ID A0A3B6FMQ1_WHEAT Unreviewed; 991 AA.
AC A0A3B6FMQ1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Helicase ATP-binding domain-containing protein {ECO:0000259|PROSITE:PS51193};
GN ORFNames=CFC21_041381 {ECO:0000313|EMBL:KAF7029695.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS3B02G242700.1};
RN [1] {ECO:0000313|EMBL:KAF7029695.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7029695.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS3B02G242700.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS3B02G242700.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS3B02G242700.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7029695.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7029695.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CM022218; KAF7029695.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6FMQ1; -.
DR SMR; A0A3B6FMQ1; -.
DR STRING; 4565.A0A3B6FMQ1; -.
DR EnsemblPlants; TraesCS3B02G242700.1; TraesCS3B02G242700.1; TraesCS3B02G242700.
DR Gramene; TraesCS3B02G242700.1; TraesCS3B02G242700.1; TraesCS3B02G242700.
DR Proteomes; UP000019116; Chromosome 3B.
DR Proteomes; UP000815260; Chromosome 3B.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IBA:GO_Central.
DR GO; GO:0070182; F:DNA polymerase binding; IBA:GO_Central.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IBA:GO_Central.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0045910; P:negative regulation of DNA recombination; IBA:GO_Central.
DR GO; GO:1904430; P:negative regulation of t-circle formation; IBA:GO_Central.
DR GO; GO:0010569; P:regulation of double-strand break repair via homologous recombination; IBA:GO_Central.
DR GO; GO:0090657; P:telomeric loop disassembly; IBA:GO_Central.
DR CDD; cd17970; DEAHc_FancJ; 1.
DR CDD; cd18788; SF2_C_XPD; 1.
DR Gene3D; 1.20.1160.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010614; RAD3-like_helicase_DEAD.
DR InterPro; IPR013020; Rad3/Chl1-like.
DR NCBIfam; TIGR00604; rad3; 1.
DR PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR PANTHER; PTHR11472:SF34; REGULATOR OF TELOMERE ELONGATION HELICASE 1; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116}.
FT DOMAIN 7..295
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51193"
FT REGION 70..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 801..821
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 860..886
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..92
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 862..886
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 991 AA; 110994 MW; E310E7F8F4EE4220 CRC64;
MPVYRIRGVD VDFPYDAYDC QITYMDRVLQ SLQQGNNALL ESPTGTGKTL CLLCSTLAWR
RTFGEFLRGG GGGGGGGGSQ PSGSQQSGAS ATQSSSYPVI IYASRTHSQL RQVIKELKAT
SYRPKMAVLG SREQMCIHEE VSKLQGKAQN NGCHYLCKKR LCRHNNIVTD YMKNNTEIGS
EPFDIEDLVN IGRTKGPCPY YISRELSKSV DILFAPYNYL IDPGNRRSLT GISWDNAVLI
FDEAHNLESI CADAASFDLL TSNLTSCITE AQECIQLCSF KRSIENSAEK QFDPENYAIL
KALLMALEKK IGELVIDSKE LGYTKPGSYI YEFLSELNIT SETSKKLIEI IDSASLLLEE
GNSGETKAGV KAKSTVSRLE TIRDMLDIIF KGGGQNHAKY YSFHVNESSR QTSGDSLQVF
GKASRTLSWW CFNPGLAMEE FLKLGVRSII LTSGTLSPLD SLAMELNLEF PVRLENPHVI
SQDQIWVGVV PVGPSGHPLN SSYRTRETVK YKQELGTVIV NFARIVPDGL LVFFPSYSMM
DKCIDYWKNR NHEHSVDDST IWQRMCKHKQ PVIEPRQSSN FPNAIEDYEA KLRDPSTFGA
IFFAVCRGKV SEGLDFADRA GRAVIVTGMP FSTPTDPKVR LKREYLDKQA KPSNKNPKTL
TGEEWYVQQA ARAVNQAVGR VIRHRHDYGA IIYCDERFVW PNYQSQMSYW LKPYIKCYSK
YGEVVQTLTR FFRDKVCVDP KEMDCNDSVT PPADKCLPQE ILSDSPATAV NEHRGTTASL
NATTRKNNYM KFTQITPANR TTLPMKHGCS TSSQLASSRG QFSQDSQVVD LTDNATMHGQ
LKEHTLKSMR LKKAKIADVS SQLKHNVESR ALTGNRGQQS TPPSKRSTIE QACEKNEAIQ
ERCGGQESTT GPAFLKLARE KLSTAEYGEF VEFMKALKLK TMHIKDSLEA IAKLFSSPGR
LTLLEGFRVF VSKNHLPLYE QLVRKYTMAN T
//
