ID A0A3B6HV22_WHEAT Unreviewed; 393 AA.
AC A0A3B6HV22;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Uroporphyrinogen decarboxylase {ECO:0000256|ARBA:ARBA00012288, ECO:0000256|RuleBase:RU000554};
DE EC=4.1.1.37 {ECO:0000256|ARBA:ARBA00012288, ECO:0000256|RuleBase:RU000554};
GN ORFNames=CFC21_052159 {ECO:0000313|EMBL:KAF7042601.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS4A02G136400.1};
RN [1] {ECO:0000313|EMBL:KAF7042601.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7042601.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS4A02G136400.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS4A02G136400.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS4A02G136400.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7042601.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7042601.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the decarboxylation of four acetate groups of
CC uroporphyrinogen-III to yield coproporphyrinogen-III.
CC {ECO:0000256|ARBA:ARBA00002448}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen
CC III; Xref=Rhea:RHEA:19865, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:57308, ChEBI:CHEBI:57309; EC=4.1.1.37;
CC Evidence={ECO:0000256|ARBA:ARBA00001082,
CC ECO:0000256|RuleBase:RU000554};
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.
CC {ECO:0000256|ARBA:ARBA00004804, ECO:0000256|RuleBase:RU000554}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the uroporphyrinogen decarboxylase family.
CC {ECO:0000256|ARBA:ARBA00009935, ECO:0000256|RuleBase:RU004169}.
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DR EMBL; CM022220; KAF7042601.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6HV22; -.
DR SMR; A0A3B6HV22; -.
DR STRING; 4565.A0A3B6HV22; -.
DR PaxDb; 4565-Traes_4AS_90CC29CAA-2; -.
DR EnsemblPlants; TraesCS4A02G136400.1; TraesCS4A02G136400.1; TraesCS4A02G136400.
DR Gramene; TraesCAD_scaffold_050266_01G000100.1; TraesCAD_scaffold_050266_01G000100.1; TraesCAD_scaffold_050266_01G000100.
DR Gramene; TraesCLE_scaffold_020631_01G000300.1; TraesCLE_scaffold_020631_01G000300.1; TraesCLE_scaffold_020631_01G000300.
DR Gramene; TraesCS4A02G136400.1; TraesCS4A02G136400.1; TraesCS4A02G136400.
DR Gramene; TraesCS4A03G0294300.1; TraesCS4A03G0294300.1.CDS; TraesCS4A03G0294300.
DR Gramene; TraesPAR_scaffold_058695_01G000100.1; TraesPAR_scaffold_058695_01G000100.1; TraesPAR_scaffold_058695_01G000100.
DR Gramene; TraesROB_scaffold_095252_01G000100.1; TraesROB_scaffold_095252_01G000100.1; TraesROB_scaffold_095252_01G000100.
DR Gramene; TraesWEE_scaffold_019637_01G000300.1; TraesWEE_scaffold_019637_01G000300.1; TraesWEE_scaffold_019637_01G000300.
DR OMA; KFRCAIA; -.
DR OrthoDB; 34606at2759; -.
DR UniPathway; UPA00251; UER00321.
DR Proteomes; UP000019116; Chromosome 4A.
DR Proteomes; UP000815260; Chromosome 4A.
DR GO; GO:0004853; F:uroporphyrinogen decarboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00717; URO-D; 1.
DR Gene3D; 3.20.20.210; -; 1.
DR HAMAP; MF_00218; URO_D; 1.
DR InterPro; IPR038071; UROD/MetE-like_sf.
DR InterPro; IPR006361; Uroporphyrinogen_deCO2ase_HemE.
DR InterPro; IPR000257; Uroporphyrinogen_deCOase.
DR NCBIfam; TIGR01464; hemE; 1.
DR PANTHER; PTHR21091; METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED; 1.
DR PANTHER; PTHR21091:SF169; UROPORPHYRINOGEN DECARBOXYLASE; 1.
DR Pfam; PF01208; URO-D; 1.
DR SUPFAM; SSF51726; UROD/MetE-like; 1.
DR PROSITE; PS00906; UROD_1; 1.
DR PROSITE; PS00907; UROD_2; 1.
PE 3: Inferred from homology;
KW Chlorophyll biosynthesis {ECO:0000256|ARBA:ARBA00023171};
KW Decarboxylase {ECO:0000256|ARBA:ARBA00022793,
KW ECO:0000256|RuleBase:RU000554};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000554};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244,
KW ECO:0000256|RuleBase:RU000554};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116}.
FT DOMAIN 68..77
FT /note="Uroporphyrinogen decarboxylase (URO-D)"
FT /evidence="ECO:0000259|PROSITE:PS00906"
FT DOMAIN 188..204
FT /note="Uroporphyrinogen decarboxylase (URO-D)"
FT /evidence="ECO:0000259|PROSITE:PS00907"
SQ SEQUENCE 393 AA; 42951 MW; 418F30C6EA60E462 CRC64;
MATACPPLSL PSTSLLRKTT RAGPARQPLP SVRCSAVGEA VAEAAVAGTA EEPLLVSAIK
GKKVERPPVW LMRQAGRYMK SYQNLCEKYP LFRERSENVD LVVEISLQPW KVFKPDGVIL
FSDILTPLPG MNIPFDIVKG KGPVIYDPLR TAAAVNEVRE FVPEEWVPYV GQALNLLRGE
VKNEAAVLGF VGAPFTLASY CVEGGSSKNF SKIKRMAFAE PAILHNLLQK FTTSMASYIK
YQADNGAQAV QIFDSWATEL SPVDFEEFSL PYLKQIVDSV KETHPDLPLI LYASGSGGLL
ERLPLTGVDV VSLDWTVDMA EGRKRLGSNI AVQGNVDPGV LFGSKEFITK RIYDTVQKAG
SEGHVLNLGH GIKVGTPEEN VAHFFEVAKG IRY
//
