ID A0A3B6BZJ4_WHEAT Unreviewed; 1205 AA.
AC A0A3B6BZJ4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=NB-ARC domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CFC21_020702 {ECO:0000313|EMBL:KAF7005588.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS2B02G022100.1};
RN [1] {ECO:0000313|EMBL:KAF7005588.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7005588.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS2B02G022100.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS2B02G022100.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS2B02G022100.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7005588.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7005588.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR EMBL; CM022215; KAF7005588.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6BZJ4; -.
DR STRING; 4565.A0A3B6BZJ4; -.
DR EnsemblPlants; TraesCS2B02G022100.1; TraesCS2B02G022100.1; TraesCS2B02G022100.
DR Gramene; TraesCS2B02G022100.1; TraesCS2B02G022100.1; TraesCS2B02G022100.
DR Gramene; TraesCS2B03G0003600.1; TraesCS2B03G0003600.1.CDS; TraesCS2B03G0003600.
DR Gramene; TraesKAR2B01G0000560.1; cds.TraesKAR2B01G0000560.1; TraesKAR2B01G0000560.
DR Gramene; TraesWEE_scaffold_028265_01G000100.1; TraesWEE_scaffold_028265_01G000100.1; TraesWEE_scaffold_028265_01G000100.
DR OMA; ESQYDGD; -.
DR Proteomes; UP000019116; Chromosome 2B.
DR Proteomes; UP000815260; Chromosome 2B.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1135; OS08G0246300 PROTEIN; 1.
DR Pfam; PF00931; NB-ARC; 2.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF52047; RNI-like; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116}.
FT DOMAIN 12..92
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 196..362
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT DOMAIN 406..649
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT COILED 119..146
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1205 AA; 136475 MW; 87F57CBFDAA1E886 CRC64;
MTDLVVGMAK SVVDGALSKA QAAMEEDKKL RQSAQRNLVF ITGEFQMMQS FLNIADSERL
KNPVVRTWVL QIRELAYDVE DCIEFVVHLD KKNGWWLRLL KPANRLIRPC VDLSGAVLLD
AAVDELEQLK ARVEDVSSRN ARYRLINSDS GSKPPTATEE PASRVTVGVT AVNRLIEAAN
TNQEGLNITH LLPKEGHNLR VISIWGTGGG DVGMASIAWN AFTDEDTCQN FVCRAWVKLM
HPIEPQEFVR SLTAQFHANS CTEDQASSSG GVIRKTQATQ DPLKDFERLL TENRYLIVLE
DLSTVAEWAS IQRFFPKKKN GSCIILSTQQ FEVASLSVGR PYQVLHLNQL SAAEHSAYAF
FTEGSQCDGE KGIASKNTVN NCKRAAAKTW IDNHPLVGRE LEMKELHNNV IRTRARAYQV
MSVWGFTGVG KSALVKSMFC DKIQVVKNNL FQKYGWVDVS HPFSLWDFSR TLLSNFGSEK
LQDTEHTYLY SMGSTNPVTQ CREILKKQKC MVVIDGLQST KEWDLIKTQL LPESNRWNVI
IVVTTEKEIA SHCHGDKGHV LFNVKGLDDD TAVELFEKES KKYKVAEDKV AEIRELTSIC
GGLPKVIVEI ARSFAKNTDR WKLALSENNK FMLELEKNGE FLSLRSLLDW MNSSFRKYSD
SIKSCILYLP VFPRNHFIRR RRLVRRWIAE GYSRDNHDES AETIGEKQFN DLIDLRIIQQ
PSMLGLGDTR MVVCQVNGFF REYIVSHQME ENLVFELRGS CALTTQRTGR HLVISKSWVR
DGIVFENIDF SRLRSLTVFG TWKSFFISEG MKLLRVLDLE DASEVEYNDL KKMVKFMCRL
KFLSLRGRRE IKRLPRSIGG LKQLESLDVR NTSIVTLPKS IIKLEKLQYI RAGTKAPSKK
TATPHRLGYQ LFNYSSGCHA VGIVVPPGIG KLTALHTLGV VNVRASGTKA VLEGLKKLTH
LHKLGVSGIN KSNSDKFFLA ISVFVRLESL SVQLEENSQG CLNDIKLPLK GLQSLKLYGL
GDRLPEWKAQ LTMLTKLDLE IAKLTEDRVS VQLEGVQSEG VQSEGVAQQR PREHTSGVIK
FLSELPRLCI LRLRVNHLQD NQLDVSIIYN DLEVESFEKL KIFEIACSFS KVTFGEKTMK
KLEQLKVECY SWSTFLGLEH LDELKEVLLK GPRDEELMSE INTKLENHPK VKKPVVKLEE
QTSSS
//
