ID A0A3B6AQA3_WHEAT Unreviewed; 1316 AA.
AC A0A3B6AQA3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Disease resistance N-terminal domain-containing protein {ECO:0000259|Pfam:PF18052};
GN ORFNames=CFC21_014958 {ECO:0000313|EMBL:KAF6998870.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS2A02G059200.1.cds1};
RN [1] {ECO:0000313|EMBL:KAF6998870.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF6998870.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS2A02G059200.1.cds1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS2A02G059200.1.cds1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS2A02G059200.1.cds1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF6998870.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF6998870.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR EMBL; CM022214; KAF6998870.1; -; Genomic_DNA.
DR STRING; 4565.A0A3B6AQA3; -.
DR EnsemblPlants; TraesCS2A02G059200.1; TraesCS2A02G059200.1.cds1; TraesCS2A02G059200.
DR Gramene; TraesCAD_scaffold_053379_01G000100.1; TraesCAD_scaffold_053379_01G000100.1; TraesCAD_scaffold_053379_01G000100.
DR Gramene; TraesCLE_scaffold_156196_01G000100.1; TraesCLE_scaffold_156196_01G000100.1; TraesCLE_scaffold_156196_01G000100.
DR Gramene; TraesCS2A02G059200.1; TraesCS2A02G059200.1.cds1; TraesCS2A02G059200.
DR Gramene; TraesKAR2A01G0024760.1; cds.TraesKAR2A01G0024760.1; TraesKAR2A01G0024760.
DR Gramene; TraesPAR_scaffold_057624_01G000100.1; TraesPAR_scaffold_057624_01G000100.1; TraesPAR_scaffold_057624_01G000100.
DR Gramene; TraesROB_scaffold_020780_01G000100.1; TraesROB_scaffold_020780_01G000100.1; TraesROB_scaffold_020780_01G000100.
DR Gramene; TraesWEE_scaffold_033793_01G000100.1; TraesWEE_scaffold_033793_01G000100.1; TraesWEE_scaffold_033793_01G000100.
DR OMA; WRYLWWA; -.
DR Proteomes; UP000019116; Chromosome 2A.
DR Proteomes; UP000815260; Chromosome 2A.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1062; OS11G0647000 PROTEIN; 1.
DR Pfam; PF18052; Rx_N; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116}.
FT DOMAIN 7..87
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT REGION 286..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1290..1316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 561..588
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 286..310
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1316 AA; 147952 MW; 6A0EB4D6A00C5C95 CRC64;
MAELASGAVS SLLGLLRNEA LLLSRVGSDS EFIKEEMESM HSFLEHLART APPAGGGGHD
EQVHTWMKQV RDLAHDCSNC IDLYLRRGDP AVYRARAGRW RYLWWASWLV QRMVAQHNVA
IRLRELKERA RDVGNRRLWY GVEIPRKEEA APLPSSSSQA AGIEYKEDED YQIQAANGSD
PRQRALEPRL VEEYCAEKLV EKLANWQELQ AKTNNRISMA SIAIVAPDDT KGAGTVAQDS
LRFATKNFKR TVWVNLSALH FPWDLPLLPS EILSYILYEC EQQKQHEDEQ QKQHEDEQQK
QHEDEQQKVT GGQGEVKPKM PIPWEGYSYK ARLRYEILNM FNYGEIRKQI DEIRNKVREV
DKGEIGGVDR GKVEENKCLG IFHHALRLVL NTLVRPLSSE GAIEETASLL KDHMETGESN
SKTQIHLDNS QYEDILRKVF PTNKPLQSQQ IQEATTSSAT TLSEAHIKEI IHNHKITLDI
ILGLLPKPQL LEGTSTKEQA IDAAASVSKE ISGEATGAAA AVIKETKEKT KEVSEEVTSA
IASAVIEETK EKTETSGEVS RDIAAAVVNQ TKEKLKELSA EVTSAIAAAV IKETKEKMKE
MDITGAIAAA VIEEAKEKMK GIVSGEVEAT SDVAAAITET IKETLEKMSQ IPWRIWGLLY
TKGIVDKIKP RLKNKKTLII LQDDKDYVSA ESRWEESRNA LNLLGCAPGS TVIVSTKNSE
KAKDFCYPPG EPITCSLVGL YHDTVLQLTK PRMINGNDGD IPGILREILA KCHPHEFCMK
IFVYALYTNP NRSYEELCKL NEDLAPAKTL GSKAKNMIKF SYKDLPREHK TCLLYLAIFP
QGHNIKRSTL IGRWVTEGLI TKQDWATAVH HAEQCFDTLI KKGLILPHDI GAAGKVKSCM
VGDQVHGFIT EVAEKEHILD ARLSDLWARH FSIFSGLRLR ASDGIEKFVY KLPKYSPQLP
LLKVLDLEGT QCFDKNHYLR DICNKMLLLK YLSLRGTNVR HLPSEINNLH ELEVLDIRET
MVPERATRNI LLLKLRRFLA SRVDPNSRLN DKSARFPVQI PFKIEKMENL EILSNVRASG
DGSELKEIRH LWQLRKLNVV IEDRNNHLEK LLRAIGDLKD CLQSLSITIS YNTRTKSTLS
NKEMRDLLRQ SPKHLESLSI NGVTQSGQLL ELLAKGSDEL AKVTLTGTLL EEGDLVVLAV
LPKLHSVRLR SNAYNGRELT FKKDVFPQLK YFLVEGSNKA VTDIKFEDGA ATELEKIVLS
STNIRFLSGI ENLPKLKELE LEGNQSLLSF SQDKVSPDQS TESGSAEQNT KGEATL
//
