ID A0A3B6FYN0_WHEAT Unreviewed; 726 AA.
AC A0A3B6FYN0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=DNA mismatch repair protein S5 domain-containing protein {ECO:0000259|SMART:SM01340};
GN ORFNames=CFC21_044588 {ECO:0000313|EMBL:KAF7033502.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS3B02G564100.3};
RN [1] {ECO:0000313|EMBL:KAF7033502.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7033502.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS3B02G564100.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS3B02G564100.3};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS3B02G564100.3}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7033502.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7033502.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; CM022218; KAF7033502.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6FYN0; -.
DR EnsemblPlants; TraesCS3B02G564100.3; TraesCS3B02G564100.3; TraesCS3B02G564100.
DR Gramene; TraesCS3B02G564100.3; TraesCS3B02G564100.3; TraesCS3B02G564100.
DR Gramene; TraesCS3B03G1409300.3; TraesCS3B03G1409300.3.CDS; TraesCS3B03G1409300.
DR Gramene; TraesKAR3B01G0539680.1; cds.TraesKAR3B01G0539680.1; TraesKAR3B01G0539680.
DR Gramene; TraesRN3B0101415500.3; TraesRN3B0101415500.3; TraesRN3B0101415500.
DR Proteomes; UP000019116; Chromosome 3B.
DR Proteomes; UP000815260; Chromosome 3B.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03483; MutL_Trans_MLH1; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR032189; Mlh1_C.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF16413; Mlh1_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116}.
FT DOMAIN 228..350
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 380..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 380..396
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 726 AA; 81140 MW; 35004B567859515D CRC64;
MEVDEPAPHG GGGGGAPPRI RRLEESVVNR IAAGEVVQRP SSAVKELVEN SIDAGASTVS
VTVKDGGLKL IQVSDDGHGI RCEDLPILCE RHTTSKLSAY EDLQTIKSMG FRGEALASMT
YVGHVTVTTI TEGQLHGYRV SYRDGVMEND PKPCAAVKGT QVMVENLFYN MVARRKTLQN
SNDDYPKIVD FISRFAVHHI NVNFSCRKHG ANRADVHSGS TSSRLDAIRN VYGASVVRDL
MEIQVSDENA VDEIFKMDGF ISNANYVAKK TTMILFINDR LVDCTSLKRA TEFVYSAILP
QASKPFIYMS INLPPEHVDV NIHPTKKEVS LLNQERIIEK IKDAIEEKLL NCNNTRIFQT
QALNSSALTQ SNIRKDMSTE ISTPTGEKSQ KVPVSQMVRT DPRDPSGRLH TYWQGQSSNL
EKKSDLVTVR NIVRSRRNPK DAGDLSSRHE LLTEIDSNLH PGLFDIVKNC TYVGVADEVF
ALIQHNTLLY LVNVVNVSKE LMYQQALCRF GNFNAIQLSE PAPLRELLTM ALKDDESMSD
VNEKEKLEIA EVNTEILKEN AEMINEYFSI HIDQGGNLTR LPVVLDQYTP DMDRLPEFML
TLGNDIAWDV EKECFRTAAA AIGNFYALHP PILPNPSGKG IRLYKRNKDS MGSAEPADND
LTDEDDVDQE LVAEAEAAWA QREWTIQHVL FPSMRLFLKP PKSMATDGTF VQIASLDKLY
KIFERC
//
