ID A0A3B5RCJ7_XIPMA Unreviewed; 2065 AA.
AC A0A3B5RCJ7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Dedicator of cytokinesis 3 {ECO:0000313|Ensembl:ENSXMAP00000040724.1};
GN Name=DOCK3 {ECO:0000313|Ensembl:ENSXMAP00000040724.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000040724.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000040724.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000040724.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR Ensembl; ENSXMAT00000022888.1; ENSXMAP00000040724.1; ENSXMAG00000009900.2.
DR GeneTree; ENSGT00940000155514; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08695; C2_Dock-B; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR037811; C2_Dock-B.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF4; DEDICATOR OF CYTOKINESIS PROTEIN 3; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 6..67
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 421..599
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1214..1621
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 188..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1673..1703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1829..1916
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1673..1702
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1848..1912
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2065 AA; 237190 MW; 7B5D48232B41395E CRC64;
MWTPTEDEKI GVVICNFRGS VTQGLALEVG ETVQILEKFE GWYRGFSTRK PNVKGVFPAS
YIHLKKAIVT NRGPHETVVP LEDPIVTEVT LTLQEWALLW KQLYVKHKVD LFYKVRHVMM
ELIDLRRQLL SGHLTQDQSR DVKRHITVRL DWGNEHLGLD LVPRKEFEMV DEDQISVSDL
YKMHLSSRHS VQQSNTQGEN SRQRHGEPCR VPVPHHLLVN LKSFTYNSIG EDTDIFFSLY
DLREGKTISE KFMVRLNKNG GPKNPEKVDR LCALFTDLSN KDMKRELYIV SQVIRTGRML
LNDSKKGPPH VQYRRPHGCA VLAMSDVLQI ISELKEEKDF VLKVYTCNNE NEWYQIHENI
IRKSSTKYTA PSTNYGLIIS LQLLRGDMEQ VRRENPLIFS RGVAITRKLG FPDVIMPGDI
RNDLYLTLER GDFERGGKSV QKNIEVTMYV IYADGEVLKD CISLGSGEPN IPEYRSFVLY
HNNSPRWSEV IKLPIPIDRF RGSHLRFEFR HCSTKDKGEK KLYGFAFTPL MREDGTTLSD
ESHELYVYKC DENTTFSNHA LYLGLPCCKD DFNSCPNIPS SLIFQRSTKE TFWIATQLSS
TKLTQNVDLL ALLKWKAHPD QVMDILGRLR HVSGEEIVKF LQDILDTLFS ILDDNTDKYG
PLVFQSLVFI INLLRDSKYY HFRPVMDTYI QKHFAGALAY KELIRCLKWY MDRSAEVVRQ
DHIQEAMRAL EYLFKFIIQS RILYSRATCG MEEEQFRTSI QELFQSIRFV LSLDSRNSET
LIFTQAALLN SFPAIFDELL QMFTVQEVAE FVRGTLGSMP STVHIGQSMD VVKLQSIART
VDSRLFSFPE SRRILLPVVL HHIHLHLRQQ KELLICSGIL SSIFSIIKSS SLDTSVQEEV
EMMVESLLDV LLQTLLSIMS KSQSQEAGEY VSCLLSLLRQ MTDIHFQHLM ENFQSKDELK
EFLLKILCVF RNLMKLSIFP RDWNIMRLLT SNIILTTAQQ LAPALHKNFA EADFDFKVWN
SYFSLAVLYI NQPSLQLENL SPSKRKKILD KYGDMRVMMT YELFNMWQNL GENKIHFIPG
MIGPFLGVTL VPQVEVRNIM IPIFHDMMDW EQRKNGNFKQ VEAELIDKLD SLVSEGKGDE
NYRELFGLLT QLFGPYPSLL EKIEQETWRE TGISFVTSVT RLMERLLDYR DCMKGDETEN
KKIGCTVNLL NFYKSEINKE EMYIRYIHKL CDMHLQAENY TEAAFTLLLY WELLHWDERP
VKEFLHYPAQ TEWHRKEGLC RKVIHYFNKG KCWEYGIPLC RELAFQYESL YDYQSLSWIR
KMEAAYYDNI MEQQRLEPEF FRVGFYGRKF PFFLRNKEFV CRGHDYERLE AFQQRMLGEF
PQAIAMQHPN QPDEAILQCD AQYLQIYAVT PVPESVTVLQ MDRVPDRIKS FYRVNNVRRF
RYDRPFHKGL KDRDNEFKSL WIERTTLILT HPLPGISRWF EVDKRELVEV SPLENAISVV
ENKNQELRTL ISQYQHKQLH GNINLLSMTL NGVIDAAVNG GIARYQEAFF DKEYITSHPE
DTEKITQLKD LMQEQVHILG VGLAVHEKLV HPEMRPLHKK LIDQFQMMRS SLCHGPPGFD
KSGSGVNRGI LASHNPMSPE SFKLVHRHSE AGNLLILADG VVVEHPEDFY RMQASPSSSS
LSSTHSAPSQ MINSTPSTMR VGSPSLPDKY RHNREMLMLL PPHRERPSSA MYSNITENGQ
PPNFQRALFH QVIGPCKPCS DPNLSVVEKV LTTPSSWSLD SGTREALPFL SSHVGSVMAP
PVPPRNIPHG QHLSMHFDAF HHQVSDLPPA LPARSLRKSP LHPIPASPTS PQSVLDGSNS
TLSGSASSGV SSLSESNFGG ATSSSDPPAS RTDTLESVPS SQAWTTDQED LDSPYQPVRY
SMSESDVVEG VKSPPCRSNS APGGVNPALV GYQIQPQAAG LGCTGAPQPD GLQQQQHQFY
HHHFHPHYIP HNPPLYHLHE PPPALPPKPY LREGCIPEED PLIAQSGPPR PAVPRPMPRK
ISQPIIAATK DEQAKVAWEH GISEE
//
