ID A0A3B5RC01_XIPMA Unreviewed; 1372 AA.
AC A0A3B5RC01;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Nuclear receptor coactivator 2-like {ECO:0000313|Ensembl:ENSXMAP00000039381.1};
GN Name=NCOA2 {ECO:0000313|Ensembl:ENSXMAP00000039381.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000039381.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000039381.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000039381.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SRC/p160 nuclear receptor coactivator
CC family. {ECO:0000256|ARBA:ARBA00009933}.
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DR Ensembl; ENSXMAT00000022224.1; ENSXMAP00000039381.1; ENSXMAG00000006493.2.
DR GeneTree; ENSGT00950000183021; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0016922; F:nuclear receptor binding; IEA:InterPro.
DR GO; GO:0030374; F:nuclear receptor coactivator activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 6.10.140.410; -; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR010011; NCO_DUF1518.
DR InterPro; IPR032565; NCOA2/3_DUF4927.
DR InterPro; IPR009110; Nuc_rcpt_coact.
DR InterPro; IPR014920; Nuc_rcpt_coact_Ncoa-typ.
DR InterPro; IPR037077; Nuc_rcpt_coact_Ncoa_int_sf.
DR InterPro; IPR017426; Nuclear_rcpt_coactivator.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR014935; SRC/p160_LXXLL.
DR PANTHER; PTHR10684; NUCLEAR RECEPTOR COACTIVATOR; 1.
DR PANTHER; PTHR10684:SF2; NUCLEAR RECEPTOR COACTIVATOR 2; 1.
DR Pfam; PF16279; DUF4927; 1.
DR Pfam; PF08815; Nuc_rec_co-act; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR Pfam; PF08832; SRC-1; 1.
DR PIRSF; PIRSF038181; Nuclear_receptor_coactivator; 2.
DR SMART; SM01151; DUF1518; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF69125; Nuclear receptor coactivator interlocking domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 27..84
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 120..184
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 524..576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 610..642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 768..794
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 807..873
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1048..1093
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1193..1276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1291..1334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..416
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..483
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..563
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 846..873
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1048..1074
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1194..1226
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1372 AA; 147886 MW; 96ECDB8C4F56AF7C CRC64;
MSSGGGDTPE PPKGESVKRK DCQSDLLGPS PKRSTERRNR EQENKYIEEL AELIFANIND
IDDLNVKPDK CAILKETVKQ IRQIKEQEKT LVTNAEEVQK ADVSSTGQAV IDKDTLGPMM
LEALDGFFFV VNMEGNIVFV SENVSQYLRY QQEELMNTSV YSVLHVGDHA EFIKNLLPKS
LVNHRSTDSS NRNSHTFNCR MLVNPHADGE ARQAVDQQDA AQQKYETMQC FAVSEPKSIK
EEGEDFQSCL ICVARRVPVK ERPVMPAYES FTTRQDLQGK ITSLDTSVLR ASMKPGWEDL
VRRCIQKFHL QSDGEISFAK KHQQEVLKNG HALSPLYRFS LADGTIVSAH TKSKLVRSPV
LYQTPTENHI WEYYIPSGQD SGKSMTPTSM SGSFPSPDAS VTSNSHHSTG ASTTPGRGFG
SVPGRAITPQ GNSHTLKLGS PSGQGSPSVS SGVQSAMLSP RHRQSPSAAA NSSNCSSPHL
LQHPPGSFSP AAGLHSPPSV CSTTGNNQSF NSLSALQALS QGARISPGLS DGQHPESPDR
KPAALQSNLH SNKPEFLSSH THDGTQADGK DVDPDTLGVN GNLGDLADAA NHHLTTKGHT
KLLQLLTTKL EPSDPSSPPG PIGDDQNCKD QMCGGAGHNN QTTSLKEKHK ILHRLLQNST
SPVELAKLTA EATGKDPIGP ESASGDSMAA LSELCTKQEP GSQGKKDNAL LRYLLDRDDN
GILDKAIKME PSDGLKLTCV KTEKQDEGFN LAEQASELED LLEDLQNSSQ QQLFPSQPPS
SSSSSSAVPA GSSVDKQTII SDILQMNDTS SSSSPSQHRA FPPIGAAASF NGVRPGQAGQ
GAPPGRSMSL DSSMGSSPTR PFPPQHRNNG PYSLQQQGMM GTHTSMNQAA VTNTGLRSSM
QQAWGPHAPT GGSAGPMMAH GVGRMVPNMN SALPPRSTGP NVSRALVSMQ MMGNELDMAT
PPYHQQQVPP NQTAPWPDRM MMMDHYGNQS RPPYGVRQED GISCCGSEGQ TDEGALLNQL
CSVLKDYEGL EEIDKMLGIP TLAGQVNQDQ YLGPSDSPSS LKPPLYSQQY GGQPSYGGMP
PDGLYPAPSM GGQMGPQRMA PAGYPPMMRM PGSPVPRAPG MRPSGPNPMV PPQPNNLRLQ
LQHRLQAQLN RQPVMNQMGG VGNMNLPLRS NVSTQGPVNA HMLAQRQREY LSNHLRQRQQ
QQQQQQHHVH QQRAMMMRTQ GINLPPNMPS GGAAPSPMPM GGANTRVPQG SMQRFPYPAS
GYGMSQQQHQ DPASCFPCGA GTPQSPLLSP RMGQGQSPML QQNQGQTYQT SADLNGWSQP
QSQSQYSTQS SGMYSSSNMN LGVTMASSSN MNSVAGQMGS MNEQVTKSLF HI
//
