ID A0A3B6G378_WHEAT Unreviewed; 1179 AA.
AC A0A3B6G378;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=NB-ARC domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CFC21_045027 {ECO:0000313|EMBL:KAF7033965.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS3B02G604100.1};
RN [1] {ECO:0000313|EMBL:KAF7033965.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7033965.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS3B02G604100.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS3B02G604100.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS3B02G604100.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7033965.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7033965.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR EMBL; CM022218; KAF7033965.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6G378; -.
DR STRING; 4565.A0A3B6G378; -.
DR EnsemblPlants; TraesCS3B02G604100.1; TraesCS3B02G604100.1; TraesCS3B02G604100.
DR Gramene; TraesCS3B02G604100.1; TraesCS3B02G604100.1; TraesCS3B02G604100.
DR Gramene; TraesCS3B03G1525800.1; TraesCS3B03G1525800.1.CDS; TraesCS3B03G1525800.
DR OMA; SIMVEEM; -.
DR OrthoDB; 416388at2759; -.
DR Proteomes; UP000019116; Chromosome 3B.
DR Proteomes; UP000815260; Chromosome 3B.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1114; OS02G0475500 PROTEIN; 1.
DR Pfam; PF00931; NB-ARC; 2.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116}.
FT DOMAIN 16..105
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 183..343
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT DOMAIN 375..614
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 1179 AA; 131864 MW; 660E752E8D84AB68 CRC64;
MEGACLCLLK SACQCLAREA TSSAAKEMAL QAGVQEDAMI LAEELGEMHK FLADVDKYEE
ARGEMDPSGD AEEAPARRWV DKIRDMACDI QDCLLQLAPH RERPSLWRFR WTSLAPRHSI
AAELKDLVSQ VNRVSERRER YQVARFMAAL RKPPVSLVEE ARLATDIDHK FDLGQLLAWP
DESLLVISVW TMAGIGNGDT TSLIGLVYDD AKMFQCRAWV TATHPISLTE FLRGLARQLL
ANENNCMPPV SQSTLGFLGD TERMGTEELM MVVANHLDEK RYLVIIEDVC ARPTWDWIKI
LFPDHMNGSR IIVSSQRADV ARHCAGRLSR SFTLEGVSDN DAQLYVSSNQ AATTNEANVV
IKIEPYSELV GRKAEVADLT RRILEDGPDC YPISVYGASG IGKSVLVKKV IYDSLEMSTR
FEMLAWITMM RPFSQEEFLR SIISQFLACS PGGRQDSVSR TSNMSGDKLV TKILQLMEGG
RSLVVLDGLS ADEEWDQVKS CLWDDGNAKH SCTIVVTTTN AAVAHYCSGN KDTLCKLDPL
DSAAVRQLFY HKVFKRDGLI ELHKPMVDLA DHIIKKCDGD LCAITIISGL LGTKTRTSEA
WNSVLERYDS ELRNKPDRVA TAAAKLSYVD LPSHMKYLLQ YISIFLRGYS ITRRRLASAW
MAEIYSKNIR EDNAEELEKI FDGLVMRGIL HPLKRAETTG GRVNVCQVDD LFQQLGGSEV
KSGVSIHILD EHTVNRNSTI SQPRHLVVKS GWIRHDDEFK KIDHSCARSL TVFGEWSSFF
ISPSMKLLRV LDLEDTAGLV EHHDLEQIGD FRHLKYLSLR NTGISHLPNS LGKLQGLEVL
DIRGTYIAKL PSTIIHLTGL CHLRGGTMAT SMEGNSQLDF SCEVTSCCPQ PLQCAASSAF
RMCLLHPFQR DKPHGVRVPK MIGKLKFITT LGTIDVTGNS RSAMKELQKL TQLQRLGLIG
VTKHNSKHLC STLERLQDLR SLMVHSGDSL GRLDTVSPPP HHLETLKLYG SLGTLPRWIK
TLHNLQKLCL RTTLLDSDAV QIISKLPKLI MLRLLAKSIM VEEMEFQSDA FLKLELLQLD
RLENLMSVSF PGGALPNLEI LLVNNCNLLS GHVLRQFHKL PKIKKVLLDG STDLDRNERA
AAFKKHEEAK AEVIQKIRAQ AHIIRAAFAF KEAAAAARN
//
