ID A0A3B6CGH2_WHEAT Unreviewed; 1048 AA.
AC A0A3B6CGH2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Disease resistance N-terminal domain-containing protein {ECO:0000259|Pfam:PF18052};
GN ORFNames=CFC21_026490 {ECO:0000313|EMBL:KAF7012282.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS2B02G588500.1.cds1};
RN [1] {ECO:0000313|EMBL:KAF7012282.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7012282.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS2B02G588500.1.cds1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS2B02G588500.1.cds1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS2B02G588500.1.cds1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7012282.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7012282.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR EMBL; CM022215; KAF7012282.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6CGH2; -.
DR STRING; 4565.A0A3B6CGH2; -.
DR EnsemblPlants; TraesCS2B02G588500.1; TraesCS2B02G588500.1.cds1; TraesCS2B02G588500.
DR Gramene; TraesCS2B02G588500.1; TraesCS2B02G588500.1.cds1; TraesCS2B02G588500.
DR Gramene; TraesCS2B03G1474600.1; TraesCS2B03G1474600.1.CDS1; TraesCS2B03G1474600.
DR Gramene; TraesROB_scaffold_000201_01G000700.1; TraesROB_scaffold_000201_01G000700.1; TraesROB_scaffold_000201_01G000700.
DR OMA; AMEVHEG; -.
DR OrthoDB; 353413at2759; -.
DR Proteomes; UP000019116; Chromosome 2B.
DR Proteomes; UP000815260; Chromosome 2B.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1089; OS02G0301800 PROTEIN; 1.
DR Pfam; PF18052; Rx_N; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116}.
FT DOMAIN 12..93
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
SQ SEQUENCE 1048 AA; 119230 MW; FAC755B9C22C19DF CRC64;
MAELAIRSAH GAVDSLLRRL TRLIEDEAKL LSGVRGDVQY IKDEMDNVHG FLLNFVEDSC
TDNQMEVWVR HVRELARDSE NCVDVYEHKL STSAVARALA RYSGGSDILL WFNRALYRFG
MLMYTVPARH RLATEIRLLK ERAEHVSERR TRYGVRDPDP QKRAKQLEEV CGDDTNRKKD
PRIQHLLGDE DESLAGILEG DLKMLVSWLI GQGEEIQPDM LVAKRLTGPE DEMPWPKIPV
DESVSVAGTS WRERSKRRPG LATAVSKRWM LRSMSRRKII GLKEQLAQLE DNMPQQDFQL
GCITGSRDRM PRQDFQLGFI KGSRDKDSRP RVISIVQQRS GDDDLNYAQI VFEDSLIKDF
FGFRCRVRVG ENHAKWVFDD IIKDISSQQV DLKEWQETKY LIVLDDVRDE SLCHEIISGF
PPTTAGGHSV VLVITHSYAL ARSCSPNAVF PPLEPIVKFF FGKAVSLVEN NPENDTLKQV
IRSILSKCAP SLLCLKAFLH VLYVNPMRNI QELQGLCNDL TSDSPGNIRH ILMFWYNNLP
LHYKNCLIYL SIFPQNDGDH IKRTSLVRRW AAENLITGRN GSAAQDEAEH CFNVLVAKRF
LLCTGIGAAG KVKSCRVNSL ISKFISDIAR EEKFVDADLQ QDFSNRISIH NRSQLQQVLG
TLQASPRPSS CWNIRKHSTD TEDGQPLDDL TKFLETLPSF AQLGLVRVLD LEGFDGLKDH
HVDNICEIFQ LRYLNLRRTK ITKLPKKMEY LQQLETLDIR ETAVRSFATK VVVLPMLKHM
LAGYAQHSNE DMESFSTVCM PRGTGGMGNL QILCHVDVSG KEDRLVEIGR LQQLRKLGVV
FQSNRNNFKH LLQAIEKLNK SLLSLSLRVE TTQGHEITDI NAAEPTAFSP PKHLQSLNLC
GVRGGLPRWI KELHKLAKLT LCETHLEEGD ITSLGELIGL RCLRLRHRSY VQTKLTLQKG
AFKNLEFILI EGSDITDISF HKTPKIEKIV WKFREMKSIH GISRLPRLSR LELIGNCDPT
ATKEALFNHP NRPVVIHNGQ VIHSGGRR
//
