ID A0A3B6H376_WHEAT Unreviewed; 375 AA.
AC A0A3B6H376;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Cysteine proteinase {ECO:0008006|Google:ProtNLM};
GN ORFNames=CFC21_049278 {ECO:0000313|EMBL:KAF7039235.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS3D02G407700.1.cds1};
RN [1] {ECO:0000313|EMBL:KAF7039235.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7039235.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS3D02G407700.1.cds1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS3D02G407700.1.cds1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS3D02G407700.1.cds1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7039235.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7039235.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM022219; KAF7039235.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6H376; -.
DR SMR; A0A3B6H376; -.
DR STRING; 4565.A0A3B6H376; -.
DR EnsemblPlants; TraesCS3D02G407700.1; TraesCS3D02G407700.1.cds1; TraesCS3D02G407700.
DR Gramene; TraesCAD_scaffold_008201_01G000200.1; TraesCAD_scaffold_008201_01G000200.1; TraesCAD_scaffold_008201_01G000200.
DR Gramene; TraesCLE_scaffold_021369_01G000100.1; TraesCLE_scaffold_021369_01G000100.1; TraesCLE_scaffold_021369_01G000100.
DR Gramene; TraesCS3D02G407700.1; TraesCS3D02G407700.1.cds1; TraesCS3D02G407700.
DR Gramene; TraesCS3D03G0898000.1; TraesCS3D03G0898000.1.CDS1; TraesCS3D03G0898000.
DR Gramene; TraesKAR3D01G0376960.1; cds.TraesKAR3D01G0376960.1; TraesKAR3D01G0376960.
DR Gramene; TraesPAR_scaffold_007764_01G000300.1; TraesPAR_scaffold_007764_01G000300.1; TraesPAR_scaffold_007764_01G000300.
DR Gramene; TraesROB_scaffold_029574_01G000300.1; TraesROB_scaffold_029574_01G000300.1; TraesROB_scaffold_029574_01G000300.
DR Gramene; TraesWEE_scaffold_025038_01G000300.1; TraesWEE_scaffold_025038_01G000300.1; TraesWEE_scaffold_025038_01G000300.
DR OMA; CSHIINH; -.
DR OrthoDB; 351182at2759; -.
DR Proteomes; UP000019116; Chromosome 3D.
DR Proteomes; UP000815260; Chromosome 3D.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0051603; P:proteolysis involved in protein catabolic process; IBA:GO_Central.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411:SF778; CYSTEINE ENDOPEPTIDASE; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..375
FT /note="Cysteine proteinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5039991370"
FT DOMAIN 46..102
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 134..353
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
FT REGION 353..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 375 AA; 40232 MW; 942F909D2E9F14D4 CRC64;
MGQLSKKLLV ASMVAAVLAV AAVELCGAIP LEDKDLESEE ALWDLYERWQ TAHRVPRHHA
EKHRRFGTFK SNAHFVHSHN KRGDRPYRLH LNRFGDMSQA EFRATFVGDL RRDTPATPPS
IPGFMYAAVN VSDLPPSVDW RQKGAVTGVK DQGKCGSCWA FSTVVSVEGI NAIRTGSLVS
LSEQELIDCD TADNEGCQGG LMDNAFEYIK SNGGLITEAA YPYRAAKGTC NVAGAAQNSP
VVVHIDGHQD VPANSEEALA QAVANQPVSV AVEASGKAFM FYSEGVFTGS CGTELDHGVA
VVGYGVAEDG KAYWTVKNSW GPSWGEQGYI RVEKDSGAAG GLCGIAMEAS YPVKTDSKPK
PTPAPRRALG ARESQ
//
