ID A0A3B6A187_WHEAT Unreviewed; 525 AA.
AC A0A3B6A187;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=3-ketoacyl-CoA synthase {ECO:0000256|PIRNR:PIRNR036417};
DE EC=2.3.1.- {ECO:0000256|PIRNR:PIRNR036417};
GN ORFNames=CFC21_013878 {ECO:0000313|EMBL:KAF6997674.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS1D02G414600.1.cds1};
RN [1] {ECO:0000313|EMBL:KAF6997674.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF6997674.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS1D02G414600.1.cds1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS1D02G414600.1.cds1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS1D02G414600.1.cds1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF6997674.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF6997674.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC {ECO:0000256|PIRNR:PIRNR036417}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000256|ARBA:ARBA00005531,
CC ECO:0000256|PIRNR:PIRNR036417}.
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DR EMBL; CM022213; KAF6997674.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6A187; -.
DR SMR; A0A3B6A187; -.
DR STRING; 4565.A0A3B6A187; -.
DR EnsemblPlants; TraesCS1D02G414600.1; TraesCS1D02G414600.1.cds1; TraesCS1D02G414600.
DR Gramene; TraesCAD_scaffold_081774_01G000100.1; TraesCAD_scaffold_081774_01G000100.1; TraesCAD_scaffold_081774_01G000100.
DR Gramene; TraesCLE_scaffold_071231_01G000400.1; TraesCLE_scaffold_071231_01G000400.1; TraesCLE_scaffold_071231_01G000400.
DR Gramene; TraesCS1D02G414600.1; TraesCS1D02G414600.1.cds1; TraesCS1D02G414600.
DR Gramene; TraesCS1D03G0959800.1; TraesCS1D03G0959800.1.CDS1; TraesCS1D03G0959800.
DR Gramene; TraesKAR1D01G0344160.1; cds.TraesKAR1D01G0344160.1; TraesKAR1D01G0344160.
DR Gramene; TraesPAR_scaffold_077573_01G000100.1; TraesPAR_scaffold_077573_01G000100.1; TraesPAR_scaffold_077573_01G000100.
DR Gramene; TraesROB_scaffold_075275_01G000100.1; TraesROB_scaffold_075275_01G000100.1; TraesROB_scaffold_075275_01G000100.
DR OMA; HHSKLCG; -.
DR OrthoDB; 930987at2759; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000019116; Chromosome 1D.
DR Proteomes; UP000815260; Chromosome 1D.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00831; CHS_like; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR012392; 3-ktacl-CoA_syn.
DR InterPro; IPR013747; ACP_syn_III_C.
DR InterPro; IPR013601; FAE1_typ3_polyketide_synth.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR31561; 3-KETOACYL-COA SYNTHASE; 1.
DR PANTHER; PTHR31561:SF23; 3-KETOACYL-COA SYNTHASE; 1.
DR Pfam; PF08541; ACP_syn_III_C; 1.
DR Pfam; PF08392; FAE1_CUT1_RppA; 1.
DR PIRSF; PIRSF036417; 3-ktacl-CoA_syn; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|PIRNR:PIRNR036417};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Transferase {ECO:0000256|PIRNR:PIRNR036417};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 44..65
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 86..105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 103..391
FT /note="FAE"
FT /evidence="ECO:0000259|Pfam:PF08392"
FT DOMAIN 408..487
FT /note="Beta-ketoacyl-[acyl-carrier-protein] synthase III C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF08541"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 246
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
FT ACT_SITE 325
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
FT ACT_SITE 409
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
FT ACT_SITE 413
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
FT ACT_SITE 442
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
FT ACT_SITE 446
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
SQ SEQUENCE 525 AA; 58210 MW; 379CC2345EB2E21D CRC64;
MNGGIAPPPA AAATEAETAA TTPSHRRLPD FLQSVNLKYV KLGYHYLITH LITLLLLPLM
AVIVLEAGRT DPDDLRQLWL HLQYNLVSVL VLSAVLVFGA TVYVLTRPRP VYLVDFACYK
APDHLKVGFQ EFLRHSALCG FSNDALEFQR KILERSGLSE ETYCPEGMHA IPPEPTMANA
RAEAESVMFG ALDSLFAATG VKPKDVGILV VNCSLFNPTP SLSAMIVNRY KLRGNVRSFN
LGGMGCSAGV IAIDLARDML QVHRGTYAVV VSTENITQNW YFGNRKSMLI PNCLFRVGCS
AVLLSNRGAD RRRAKYSLKH VVRTHKGADD KAFNCVYQEQ DGEGKTGVSL SKDLMAIAGG
ALKTNITTLG PLVLPFSEQL LFFATLVSKK LFNAKVKPYI PDFKLAFEHF CIHAGGRAVI
DELEKNLQLQ PVHVEASRMT LHRFGNTSSS SIWYELAYME AKGRVRRGDR IWQIAFGSGF
KCNSAVWHAL RNVKPSPSTP WDDCIDRYPV ELVDGFPTHN HKQQQ
//
