ID A0A3B6HWT4_WHEAT Unreviewed; 802 AA.
AC A0A3B6HWT4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
GN ORFNames=CFC21_097444 {ECO:0000313|EMBL:KAF7095225.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS4A02G271700.2};
RN [1] {ECO:0000313|EMBL:KAF7095225.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7095225.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS4A02G271700.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS4A02G271700.2};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS4A02G271700.2}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7095225.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7095225.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in the transport of sterols.
CC {ECO:0000256|ARBA:ARBA00003361}.
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DR EMBL; CM022229; KAF7095225.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6HWT4; -.
DR EnsemblPlants; TraesCS4A02G271700.2; TraesCS4A02G271700.2; TraesCS4A02G271700.
DR Gramene; TraesCS4A02G271700.2; TraesCS4A02G271700.2; TraesCS4A02G271700.
DR Gramene; TraesCS4A03G0704200.1; TraesCS4A03G0704200.1.CDS; TraesCS4A03G0704200.
DR OMA; CESKEWV; -.
DR Proteomes; UP000019116; Chromosome 4A.
DR Proteomes; UP000815260; Chromosome 7A.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd13294; PH_ORP_plant; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972:SF216; OXYSTEROL-BINDING PROTEIN HOMOLOG 3; 1.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF15413; PH_11; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 84..220
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 25..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 138..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 307..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 364..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..44
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..339
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..378
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 802 AA; 89965 MW; 35B6B17E289F3CE5 CRC64;
MHPFCCVPPV PVSPAAAAAA ASSAPPAVAG LPPAMPPPPP PPLQPARCCS SSSSSAARAR
VAGVGVGGGP SSPPDGVRLN EIVGGGISGV LYKWVNYGRG WRPRWFALSD GVLSYYKIHG
PDRIDLSRDT DRGAKVIGED SLRRLARPSS ASAPHSNGHG HHQTPRKPLG EIHLKVSTVR
ESRSDDRRFS IFSGTKRLHL RAETREDRAA WLEALRATKE MFPRMSTSEM VGPGDTAAAA
AVSTERLKKR LQQEGVSDAA IADSERIVRE EFEALHKQLV LLKQKQALLL DTLRHLETEK
VDLENTLVDE SQRQSKEYGS ASRPRNEKLS GSGSESDDYN EPQDPAEEET DDEENIYFDT
TDFLSSSSFK SSGSDFQRSE AGSDDEDDYP MDGIDPSMKS VGINYPYVRR RKKLPDPVEK
EKGVSLWSMI KDNIGKDLTK VCLPVYFNEP LSSLQKCFED LEYSYLIDRA YEWGKRGDSL
MRILSVAAFA VSGYASTDGR SCKPFNPLLG ETYEADYPDK GLRFFSEKVS HHPMVVACHC
EGNGWRFWAD SNLKSKFWGR SIQLDPVGVL TLEFDDGEVF QWSKVTTSIY NLILGKLYCD
HYGTMRIQGN REYSCKLKFK EQSIIDRNPH QVQGVIQDRS GRTVATLFGK WDESMHYVMG
DCFGKGKGSE NFSEAHLLWK RSKPPKFPTR YNFTSFAITL NELTPGLKEK LPPTDSRLRP
DQRCLENGEY ERANAEKLRL EQRQRQARKM QESGWKPRWF AKDKGSDTYR YLGGYWESRE
KSSWEGCPDI FGQLPNDLMI TD
//
