ID A0A3B6C840_WHEAT Unreviewed; 344 AA.
AC A0A3B6C840;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Aldose 1-epimerase {ECO:0000256|PIRNR:PIRNR005096};
DE EC=5.1.3.3 {ECO:0000256|PIRNR:PIRNR005096};
GN ORFNames=CFC21_024009 {ECO:0000313|EMBL:KAF7009477.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS2B02G341400.1};
RN [1] {ECO:0000313|EMBL:KAF7009477.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7009477.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS2B02G341400.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS2B02G341400.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS2B02G341400.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7009477.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7009477.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose = beta-D-glucose; Xref=Rhea:RHEA:10264,
CC ChEBI:CHEBI:15903, ChEBI:CHEBI:17925; EC=5.1.3.3;
CC Evidence={ECO:0000256|PIRNR:PIRNR005096};
CC -!- PATHWAY: Carbohydrate metabolism; hexose metabolism.
CC {ECO:0000256|ARBA:ARBA00005028, ECO:0000256|PIRNR:PIRNR005096}.
CC -!- SIMILARITY: Belongs to the aldose epimerase family.
CC {ECO:0000256|ARBA:ARBA00006206, ECO:0000256|PIRNR:PIRNR005096}.
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DR EMBL; CM022215; KAF7009477.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6C840; -.
DR PaxDb; 4565-Traes_2DL_0032C6179-1; -.
DR EnsemblPlants; TraesCS2B02G341400.1; TraesCS2B02G341400.1; TraesCS2B02G341400.
DR Gramene; TraesCAD_scaffold_003269_01G000400.1; TraesCAD_scaffold_003269_01G000400.1; TraesCAD_scaffold_003269_01G000400.
DR Gramene; TraesCLE_scaffold_017636_01G000400.1; TraesCLE_scaffold_017636_01G000400.1; TraesCLE_scaffold_017636_01G000400.
DR Gramene; TraesCS2B02G341400.1; TraesCS2B02G341400.1; TraesCS2B02G341400.
DR Gramene; TraesCS2B03G0888200.2; TraesCS2B03G0888200.2.CDS; TraesCS2B03G0888200.
DR Gramene; TraesPAR_scaffold_003420_01G000400.1; TraesPAR_scaffold_003420_01G000400.1; TraesPAR_scaffold_003420_01G000400.
DR Gramene; TraesRN2B0100915700.2; TraesRN2B0100915700.2; TraesRN2B0100915700.
DR Gramene; TraesROB_scaffold_021260_01G000200.1; TraesROB_scaffold_021260_01G000200.1; TraesROB_scaffold_021260_01G000200.
DR Gramene; TraesWEE_scaffold_008510_01G000400.1; TraesWEE_scaffold_008510_01G000400.1; TraesWEE_scaffold_008510_01G000400.
DR UniPathway; UPA00242; -.
DR Proteomes; UP000019116; Chromosome 2B.
DR Proteomes; UP000815260; Chromosome 2B.
DR GO; GO:0004034; F:aldose 1-epimerase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0019318; P:hexose metabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd09019; galactose_mutarotase_like; 1.
DR Gene3D; 2.70.98.10; -; 1.
DR InterPro; IPR015443; Aldose_1-epimerase.
DR InterPro; IPR008183; Aldose_1/G6P_1-epimerase.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR047215; Galactose_mutarotase-like.
DR InterPro; IPR014718; GH-type_carb-bd.
DR PANTHER; PTHR10091:SF48; ALDOSE 1-EPIMERASE; 1.
DR PANTHER; PTHR10091; ALDOSE-1-EPIMERASE; 1.
DR Pfam; PF01263; Aldose_epim; 1.
DR PIRSF; PIRSF005096; GALM; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|PIRNR:PIRNR005096};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|PIRNR:PIRNR005096};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..344
FT /note="Aldose 1-epimerase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040069828"
FT ACT_SITE 177
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
FT ACT_SITE 310
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
FT BINDING 177..179
FT /ligand="beta-D-galactose"
FT /ligand_id="ChEBI:CHEBI:27667"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-3"
FT BINDING 248
FT /ligand="beta-D-galactose"
FT /ligand_id="ChEBI:CHEBI:27667"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-2"
SQ SEQUENCE 344 AA; 37756 MW; 1C19E0E1B1384D7A CRC64;
MARAPVFPAL LCLAVLALAG GADARKMVGV YELKRGDFSV KMTNWGATIM SVLVPDSKGN
LADVVLGMDT LAEYVRMARG RFVLDGKVYH TYINDGKNAI HGGKRGFSKV IWTVKEYVAG
GDSPYITMYY RSFDGEQGFP GDLDVYATYQ LTGPYELSIR TNATALNKAT PVNFLQHVYL
NLGGQGSGDI LGHTLQLSAS RYTPLDVEML PSSGRVDPVA GTSYDFRTPM PIGARIRQVM
GGKVYGYDIN YVIDGEGMRK VAVARDGKSG RALELWANQP AMQLYTGNFL NHTKGKGGKL
YEQYGGFCLE TQAYPDAVNH PEFPSVTVRP GQVYKHDMRF TFSF
//
