ID A0A3B5RBI3_XIPMA Unreviewed; 1553 AA.
AC A0A3B5RBI3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Adhesion G protein-coupled receptor L2 {ECO:0000313|Ensembl:ENSXMAP00000039231.1};
GN Name=ADGRL2 {ECO:0000313|Ensembl:ENSXMAP00000039231.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000039231.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000039231.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000039231.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR STRING; 8083.ENSXMAP00000039231; -.
DR Ensembl; ENSXMAT00000032931.1; ENSXMAP00000039231.1; ENSXMAG00000017908.2.
DR GeneTree; ENSGT00940000156348; -.
DR InParanoid; A0A3B5RBI3; -.
DR OMA; XTASYLC; -.
DR OrthoDB; 1114672at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0071603; P:endothelial cell-cell adhesion; IEA:Ensembl.
DR GO; GO:0035331; P:negative regulation of hippo signaling; IEA:Ensembl.
DR GO; GO:0043114; P:regulation of vascular permeability; IEA:Ensembl.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd22845; Gal_Rha_Lectin_LPHN2; 1.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.120.740; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR003924; GPCR_2_latrophilin.
DR InterPro; IPR003334; GPCR_2_latrophilin_rcpt_C.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000922; Lectin_gal-bd_dom.
DR InterPro; IPR043159; Lectin_gal-bd_sf.
DR InterPro; IPR003112; Olfac-like_dom.
DR PANTHER; PTHR12011:SF61; ADHESION G PROTEIN-COUPLED RECEPTOR L2; 1.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF02140; Gal_Lectin; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF02793; HRM; 1.
DR Pfam; PF02354; Latrophilin; 1.
DR Pfam; PF02191; OLF; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01444; LATROPHILIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00284; OLF; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51132; OLF; 1.
DR PROSITE; PS50228; SUEL_LECTIN; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00446};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1553
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017326334"
FT TRANSMEM 879..900
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 912..930
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 942..966
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 978..997
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1017..1040
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1086..1108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1114..1137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 42..131
FT /note="SUEL-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50228"
FT DOMAIN 161..420
FT /note="Olfactomedin-like"
FT /evidence="ECO:0000259|PROSITE:PS51132"
FT DOMAIN 494..551
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 873..1138
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 461..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1341..1384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1440..1487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..489
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1444..1478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 162..344
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00446"
SQ SEQUENCE 1553 AA; 174809 MW; 1691DAA75B52D67A CRC64;
MACSLRTLHT FCWFLITLNQ VHSTEGFSRA ALPFGLVRRE LSCEGYPIDL RCPGSDVIMI
ESANYGRTDD KICDADPFQM ENINCYLPDA YKIMSQRCNN RTQCIVITGS DVFPDPCPGT
YKYLEVQYEC VPYSPCPTRI GSRAQNVSYH NCPEVEQKVF LCPGTLKAVG DPSFRFEVEQ
QAGAWCKDPL QAGDKIYFMP WTPYRTDTLI EYSSLDDVQN ARQTITYKLP HRVDGTGFVV
YDGAVFFNKE RTRNIVKFDL RTRIKSGEAI INNANYHDTS PYKWGGKTDI DLAVDENGLW
VIYATEQNNG MMVISQLNPY TLRFEATWET AYDKRSASNA FMVCGVLYVV RSTYEDNESE
VSKSLIDYIY NTKQNHGEFV DIHFPNQYQY IAAVDYNPRD NQLYVWDNFY VLRYNLEFGP
PDPAHAPPLS EVTTATQPQR TTTVTTTTTA HWGAANTTTT VLKEGSRRAP KPPPVIPQTT
SPPPLESFPL PERFCKATEK RDIMWPQTQR GMLVERPCPK GTRGTASYLC LLSTGDWHPK
GPDLSNCTSH WVNQLAQKIR SGENAANLAN ELAKHTKGPI FAGDVSSSVR LMEQLVDILD
AQLQEYRPSE KDSAGRSFNK LQKRERTCRA YMKAMVDTVD NLLRPEALKS WHDMNSTEQT
HAATMLLDTL EEGAFVLADN LMEPAIVKVP ADNIILDVYV LSTDGQVQDF KFPQSSKSGI
SIQLSANTVK LNSRNGVAKL VFVLYKNLSQ FLGTENATIK MANEAYGRNV TVAVNSDIIA
ASINKESSRV FINDPVIFTL QHIDMEHYFN SNCSFWNYSE RSMMGYWSTQ GCKLLDSNKT
HTTCACSHLT NFAILMAHRE ISGSVRDHHE LLLTVITRVG IVVSLVCLTI CIFTFCFFRG
LQSDRNTIHK NLCINLFIAE LIFLIGIDMT EPRIGCAIIA GILHFFFLAS FSWMCLEGVQ
LYLMLVEVFE SEYSRKKYYY VSGYLFPAIV VGVSAAIDYG SYGTHKACWL SVDNHFIWSF
IGPVTFIIML NLIFLVITMY KMVKHSTTLK PDSSRLENIN NYRVCDGYYN TDLPGYEDNK
HFIKSWVMGA FALLCLLGLT WSFGLFFISE ASIVMAYLFT IFNTFQGMFI FIFHCLLQKK
VRKEYSKCFR HTYCCRGLPT ESSHGSTKTS TTRTSARYSS GTQVDQQLYT SRIRRMWNDT
VRKQSESSFI SGDINSTSTL NQGMTGNYLL TNPLLRPQGT NNPYNTLLAE TVVCNTPTAP
VFNSPVTFRE TRHSLNSAVR DTSAMDTLPL NGNFNNSYSL RNGDFGDSVQ VVDCGLSLDD
AAFEKMIISE LVHNNLRACN KSHQQQQHSS LRHPPHRQQL PPPQYHHHHH TERAPPKVTV
VGGSSSEDDA IVADTSSLVH MGNAVGLELH HQQELEAPLI PQRTHSLLYA PQKKVRTDGG
VDTFVSPLTP TNPDDSAQSP NRDSLYTSMP NITDSPCPES SPDVVEDVSP IKGSENEDVY
YKSMPNLGAG HQLQAYYQIG RGSSDGYIIP VTKEDCIPEG DVQEGQMQLV TSL
//
