ID A0A3B6AZ49_WHEAT Unreviewed; 458 AA.
AC A0A3B6AZ49;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=E2F/DP family winged-helix DNA-binding domain-containing protein {ECO:0000259|SMART:SM01372};
GN ORFNames=CFC21_017337 {ECO:0000313|EMBL:KAF7001728.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS2A02G297400.1};
RN [1] {ECO:0000313|EMBL:KAF7001728.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7001728.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS2A02G297400.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS2A02G297400.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS2A02G297400.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7001728.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7001728.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU003796}.
CC -!- SIMILARITY: Belongs to the E2F/DP family.
CC {ECO:0000256|ARBA:ARBA00010940, ECO:0000256|RuleBase:RU003796}.
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DR EMBL; CM022214; KAF7001728.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6AZ49; -.
DR SMR; A0A3B6AZ49; -.
DR STRING; 4565.A0A3B6AZ49; -.
DR PaxDb; 4565-Traes_2AL_8EC530273-1; -.
DR EnsemblPlants; TraesCS2A02G297400.1; TraesCS2A02G297400.1; TraesCS2A02G297400.
DR Gramene; TraesCAD_scaffold_067166_01G000300.1; TraesCAD_scaffold_067166_01G000300.1; TraesCAD_scaffold_067166_01G000300.
DR Gramene; TraesCLE_scaffold_072432_01G000100.1; TraesCLE_scaffold_072432_01G000100.1; TraesCLE_scaffold_072432_01G000100.
DR Gramene; TraesCS2A02G297400.1; TraesCS2A02G297400.1; TraesCS2A02G297400.
DR Gramene; TraesCS2A03G0740600.1; TraesCS2A03G0740600.1.CDS; TraesCS2A03G0740600.
DR Gramene; TraesKAR2A01G0322070.1; cds.TraesKAR2A01G0322070.1; TraesKAR2A01G0322070.
DR Gramene; TraesPAR_scaffold_064616_01G000300.1; TraesPAR_scaffold_064616_01G000300.1; TraesPAR_scaffold_064616_01G000300.
DR Gramene; TraesROB_scaffold_089333_01G000100.1; TraesROB_scaffold_089333_01G000100.1; TraesROB_scaffold_089333_01G000100.
DR Gramene; TraesWEE_scaffold_003211_01G000700.1; TraesWEE_scaffold_003211_01G000700.1; TraesWEE_scaffold_003211_01G000700.
DR OMA; MWTTACI; -.
DR OrthoDB; 1761at2759; -.
DR Proteomes; UP000019116; Chromosome 2A.
DR Proteomes; UP000815260; Chromosome 2A.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd14660; E2F_DD; 1.
DR Gene3D; 6.10.250.540; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR015633; E2F.
DR InterPro; IPR037241; E2F-DP_heterodim.
DR InterPro; IPR032198; E2F_CC-MB.
DR InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12081:SF81; E2F_DP FAMILY WINGED-HELIX DNA-BINDING DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12081; TRANSCRIPTION FACTOR E2F; 1.
DR Pfam; PF16421; E2F_CC-MB; 1.
DR Pfam; PF02319; E2F_TDP; 1.
DR SMART; SM01372; E2F_TDP; 1.
DR SUPFAM; SSF144074; E2F-DP heterodimerization region; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003796};
KW Nucleus {ECO:0000256|RuleBase:RU003796};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU003796};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU003796}.
FT DOMAIN 145..210
FT /note="E2F/DP family winged-helix DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01372"
FT REGION 33..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 112..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 435..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 215..256
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 123..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 458 AA; 49960 MW; E29A6E3F3BF96BFB CRC64;
MSGGGRPQAA QQIVQSVQKC VPLAPERPPF AVPAEYHRFP LPPSSSAPAA ASRGSAGGDV
EEGIVIRMPL KRKAPCGESD AIESTEWMIT SPGFTEGVSS PHMTPVSGKA ARTYKSKAKG
SKDGLQTPIS NAGSPGTPLT PGSSRAEHSL GELTKKFISL LKQAEDGILD LNHVAEILVV
KKRRIYDITN VLEGIGLLEK KLKNRIRWRG LDDSGANLDN EISVLETELE NLKLQEKALD
NRISEMHEKV RELTEEENNQ RWLYLTEDDI KGLPCFQNET LIAIKAPHGT TLEVPDPDEA
GDYVQRRYTI VIRSTMGSID LYLVSKFEEN MEELVGVTTP PRHANVAEPA STDGFIATEA
GQSSRSKDKL PNIQHIHKTP DLNAQNFGGM AKITPEFDVD ADYYLLTDGD ASSITDMWRT
APEVQWDQFL AEEATAPRTP QQQPAVVSKS TAVGPTCG
//
