ID A0A3B6DC18_WHEAT Unreviewed; 1074 AA.
AC A0A3B6DC18;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN ORFNames=CFC21_029587 {ECO:0000313|EMBL:KAF7015862.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS2D02G249100.4};
RN [1] {ECO:0000313|EMBL:KAF7015862.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7015862.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS2D02G249100.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS2D02G249100.4};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS2D02G249100.4}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7015862.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7015862.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- SIMILARITY: Belongs to the peptidase C19 family.
CC {ECO:0000256|ARBA:ARBA00009085}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM022216; KAF7015862.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6DC18; -.
DR EnsemblPlants; TraesCS2D02G249100.4; TraesCS2D02G249100.4; TraesCS2D02G249100.
DR Gramene; TraesCS2D02G249100.4; TraesCS2D02G249100.4; TraesCS2D02G249100.
DR Gramene; TraesCS2D03G0571700.3; TraesCS2D03G0571700.3.CDS; TraesCS2D03G0571700.
DR Proteomes; UP000019116; Chromosome 2D.
DR Proteomes; UP000815260; Chromosome 2D.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00121; MATH; 1.
DR CDD; cd02659; peptidase_C19C; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR024729; USP7_ICP0-binding_dom.
DR InterPro; IPR029346; USP_C.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF644; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7; 1.
DR Pfam; PF00917; MATH; 1.
DR Pfam; PF00443; UCH; 1.
DR Pfam; PF14533; USP7_C2; 1.
DR Pfam; PF12436; USP7_ICP0_bdg; 1.
DR SMART; SM00061; MATH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 1.
DR PROSITE; PS50144; MATH; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 22..147
FT /note="MATH"
FT /evidence="ECO:0000259|PROSITE:PS50144"
FT DOMAIN 167..491
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT COILED 504..531
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1074 AA; 125989 MW; BE62E6B91418A806 CRC64;
MEVVPAEPAA TVENQPTEDT PISRFTWTID NLSRVNTKKL YSETFVVGGY KWRVLIFPRG
NNVEFLSMYL DVADSAVLPY GWTRYAQFSL SVVNQIHNKF TIRKETQHQF SARESDWGFT
SFMPLSELYN PSRGYLVNDT CVIEAEVAVC KVVDYWSYDS KKETGYVGLK NQGATCYMNS
LLQTLYHIPY FRKAVYHMPT TENDMPSGSI PLALQSLFYK LQYNDSSVST KELTKSFGWD
MHDSFMQHDV QELNRVLSEK LEDKMKGTVV EGTIQQLFEG HHMNYIECIN VDFKSTRKES
FYDLQLDVKG CQDVYASFDK YVEVERLEGD NKYHAEQHGL QDAKKGVLFI DFPPVLQLQL
KRFEYDFMRD TMVKINDRYE FPLQLDLDRD DGKYLSPDAD RNVRNLYTLH SVLVHSGGVH
GGHYYAFIRP TLSDQWFKFD DERVTKEDAK RALEEQYGGE EELPQTNPGL NNTPFKFTKY
SNAYMLVYIR ESDKDKIICN VDEKDIAEHL RIRLEKDREE KERRKKEKAE AHLYTIIKVA
RDDDLTAQIG KDIYFDLVDH DKVPSFRIQK QMPFTQFKEE VAKELGIPTQ FQRFWLWAKR
QNHTYRPNRP LTPQEEALTV GQLKEAANKA HNAELKLFLE VELGLDLKPL TLPDKTREDI
LLFFKLYDPE KEQLRYVGRL FVKASGRPQD ILPKLRKMAG FLQDDDVELY EEIKFEPNVM
CEYIDNRIIF RSCQLEDGDI VCFQKSPKPD TADQFRYPDV PSFLVYIRNR QVVHFRSLEK
PKEDDFCLEM SKIFTYDEVV EKVAQQLGVD DPSKIRLTSH NCYSQQPKPQ PIKYRGVERL
LDMLIHYNQT SDILYYEVLD IPLPELQALK TLKVSVHSIR LPKNSTVGDV LSDIKSKVDL
SHPDAELRLL EVFYHKIYKI FAPSEKIENI NDQYWTLRAE EVPEEEKNLG PFDRLIHVYH
FTKDTQNQTQ VQNFGEPFFM VIREDETLSS IKERLQKKLK VSDEDFSKWK FAYISLGRPD
YFEDSDTVAT RFQRNMYGAW EQYLGLEHPD TAPRKAHSAN QNRHSFERPV KIYN
//
