ID A0A3B6EUS2_WHEAT Unreviewed; 359 AA.
AC A0A3B6EUS2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=E3 ubiquitin-protein ligase {ECO:0000313|EnsemblPlants:TraesCS3A02G505400.1};
GN ORFNames=CFC21_038359 {ECO:0000313|EMBL:KAF7026242.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS3A02G505400.1};
RN [1] {ECO:0000313|EMBL:KAF7026242.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7026242.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS3A02G505400.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS3A02G505400.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS3A02G505400.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7026242.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7026242.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination and
CC subsequent proteasomal degradation of target proteins. E3 ubiquitin
CC ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the
CC form of a thioester and then directly transfers the ubiquitin to
CC targeted substrates. It probably triggers the ubiquitin-mediated
CC degradation of different substrates. {ECO:0000256|ARBA:ARBA00024004}.
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DR EMBL; CM022217; KAF7026242.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6EUS2; -.
DR STRING; 4565.A0A3B6EUS2; -.
DR EnsemblPlants; TraesCS3A02G505400.1; TraesCS3A02G505400.1; TraesCS3A02G505400.
DR Gramene; TraesCAD_scaffold_092151_01G000100.1; TraesCAD_scaffold_092151_01G000100.1; TraesCAD_scaffold_092151_01G000100.
DR Gramene; TraesCLE_scaffold_039974_01G000100.1; TraesCLE_scaffold_039974_01G000100.1; TraesCLE_scaffold_039974_01G000100.
DR Gramene; TraesCS3A02G505400.1; TraesCS3A02G505400.1; TraesCS3A02G505400.
DR Gramene; TraesCS3A03G1187600.1; TraesCS3A03G1187600.1.CDS; TraesCS3A03G1187600.
DR Gramene; TraesPAR_scaffold_072626_01G000100.1; TraesPAR_scaffold_072626_01G000100.1; TraesPAR_scaffold_072626_01G000100.
DR Gramene; TraesRN3A0101216100.1; TraesRN3A0101216100.1; TraesRN3A0101216100.
DR OMA; ICIGREY; -.
DR OrthoDB; 383958at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000019116; Chromosome 3A.
DR Proteomes; UP000815260; Chromosome 3A.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR044286; SINL_plant.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR013010; Znf_SIAH.
DR PANTHER; PTHR46632; E3 UBIQUITIN-PROTEIN LIGASE SINA-LIKE 4; 1.
DR PANTHER; PTHR46632:SF29; RING-TYPE E3 UBIQUITIN TRANSFERASE; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 1.
DR PROSITE; PS51081; ZF_SIAH; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00455};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00455};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00455}.
FT DOMAIN 92..158
FT /note="SIAH-type"
FT /evidence="ECO:0000259|PROSITE:PS51081"
FT REGION 318..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..343
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 359 AA; 36949 MW; 3415231B6A154543 CRC64;
MGLGGGGGEG VLAVVPMEAI PMAEPQIVAG GKIVGLRADL LDCHNCRLPL KPPIFKCDAE
HLVCSSCRGL HGEACGGRAA VHSALADIFA AAATVPCGYE RYGCDAGGVV YHEAADHRRA
CQHAPCCCPD RAGAAGIGGC GFVGSRQDLL DHISGPDHSR PIIVVRYGQP WNLSLPLSRR
WHILVGEEDK AVAAAAGAER HRNLFLVSLG ERGATTAVSL VCVRVDGTAP SAPQFACKLA
VESDGCRLTL ESPLVCSSSL SGGLPAEVKC LPVPKDFLSG DSVPLSIHIE KLPAPPAPPL
GLGVAPACTS PVAATPPPCP AATIPPSRPS SGSSDNVAVK TVITDQSYKK RKSANPRKL
//
