ID A0A3B6H6N2_WHEAT Unreviewed; 498 AA.
AC A0A3B6H6N2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Protein DETOXIFICATION {ECO:0000256|RuleBase:RU004914};
DE AltName: Full=Multidrug and toxic compound extrusion protein {ECO:0000256|RuleBase:RU004914};
GN ORFNames=CFC21_050370 {ECO:0000313|EMBL:KAF7040468.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS3D02G506100.1};
RN [1] {ECO:0000313|EMBL:KAF7040468.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7040468.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS3D02G506100.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS3D02G506100.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS3D02G506100.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7040468.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7040468.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000256|ARBA:ARBA00010199,
CC ECO:0000256|RuleBase:RU004914}.
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DR EMBL; CM022219; KAF7040468.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6H6N2; -.
DR SMR; A0A3B6H6N2; -.
DR STRING; 4565.A0A3B6H6N2; -.
DR EnsemblPlants; TraesCS3D02G506100.1; TraesCS3D02G506100.1; TraesCS3D02G506100.
DR Gramene; TraesCAD_scaffold_031381_01G000100.1; TraesCAD_scaffold_031381_01G000100.1; TraesCAD_scaffold_031381_01G000100.
DR Gramene; TraesCLE_scaffold_024956_01G000500.1; TraesCLE_scaffold_024956_01G000500.1; TraesCLE_scaffold_024956_01G000500.
DR Gramene; TraesCS3D02G506100.1; TraesCS3D02G506100.1; TraesCS3D02G506100.
DR Gramene; TraesCS3D03G1116500.1; TraesCS3D03G1116500.1.CDS; TraesCS3D03G1116500.
DR Gramene; TraesPAR_scaffold_025513_01G000100.1; TraesPAR_scaffold_025513_01G000100.1; TraesPAR_scaffold_025513_01G000100.
DR Gramene; TraesRN3D0101169500.1; TraesRN3D0101169500.1; TraesRN3D0101169500.
DR Gramene; TraesROB_scaffold_028715_01G000500.1; TraesROB_scaffold_028715_01G000500.1; TraesROB_scaffold_028715_01G000500.
DR Gramene; TraesWEE_scaffold_023579_01G000100.1; TraesWEE_scaffold_023579_01G000100.1; TraesWEE_scaffold_023579_01G000100.
DR Proteomes; UP000019116; Chromosome 3D.
DR Proteomes; UP000815260; Chromosome 3D.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR NCBIfam; TIGR00797; matE; 1.
DR PANTHER; PTHR11206; MULTIDRUG RESISTANCE PROTEIN; 1.
DR PANTHER; PTHR11206:SF272; PROTEIN DETOXIFICATION 40; 1.
DR Pfam; PF01554; MatE; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|RuleBase:RU004914};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Transmembrane {ECO:0000256|RuleBase:RU004914};
KW Transmembrane helix {ECO:0000256|RuleBase:RU004914}.
FT TRANSMEM 42..64
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 84..101
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 121..145
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 151..172
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 184..206
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 212..238
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 259..277
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 297..318
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 339..364
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 384..406
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 413..437
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 443..462
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
SQ SEQUENCE 498 AA; 53608 MW; 5CDA7F51ACDE94C1 CRC64;
MGGGDEHGAS ARLESILTDS SAPRAERVWA AGAIELGMLL RLAVPAVIMY MINFLMSMST
QIFSGHLGSL ELAAASLGNT GVQMFAYGLM LGMGSAVETL CGQAYGGHKY DMLGTYLQRS
AVILCCTGIP LAVIYAFSEP ILLLLGQSPE IARAASIFVY GLIPQIFAYA INFPIQKFLQ
AQSIVLPSAY ISTATLVLHL LLSWVVVYKV GLGLLGASLV LSLSWWIIVV AQFAYIIMSP
TCRRTWTGFT IKAFSGLPEF LKLSAASAVM LCLETWYYQV MVLIAGLLPN PELSLDSLSV
CLTISAWVFM ISIGFNAAAS VRVSNELGAG NPKSAFFSVW VVTVLSAIIA AVLAVVIMCF
RNYISYIFTE GERVSDAVAD LCPLLAITII LNGIQPVLSE ISGVAVGCGW QQFVAYVNVG
CYYIVGVPLG VLLGFVFNFG VKGLWGGMIG GTAMQTAILL WVTIRTDWSK EVEEAQKRLN
KWDDTKKEPL LVGVTDDN
//
