ID A0A3B5Y023_WHEAT Unreviewed; 465 AA.
AC A0A3B5Y023;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Pyruvate kinase {ECO:0000256|ARBA:ARBA00012142, ECO:0000256|RuleBase:RU000504};
DE EC=2.7.1.40 {ECO:0000256|ARBA:ARBA00012142, ECO:0000256|RuleBase:RU000504};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS1A02G213000.1};
RN [1] {ECO:0000313|EnsemblPlants:TraesCS1A02G213000.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS1A02G213000.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS1A02G213000.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate;
CC Xref=Rhea:RHEA:18157, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58702, ChEBI:CHEBI:456216;
CC EC=2.7.1.40; Evidence={ECO:0000256|ARBA:ARBA00001174,
CC ECO:0000256|RuleBase:RU000504};
CC -!- COFACTOR:
CC Name=K(+); Xref=ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00001958};
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-
CC glyceraldehyde 3-phosphate: step 5/5. {ECO:0000256|ARBA:ARBA00004997,
CC ECO:0000256|RuleBase:RU000504}.
CC -!- SIMILARITY: Belongs to the pyruvate kinase family.
CC {ECO:0000256|ARBA:ARBA00008663, ECO:0000256|RuleBase:RU000504}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3B5Y023; -.
DR SMR; A0A3B5Y023; -.
DR STRING; 4565.A0A3B5Y023; -.
DR PaxDb; 4565-Traes_1AL_0815BD32E-1; -.
DR EnsemblPlants; TraesCS1A02G213000.1; TraesCS1A02G213000.1; TraesCS1A02G213000.
DR Gramene; TraesCAD_scaffold_040565_01G000300.1; TraesCAD_scaffold_040565_01G000300.1; TraesCAD_scaffold_040565_01G000300.
DR Gramene; TraesCLE_scaffold_086366_01G000100.1; TraesCLE_scaffold_086366_01G000100.1; TraesCLE_scaffold_086366_01G000100.
DR Gramene; TraesCS1A02G213000.1; TraesCS1A02G213000.1; TraesCS1A02G213000.
DR Gramene; TraesCS1A03G0560800.1; TraesCS1A03G0560800.1.CDS; TraesCS1A03G0560800.
DR Gramene; TraesPAR_scaffold_127057_01G000100.1; TraesPAR_scaffold_127057_01G000100.1; TraesPAR_scaffold_127057_01G000100.
DR Gramene; TraesROB_scaffold_120997_01G000300.1; TraesROB_scaffold_120997_01G000300.1; TraesROB_scaffold_120997_01G000300.
DR Gramene; TraesWEE_scaffold_093451_01G000100.1; TraesWEE_scaffold_093451_01G000100.1; TraesWEE_scaffold_093451_01G000100.
DR OMA; TAYKGHM; -.
DR UniPathway; UPA00109; UER00188.
DR Proteomes; UP000019116; Chromosome 1A.
DR GO; GO:0009570; C:chloroplast stroma; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030955; F:potassium ion binding; IEA:InterPro.
DR GO; GO:0004743; F:pyruvate kinase activity; IBA:GO_Central.
DR GO; GO:0006096; P:glycolytic process; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.60; Phosphoenolpyruvate-binding domains; 1.
DR Gene3D; 2.40.33.10; PK beta-barrel domain-like; 1.
DR Gene3D; 3.40.1380.20; Pyruvate kinase, C-terminal domain; 1.
DR InterPro; IPR001697; Pyr_Knase.
DR InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR InterPro; IPR040442; Pyrv_Kinase-like_dom_sf.
DR InterPro; IPR011037; Pyrv_Knase-like_insert_dom_sf.
DR InterPro; IPR018209; Pyrv_Knase_AS.
DR InterPro; IPR015793; Pyrv_Knase_brl.
DR InterPro; IPR015795; Pyrv_Knase_C.
DR InterPro; IPR036918; Pyrv_Knase_C_sf.
DR InterPro; IPR015806; Pyrv_Knase_insert_dom_sf.
DR NCBIfam; TIGR01064; pyruv_kin; 1.
DR PANTHER; PTHR11817:SF63; PLASTIDIAL PYRUVATE KINASE 3, CHLOROPLASTIC; 1.
DR PANTHER; PTHR11817; PYRUVATE KINASE; 1.
DR Pfam; PF00224; PK; 1.
DR Pfam; PF02887; PK_C; 1.
DR PRINTS; PR01050; PYRUVTKNASE.
DR SUPFAM; SSF51621; Phosphoenolpyruvate/pyruvate domain; 1.
DR SUPFAM; SSF50800; PK beta-barrel domain-like; 1.
DR SUPFAM; SSF52935; PK C-terminal domain-like; 1.
DR PROSITE; PS00110; PYRUVATE_KINASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Glycolysis {ECO:0000256|ARBA:ARBA00023152, ECO:0000256|RuleBase:RU000504};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU000504};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU000504};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Pyruvate {ECO:0000256|ARBA:ARBA00023317};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000504}.
FT DOMAIN 2..305
FT /note="Pyruvate kinase barrel"
FT /evidence="ECO:0000259|Pfam:PF00224"
FT DOMAIN 353..444
FT /note="Pyruvate kinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02887"
SQ SEQUENCE 465 AA; 51187 MW; 37AEC8C13060D7FD CRC64;
MIWKLAETGM NVARMNMSHG DHQSHQKVID LVKEYNAENT DGNTIAIMLD TKGPEVRSGD
LPEPIMLAEG QEFNFTIKRG VSTEDTVSVN YDDFISDVEA GDILLVDGGM MSLAVKLKTA
DTVKCVVVDG GELKSRRHLN VRGKSATLPS ITEKDWEDIK FGVENGVDFY AVSFVKDAKV
IHELKAYLKS ANADIHVIPK IESADSIPNL QSIIAASDGA MVARGDLGAE LPIEEVPLLQ
EEIIRTCRSM QKPVIVATNM LESMIDHPTP TRAEVSDIAI AVREAADAIM LSGETAHGKY
PLKAVKVMHT VALRTESSLY DPAKAPSLVA RPKALLNDDF CKSQLSKMFG SHATMMANTL
RTPIIVFTRV GSMAVLLSHY RPSSTVYAFT NEVRVKQRLA LYQGVVPILM EFSDDAEETF
SRAITSLLDA KYMNEGDYVT LVQSGSQSIW REESTHHIQV RKVQC
//
