ID A0A3B6HUJ3_WHEAT Unreviewed; 558 AA.
AC A0A3B6HUJ3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Glucose-6-phosphate 1-dehydrogenase {ECO:0000256|RuleBase:RU362120};
DE EC=1.1.1.49 {ECO:0000256|RuleBase:RU362120};
GN ORFNames=CFC21_052056 {ECO:0000313|EMBL:KAF7042456.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS4A02G126200.1};
RN [1] {ECO:0000313|EMBL:KAF7042456.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7042456.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS4A02G126200.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS4A02G126200.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS4A02G126200.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7042456.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7042456.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the rate-limiting step of the oxidative pentose-
CC phosphate pathway, which represents a route for the dissimilation of
CC carbohydrates besides glycolysis. {ECO:0000256|RuleBase:RU362120}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-
CC lactone + H(+) + NADPH; Xref=Rhea:RHEA:15841, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57783, ChEBI:CHEBI:57955, ChEBI:CHEBI:58349,
CC ChEBI:CHEBI:61548; EC=1.1.1.49;
CC Evidence={ECO:0000256|RuleBase:RU362120};
CC -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step
CC 1/3. {ECO:0000256|RuleBase:RU362120}.
CC -!- SIMILARITY: Belongs to the glucose-6-phosphate dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009975, ECO:0000256|RuleBase:RU362120}.
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DR EMBL; CM022220; KAF7042456.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6HUJ3; -.
DR PaxDb; 4565-Traes_4BL_A33273FF8-3; -.
DR EnsemblPlants; TraesCS4A02G126200.1; TraesCS4A02G126200.1; TraesCS4A02G126200.
DR Gramene; TraesCAD_scaffold_057497_01G000200.1; TraesCAD_scaffold_057497_01G000200.1; TraesCAD_scaffold_057497_01G000200.
DR Gramene; TraesCLE_scaffold_078789_01G000200.1; TraesCLE_scaffold_078789_01G000200.1; TraesCLE_scaffold_078789_01G000200.
DR Gramene; TraesCS4A02G126200.1; TraesCS4A02G126200.1; TraesCS4A02G126200.
DR Gramene; TraesCS4A03G0264000.3; TraesCS4A03G0264000.3.CDS; TraesCS4A03G0264000.
DR Gramene; TraesPAR_scaffold_063920_01G000200.1; TraesPAR_scaffold_063920_01G000200.1; TraesPAR_scaffold_063920_01G000200.
DR Gramene; TraesROB_scaffold_113436_01G000200.1; TraesROB_scaffold_113436_01G000200.1; TraesROB_scaffold_113436_01G000200.
DR Gramene; TraesWEE_scaffold_057486_01G000200.1; TraesWEE_scaffold_057486_01G000200.1; TraesWEE_scaffold_057486_01G000200.
DR OMA; MLEPLWN; -.
DR UniPathway; UPA00115; UER00408.
DR Proteomes; UP000019116; Chromosome 4A.
DR Proteomes; UP000815260; Chromosome 4A.
DR GO; GO:0004345; F:glucose-6-phosphate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR HAMAP; MF_00966; G6PD; 1.
DR InterPro; IPR001282; G6P_DH.
DR InterPro; IPR022675; G6P_DH_C.
DR InterPro; IPR022674; G6P_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR NCBIfam; TIGR00871; zwf; 1.
DR PANTHER; PTHR23429; GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD; 1.
DR PANTHER; PTHR23429:SF4; INACTIVE GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE 4, CHLOROPLASTIC; 1.
DR Pfam; PF02781; G6PD_C; 1.
DR Pfam; PF00479; G6PD_N; 1.
DR PIRSF; PIRSF000110; G6PD; 1.
DR PRINTS; PR00079; G6PDHDRGNASE.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|RuleBase:RU362120};
KW Glucose metabolism {ECO:0000256|ARBA:ARBA00022526,
KW ECO:0000256|RuleBase:RU362120}; NADP {ECO:0000256|RuleBase:RU362120};
KW Oxidoreductase {ECO:0000256|RuleBase:RU362120};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116}.
FT DOMAIN 92..267
FT /note="Glucose-6-phosphate dehydrogenase NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF00479"
FT DOMAIN 270..554
FT /note="Glucose-6-phosphate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02781"
SQ SEQUENCE 558 AA; 63019 MW; 4D10639F3621BBB4 CRC64;
MATTVLAVRA SAAPAPPSLG AARFSPVAGP AVSLRTQCWI AAKMKLHKAL RRHGSQVQRK
LEIQGVGKIP DCFKVASLTG RMTRRNVQLA DATGELARNK VFPALFALYY SDFLPQNVAI
FGYSRKTLAD EDLRSMIEAN LTCRVDHHEN CEEKLNEFLK RTYYVDAGHD NIDGMAKLNS
KMAQIEGTCA ANRIFYLAVP QEALLDVALP LSDSAQTKHG WNRIIIEKPF GFTSLSSQRV
TQSLLSRFEE RQIYRIDHLL GKDLIENLTV LRFSNLVFEP LWSRKYIRNV QVVFSEETSA
ETQGRYFGNY GIIRDIVHSH ILQTIALFAM EPPVSLDGED IRDEKVKVLK SIRKVDIEDV
VLGQLKDTSG KVDRYTKSMT PTYFAAAMYI DNARWDGVPF LIKTGMGLME NRAEIRIQFH
HVPGNIYRER FGHDIDLDTN ELILRDLPEE AILLKVNNKV PGLGLQLDAS ELNLLYRDRY
DVEVPDSYEH LLLDVLDGDS HLFMRSDELA AAWSVLAPIL HEIDQKRVAP ELYEAGDKGP
INAYYLAAKH GVRWDDGC
//