ID A0A3B6A234_WHEAT Unreviewed; 871 AA.
AC A0A3B6A234;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=CFC21_014003 {ECO:0000313|EMBL:KAF6997830.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS1D02G427500.1};
RN [1] {ECO:0000313|EMBL:KAF6997830.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF6997830.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS1D02G427500.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS1D02G427500.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS1D02G427500.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF6997830.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF6997830.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC DDX11/CHL1 sub-subfamily. {ECO:0000256|ARBA:ARBA00008435}.
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DR EMBL; CM022213; KAF6997830.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6A234; -.
DR STRING; 4565.A0A3B6A234; -.
DR EnsemblPlants; TraesCS1D02G427500.1; TraesCS1D02G427500.1; TraesCS1D02G427500.
DR Gramene; TraesCAD_scaffold_026862_01G000100.1; TraesCAD_scaffold_026862_01G000100.1; TraesCAD_scaffold_026862_01G000100.
DR Gramene; TraesCLE_scaffold_021123_01G000100.1; TraesCLE_scaffold_021123_01G000100.1; TraesCLE_scaffold_021123_01G000100.
DR Gramene; TraesCS1D02G427500.1; TraesCS1D02G427500.1; TraesCS1D02G427500.
DR Gramene; TraesCS1D03G0983600.1; TraesCS1D03G0983600.1.CDS; TraesCS1D03G0983600.
DR Gramene; TraesKAR1D01G0348640.1; cds.TraesKAR1D01G0348640.1; TraesKAR1D01G0348640.
DR Gramene; TraesPAR_scaffold_056385_01G000100.1; TraesPAR_scaffold_056385_01G000100.1; TraesPAR_scaffold_056385_01G000100.
DR Gramene; TraesROB_scaffold_070772_01G000100.1; TraesROB_scaffold_070772_01G000100.1; TraesROB_scaffold_070772_01G000100.
DR Gramene; TraesWEE_scaffold_053454_01G000100.1; TraesWEE_scaffold_053454_01G000100.1; TraesWEE_scaffold_053454_01G000100.
DR OMA; HAINQSI; -.
DR OrthoDB; 124793at2759; -.
DR Proteomes; UP000019116; Chromosome 1D.
DR Proteomes; UP000815260; Chromosome 1D.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IBA:GO_Central.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0006974; P:DNA damage response; IEA:UniProt.
DR GO; GO:0032508; P:DNA duplex unwinding; IBA:GO_Central.
DR GO; GO:0034085; P:establishment of sister chromatid cohesion; IBA:GO_Central.
DR GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR CDD; cd18788; SF2_C_XPD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010614; RAD3-like_helicase_DEAD.
DR InterPro; IPR013020; Rad3/Chl1-like.
DR NCBIfam; TIGR00604; rad3; 1.
DR PANTHER; PTHR11472:SF41; ATP-DEPENDENT DNA HELICASE DDX11-RELATED; 1.
DR PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116}.
FT DOMAIN 8..406
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51193"
FT REGION 70..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..146
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 871 AA; 96243 MW; F4402DF63C042B94 CRC64;
MPPPPPPRQD FPAFPFAPYP IQSEFMSFLY SALSSGPRAL ALLESPTGTG KTLSIICSAL
QWLLDHRDAA PERANGSGPA AAGGEDDDEP DWMRDFTPLP PKKGVRKKSE THPRRRQGTR
KVGGSEKSEG TGENDGEEEF LLDEYESDGE EGTRPHAAGK RPHCGGGGGS SSSESEDEEE
EEEATPKVYF TSRTHSQLSQ FVRELKRTDF SGKLRTVCLG SRKSLCINMD VQKLGSANRI
NERCLELQKN KKSSKIKVEG DNKKGHRTKT SCGCPMLRNR SLQKQFRSEV SDHGALDIED
LAQIGRKVGT CPYYGARDMV RSADLVVLPY QSLLLKSARE SLGLNLKNSV VIIDEAHNLA
DSLTSMYNSK VTSSQLRAVL SHLEAYLNRF QNVLGAGNRR YIQTLTVLTR SFLRCLISNE
DCSSAVTSLT INKFLFSLDI DNINIVKLCQ YLKESNIIHK VSGYANKLFF TENGAGDLNH
GQQHGEGSSI TSFQALADFL RSLLYCNDDG RIIVARHKPG GHSEDAYIKF VMLCAEKTFS
EVTDDAHAVI MAGGTLQPIE ETRLRLFPGL LPSDIKFFSC NHIVPPESIL PIAVTCGPSG
KKFDFSHSSR SSPTMIEELG RFLCNIVTIV PEGIVMFFSS YDYEKQVYDA WMASGTISKI
SKKKHVFREP RSSVDVEMIL NKYKEAIQSC CSKGSGDTSV NGALLMAVVG GKISEGINFS
DGMGRCVVMV GLPYPSPDDM ELMETIKHIG NYSSTSSVAG DDESLSRDDE CKVEPGFGIL
RKSGKSGQEY YENLCMKAVN QCIGRAIRHV NDYAAMLLVD SRYSHTSSGR GFSCPVEKLP
QWIKTRLTCG QNYGEVHRLL LQFFKINKQI H
//
