ID A0A3B6GLX3_WHEAT Unreviewed; 335 AA.
AC A0A3B6GLX3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN ORFNames=CFC21_045439 {ECO:0000313|EMBL:KAF7034420.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS3D02G029600.1};
RN [1] {ECO:0000313|EMBL:KAF7034420.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7034420.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS3D02G029600.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS3D02G029600.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS3D02G029600.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7034420.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7034420.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the SINA (Seven in absentia) family.
CC {ECO:0000256|ARBA:ARBA00009119}.
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DR EMBL; CM022219; KAF7034420.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6GLX3; -.
DR STRING; 4565.A0A3B6GLX3; -.
DR PaxDb; 4565-Traes_3DS_A4694F6BB-1; -.
DR EnsemblPlants; TraesCS3D02G029600.1; TraesCS3D02G029600.1; TraesCS3D02G029600.
DR Gramene; TraesCAD_scaffold_075129_01G000100.1; TraesCAD_scaffold_075129_01G000100.1; TraesCAD_scaffold_075129_01G000100.
DR Gramene; TraesCLE_scaffold_059989_01G000500.1; TraesCLE_scaffold_059989_01G000500.1; TraesCLE_scaffold_059989_01G000500.
DR Gramene; TraesCS3D02G029600.1; TraesCS3D02G029600.1; TraesCS3D02G029600.
DR Gramene; TraesCS3D03G0053200.1; TraesCS3D03G0053200.1.CDS; TraesCS3D03G0053200.
DR Gramene; TraesPAR_scaffold_059604_01G000500.1; TraesPAR_scaffold_059604_01G000500.1; TraesPAR_scaffold_059604_01G000500.
DR Gramene; TraesRN3D0100058400.1; TraesRN3D0100058400.1; TraesRN3D0100058400.
DR Gramene; TraesROB_scaffold_054801_01G000100.1; TraesROB_scaffold_054801_01G000100.1; TraesROB_scaffold_054801_01G000100.
DR Gramene; TraesWEE_scaffold_117924_01G000300.1; TraesWEE_scaffold_117924_01G000300.1; TraesWEE_scaffold_117924_01G000300.
DR OMA; ARRMPDH; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000019116; Chromosome 3D.
DR Proteomes; UP000815260; Chromosome 3D.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR049548; Sina-like_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR013010; Znf_SIAH.
DR PANTHER; PTHR10315; E3 UBIQUITIN PROTEIN LIGASE SIAH; 1.
DR PANTHER; PTHR10315:SF126; RING-TYPE E3 UBIQUITIN TRANSFERASE; 1.
DR Pfam; PF21362; Sina_RING; 1.
DR Pfam; PF21361; Sina_ZnF; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 1.
DR PROSITE; PS51081; ZF_SIAH; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00455};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00455};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00455}.
FT DOMAIN 89..147
FT /note="SIAH-type"
FT /evidence="ECO:0000259|PROSITE:PS51081"
FT REGION 281..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 281..298
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..335
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 335 AA; 37430 MW; 21B01457D3DB5E9D CRC64;
MDGTSSNKRQ LEAQLEGDSN AKRHNVTMRL ETLDCSVCSE PLRPPIFQSS LGHFICLSCR
SEILDKKCHL CSAVTSFERC FGMEHVIKSV TVACSNAKYG CAEQIIYYQK EEHEKMCPNA
PCFCPESGCG FAGSTMALLG HMTGKHKCPL STCDDPSMVN VYLYLEPGLR VLHCHEDDQF
FLFNMASESF GHAISVVCVQ PRVTEPKFTC DLYYDSSTTD DSQNSCCKVR SSSLSDGLPT
GYDLIVPKGK VSDEGNGIML RATIREKRNV FYDSDSDEVP RALGRRKRNG RNPDCSDPNH
ERPVPLAARL IPDYSESEDE RPLAARFSKI RGYER
//
