ID   A0A3B6A0W2_WHEAT        Unreviewed;       647 AA.
AC   A0A3B6A0W2;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=EF-hand domain-containing protein {ECO:0000259|PROSITE:PS50222};
OS   Triticum aestivum (Wheat).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX   NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS1D02G350600.2};
RN   [1] {ECO:0000313|EnsemblPlants:TraesCS1D02G350600.2}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Chinese Spring
RC   {ECO:0000313|EnsemblPlants:TraesCS1D02G350600.2};
RX   PubMed=30115783; DOI=10.1126/science.aar7191;
RG   International wheat genome sequencing consortium (IWGSC);
RT   "Shifting the limits in wheat research and breeding using a fully annotated
RT   reference genome.";
RL   Science 361:EAAR7191-EAAR7191(2018).
RN   [2] {ECO:0000313|EnsemblPlants:TraesCS1D02G350600.2}
RP   IDENTIFICATION.
RG   EnsemblPlants;
RL   Submitted (OCT-2018) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A3B6A0W2; -.
DR   EnsemblPlants; TraesCS1D02G350600.2; TraesCS1D02G350600.2; TraesCS1D02G350600.
DR   Gramene; TraesCS1D02G350600.2; TraesCS1D02G350600.2; TraesCS1D02G350600.
DR   Gramene; TraesCS1D03G0823200.2; TraesCS1D03G0823200.2.CDS; TraesCS1D03G0823200.
DR   Gramene; TraesRN1D0100871100.2; TraesRN1D0100871100.2; TraesRN1D0100871100.
DR   Proteomes; UP000019116; Chromosome 1D.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0050664; F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor; IEA:InterPro.
DR   GO; GO:0004601; F:peroxidase activity; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   Gene3D; 1.10.238.10; EF-hand; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR013130; Fe3_Rdtase_TM_dom.
DR   InterPro; IPR013623; NADPH_Ox.
DR   PANTHER; PTHR11972; NADPH OXIDASE; 1.
DR   PANTHER; PTHR11972:SF202; OS05G0528000 PROTEIN; 1.
DR   Pfam; PF01794; Ferric_reduct; 1.
DR   Pfam; PF08414; NADPH_Ox; 1.
DR   SUPFAM; SSF47473; EF-hand; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        407..426
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        546..566
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        586..611
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          283..318
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   REGION          1..114
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          151..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..37
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        76..91
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   647 AA;  72528 MW;  D870B31BB8B4A63B CRC64;
     MRGVAGGGGA PGRPRWGGGS GATTPRSLST GSSPRGSDRS SDDGEELVEV TLDLQEDDTI
     VLRSVEPAAA ANANAAASAA ASSSGASPSV MGWSAEPTPP PGAGPSRSRS PAIRRTSSHR
     LLQFSQELKA GVSRAKQISQ DLTKRFTRTQ SRAALAEPPQ PPPAAHPPSG IESALAARAE
     RRQRAQLDRT KSTAQRAIKG LRFISGNTKA SNNAWIEVQR NFDRLALDGR LSRADFPQCI
     GMMESKEFAM ELFDTLCRRR QMQSDHINRE ELREIWSQIT DNSFDSRLQI FFDMVDKDAD
     GHITEAEVKE IIMLSASANK LARLKEQAEE YAALIMEELD PEGLGYIELW QLETLLLQKD
     TYVNYSQALS YTSQALSQNL AGLRHKSPIR KMSSKLSYYL EDNWKRLWVL ALWIGIMAGL
     FIWKFIQYRN RYVFSVMGYC VTIAKGAAET LKLNMALILL PVCRNTITWL RNTRAARALP
     FDDNINFHKT IAAAIVVGVI LHAGNHLACD FPRLIDSSDE TYAPLRQYFG ETKPTYLALV
     RGVEGVTGVI MVVCMLIAFT LATRWFRRSL VKLPKPFDKL TGFNAFWYSH HLFIIVYISL
     VIHGERLYLI LDWYKRTTWM YLAVPVGLYV GERTLRFFRW PYILVMF
//