385};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TOPO_DOM        1..958
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT   TRANSMEM        959..979
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TOPO_DOM        980..1008
FT                   /note="Perinuclear space"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT   DOMAIN          950..1008
FT                   /note="KASH"
FT                   /evidence="ECO:0000259|PROSITE:PS51049"
FT   REGION          786..819
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          335..362
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1008 AA;  115948 MW;  7650098D14860D1B CRC64;
     MTQQEQQEFT ARLQEADAWM KGIEEQLKAN DNTAGSRDAL EARLRETEKI HSSAHNGRMI
     VDQALMAAEK LLQSGDEELR NSTNIKLKEL KDQWDETTTY ITHCHSRIEW VWLHWSEYLK
     AYEEFELWLA KQRRSLDLDV ELQMGLKEKL WQVEQQMVIV SDIKSQAVLL ERLLDEAAAL
     HSRTEDPSVD AKAQQRLQED YVEVRDRAQE RLMLLQKFSE EHRMFHSHVQ KFQSWLVSKT
     KELTELMKLE ETPENKLRAL KTVDENVDCE EKTLQHIEGM ADAVRANTSP AGAEAVQEEA
     EELRLGWQRL RQGLCEAEEG LRCSLDSHSQ YATRCQRLGD EIGRIREMLQ ELDQELVDTQ
     ESKSCKEMTE EQMEGRWRKY SGVRNTLAGK ETQVDLLKSQ LKDLFRFSED PRHLTDGVLA
     VVKEHQSVKS RASRLCSESE LELRSLLQDP LLSFSQWANS VSQVMEASNN VNDFSNTAML
     LQKIQGLLQK STELQERLSL LQVKGDLLDS VFGTESSDDL QGELSAAVRT RELLHNQLLE
     RKNRLESLIS RTKDFDEAYK QILATLSAFR ERLLAADVLQ PDILAKKSQL EQMLVLQKEL
     EDGEAQLTVL DTLVSSNQSS RTQYEKLCAD WSELHRRVTV KVQDCDDIVS DHECFHGDLL
     NMEKWIMVMR QKLDSFCSPT GGWSVEGRRP EAQKLLGEFP EKELHLQQIE AQGGKVLRRT
     STDGRVHIQK DLERLRQRWN DLLTLSLNLN RLQGGSTEIH SGSAASFGRF KSEPDHIMQV
     VDLSGTCQTD GPRRRLTAGR EGSEATASSS GEDDSRGSRD LNQINWREFE AWLSRENEVL
     MKITRTDKSS LSAEEIRTRR GTLQALISRL PEGQQMFQLL LQQTQSSQGE DETLENLRYR
     WTLYKSKLKE VENNLIMTKP GLEERKELEL RRGAENVKGT VSETRTEKKR GLLYRICRLA
     LLLWLLFLAL LLLAFLLPLM DDGNSCSLSN NFARSFNVML RYDGPPPT
//