ID A0A3B6EEB2_WHEAT Unreviewed; 987 AA.
AC A0A3B6EEB2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=NB-ARC domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CFC21_033956 {ECO:0000313|EMBL:KAF7020913.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS3A02G073700.1};
RN [1] {ECO:0000313|EMBL:KAF7020913.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7020913.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS3A02G073700.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS3A02G073700.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS3A02G073700.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7020913.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7020913.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR EMBL; CM022217; KAF7020913.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6EEB2; -.
DR PaxDb; 4565-Traes_3B_67FB55469-1; -.
DR EnsemblPlants; TraesCS3A02G073700.1; TraesCS3A02G073700.1; TraesCS3A02G073700.
DR Gramene; TraesCS3A02G073700.1; TraesCS3A02G073700.1; TraesCS3A02G073700.
DR Gramene; TraesCS3A03G0162100.1; TraesCS3A03G0162100.1.CDS; TraesCS3A03G0162100.
DR Proteomes; UP000019116; Chromosome 3A.
DR Proteomes; UP000815260; Chromosome 3A.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1100; OS08G0332600 PROTEIN; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116}.
FT DOMAIN 10..88
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 171..383
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 987 AA; 112997 MW; 8D5076BC96B76418 CRC64;
MGTVLDALTS KFLTTLSQLI EDEIVMTLSV KKDIKRLKKN LEHFRAVRED AEALAMEDRQ
IEAWWKNMSD VMFDVDVIID LVMVQSQKFL LPARSLCFNQ PMVSCFEKLL FDHKVARRIK
DINEKLDEIK MNTEMFSLDR SIRQQFQVTT VDRNQTSPID ELEVVGREIK QSVDDIVQMI
VSGCHENSTS VLGIQGMGGI GKTTLAQKIY NDQMIREKFQ VHIWLCISQS YTETGLIKQA
IRMAGENCDQ LETELLPLLM DTIKGKSVFL VLDDVWKSDV WIDLLLSPFM RALNFHILVT
TRDLHVLSEM HATHIHQVNK MNYGDGLELL MKKSFQSSEQ ICEFKNIGYD IVKKCDGLPL
AIKVVAGVLS TKRTVAEWKS IRDSKWSIHG LPKELGGPLY LSYSNLPPQL KQCFLWCALL
PPNFAIGRDD VAYWWVAEGF VRKEHDYSIH EIAEEYYLEL IRRNLLQPIP MFVDKGESTM
HDLLRSLGQY LTKDHSLFMN AESNNSMSNL RRLGISHAIE EIPPLEEHKC LRSLLLFNNK
NFKSIRKDIF RKLEHIRVLV LRGTSIKDIP DSVGNLVLLR LLDLSYTEIN KLPESTGRLI
SLEYLSLLGC RQLDSLPAGL MRLSNISFLQ LDWTAIDHVP KGIAKFQQLY SLKGVFESGT
GFRLDELQRL PNIQRLWVQK LEKAAPVGEL VLKNSHNLRE LRLGCTMGST GERTRYQTGV
VERIQQVFDM LIPSPSLVYI YIDGFPGIRF PEWLCSEPEL NMPSLCHMHL NECISCSVLP
PAGQMPELLV LHIKGADEVV TIGTELLGKG VRSAAAFFPK LELLRLVSMG NLEKWSLNIR
NMCDDMEDNS QQLSLMPCLK RLLLFDCPKL RALPQDMYMI VNLKRIHIEG AHKLQEVVDL
PAVVWLKVMN NTCLRRISNL CKLQDLFAQD CPMLDHTENL CSLKRVYMID CLHAQVFRNC
LAEEEQGILV HVATDGHNIF PDESLYN
//
