ID A0A3B5RBV9_XIPMA Unreviewed; 1232 AA.
AC A0A3B5RBV9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=IQ motif and SEC7 domain-containing protein 1-like {ECO:0000313|Ensembl:ENSXMAP00000041278.1};
GN Name=IQSEC1 {ECO:0000313|Ensembl:ENSXMAP00000041278.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000041278.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000041278.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000041278.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the BRAG family.
CC {ECO:0000256|ARBA:ARBA00006248}.
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DR AlphaFoldDB; A0A3B5RBV9; -.
DR STRING; 8083.ENSXMAP00000041278; -.
DR Ensembl; ENSXMAT00000023718.1; ENSXMAP00000041278.1; ENSXMAG00000007488.2.
DR GeneTree; ENSGT00940000156915; -.
DR InParanoid; A0A3B5RBV9; -.
DR OMA; AGHSAHH; -.
DR OrthoDB; 204547at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR GO; GO:0001946; P:lymphangiogenesis; IEA:Ensembl.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd13318; PH_IQSEC; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR033742; IQSEC_PH.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF398; IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 1-LIKE; 1.
DR Pfam; PF16453; IQ_SEC7_PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT DOMAIN 624..817
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 365..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 420..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 484..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 988..1013
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1029..1232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 24..65
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 427..448
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 498..512
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..528
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..550
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..605
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 991..1013
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1080..1095
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1104..1118
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1217..1232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1232 AA; 138914 MW; 2D21CA605DE426FC CRC64;
MDGQRILAEM ENPTENPSKA AEYLQELNNI IETQQVLLEK QRIRIEELEL QVTDLCKENA
CLKDQHRRHL TTCGLAQGNP GTLGGIEENV VQEKRHASLP ARVFEIHQNV FDPLCRTSYP
CLKWKSASFG VEGDAPGSDV SVSVDPCVIY GCKPVTHGGR PGLDYLDSQL YGHIFLPSHV
RPRRPKLQHS QSILRKHAEE EAIKRSRSMS ESYELSSDLQ DKQVEMLERK YGGRFITRHA
ARTIQTAFRQ YQMNKNFERL RSSMSENRMS RRIVLSNMRM QLSFEGPEKV HSSYFEGKHL
SLSDEGANIG ALVQSEHGRE RGVQMKIPST QSDLTYAVTE LEDAFSRQVK SLAESIDDAL
NCRSLHGEDS TSEQGRSHPD TDRELSRQLE SSHSPSDHRK LDEMTASYSD VTLYIDEEEL
SPPLPLSQSV DRPSSTESDL RQRSLNSSQD YWSLAHKDEK GDTDTSCRST PSLECQEQRL
RVDHLPLLTI EPPSDSSVEL SDRSDRSSLK RQSTYDRSPS NQQSSPKHIG HGLPPRGPSR
EEDPSRHCAR QLEAHLAING TPNRQSKSES DFSDGDNDSI NSTSNSNDTI NCSSESSSRD
SLREQTLSKQ TYHKETRNSW DSPAFSNDII RKRHYRIGLN LFNKKPEKGI QYLIERSYVP
DTPVGVAHFL LQRKGLSRQM IGEFLGNRQK QFNRDVLDCV VDEMDFSGLE LDEGLRKFQA
HIRVQGEAQK VERLIEAYSQ RYCICNPGVV RQFRNPDTIF ILAFAIILLN TDMYSPNVKP
ERKMKLEDFV KNLRGVDDGE DIPREMLVGI YERIRKRELR TNEDHVSQVQ KVEKLIVGKK
PIGSLHQGLG CVLSLPHRRL VCYCRLFEVP DPNKLQKLGL HQREIFLFND LLVVTKIFQK
KKNSVTYSFR QSFSLYSMQV LLFENQYYPN GLRLTSAIPG ADIKVLINFN APNPQDRKRF
TDDLRESIAE VQEMEKYRIE TELEKQKGLV RPSMSQCSGL KKETGNGNLS RASLDDSYAI
GEGLKRSALS SSLRDLSDAG KRGRRSSAGS LDSNLEGSII SSPHMRRRTP SGRDCASRHS
GHSLPSSSSL LGSLFGTRRV RSPGPCPGPV PQSPHPTLIS HAPHPANLHH AARAESDSSV
PVHPHPVPFC HVTQNPPPYH HHHHYHPPPH LQRAPHQCHA PPSHSQHPPY PQHSHGSHSA
HGGHLHGPPP TPASQVPSSS TKPKHSGIST VV
//
