ID A0A3B5ZX82_WHEAT Unreviewed; 322 AA.
AC A0A3B5ZX82;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Sphingomyelin synthase-like domain-containing protein {ECO:0000259|Pfam:PF14360};
GN ORFNames=CFC21_012530 {ECO:0000313|EMBL:KAF6996155.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS1D02G279500.1};
RN [1] {ECO:0000313|EMBL:KAF6996155.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF6996155.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS1D02G279500.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS1D02G279500.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS1D02G279500.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF6996155.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF6996155.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sphingomyelin synthase family.
CC {ECO:0000256|ARBA:ARBA00005441}.
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DR EMBL; CM022213; KAF6996155.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B5ZX82; -.
DR STRING; 4565.A0A3B5ZX82; -.
DR EnsemblPlants; TraesCS1D02G279500.1; TraesCS1D02G279500.1; TraesCS1D02G279500.
DR Gramene; TraesCAD_scaffold_058707_01G000100.1; TraesCAD_scaffold_058707_01G000100.1; TraesCAD_scaffold_058707_01G000100.
DR Gramene; TraesCLE_scaffold_090334_01G000100.1; TraesCLE_scaffold_090334_01G000100.1; TraesCLE_scaffold_090334_01G000100.
DR Gramene; TraesCS1D02G279500.1; TraesCS1D02G279500.1; TraesCS1D02G279500.
DR Gramene; TraesCS1D03G0672600.1; TraesCS1D03G0672600.1.CDS; TraesCS1D03G0672600.
DR Gramene; TraesKAR1D01G0272110.1; cds.TraesKAR1D01G0272110.1; TraesKAR1D01G0272110.
DR Gramene; TraesPAR_scaffold_059965_01G000100.1; TraesPAR_scaffold_059965_01G000100.1; TraesPAR_scaffold_059965_01G000100.
DR Gramene; TraesRN1D0100715400.1; TraesRN1D0100715400.1; TraesRN1D0100715400.
DR Gramene; TraesROB_scaffold_015246_01G000300.1; TraesROB_scaffold_015246_01G000300.1; TraesROB_scaffold_015246_01G000300.
DR Gramene; TraesWEE_scaffold_055506_01G000100.1; TraesWEE_scaffold_055506_01G000100.1; TraesWEE_scaffold_055506_01G000100.
DR OMA; REDSKIW; -.
DR OrthoDB; 67418at2759; -.
DR Proteomes; UP000019116; Chromosome 1D.
DR Proteomes; UP000815260; Chromosome 1D.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR GO; GO:0047493; F:ceramide cholinephosphotransferase activity; IBA:GO_Central.
DR GO; GO:0045140; F:inositol phosphoceramide synthase activity; IBA:GO_Central.
DR GO; GO:0033188; F:sphingomyelin synthase activity; IBA:GO_Central.
DR GO; GO:0046513; P:ceramide biosynthetic process; IBA:GO_Central.
DR InterPro; IPR045221; Sphingomyelin_synth-like.
DR InterPro; IPR025749; Sphingomyelin_synth-like_dom.
DR PANTHER; PTHR21290:SF49; OS05G0452900 PROTEIN; 1.
DR PANTHER; PTHR21290; SPHINGOMYELIN SYNTHETASE; 1.
DR Pfam; PF14360; PAP2_C; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Sphingolipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 78..99
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 223..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 172..240
FT /note="Sphingomyelin synthase-like"
FT /evidence="ECO:0000259|Pfam:PF14360"
FT REGION 251..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..311
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 322 AA; 37070 MW; E1398FBEE24AF59E CRC64;
MTIYLAREAS KVWRKVCAET TTELPLLREK WPLLLAGIVF QYIHGLAARG VHYLHRPGPL
LQDLGFMALP ELGQDKNYLS ECTFVFIFFS FFLWTFHPFI YHSKRFYTIL IWRRVLAFLV
ASQVLRIITF YSTQLPGPNY HCREGSNMAT LPPPNNVLEV LLINFPRGVN LGCGDLIFSS
HMIFTLVFVR TYHKYGSKRF IKLLAWVMAI VQSLLIIAAR KHYTVDVVVA WYAVNLVVFF
VDTKLPEMPD RTNGSPLIPL SNKDKDGRPK DEKDVRLKDE FHKLLNGNHG DPTDRRQRVQ
MNGRHPEEDM SMLSDATPNG GT
//
