ID   A0A3B6IP70_WHEAT        Unreviewed;       496 AA.
AC   A0A3B6IP70;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=MPN domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Triticum aestivum (Wheat).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX   NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS4B02G057300.2};
RN   [1] {ECO:0000313|EnsemblPlants:TraesCS4B02G057300.2}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Chinese Spring
RC   {ECO:0000313|EnsemblPlants:TraesCS4B02G057300.2};
RX   PubMed=30115783; DOI=10.1126/science.aar7191;
RG   International wheat genome sequencing consortium (IWGSC);
RT   "Shifting the limits in wheat research and breeding using a fully annotated
RT   reference genome.";
RL   Science 361:EAAR7191-EAAR7191(2018).
RN   [2] {ECO:0000313|EnsemblPlants:TraesCS4B02G057300.2}
RP   IDENTIFICATION.
RG   EnsemblPlants;
RL   Submitted (OCT-2018) to UniProtKB.
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DR   AlphaFoldDB; A0A3B6IP70; -.
DR   EnsemblPlants; TraesCS4B02G057300.2; TraesCS4B02G057300.2; TraesCS4B02G057300.
DR   Gramene; TraesCS4B02G057300.2; TraesCS4B02G057300.2; TraesCS4B02G057300.
DR   Gramene; TraesCS4B03G0125400.1; TraesCS4B03G0125400.1.CDS; TraesCS4B03G0125400.
DR   Gramene; TraesRN4B0100130200.1; TraesRN4B0100130200.1; TraesRN4B0100130200.
DR   OMA; THYSYQP; -.
DR   Proteomes; UP000019116; Chromosome 4B.
DR   GO; GO:0061578; F:K63-linked deubiquitinase activity; IEA:InterPro.
DR   GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR   CDD; cd08066; MPN_AMSH_like; 1.
DR   Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 2.
DR   Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 1.
DR   InterPro; IPR000555; JAMM/MPN+_dom.
DR   InterPro; IPR044098; STAMBP/STALP-like_MPN.
DR   InterPro; IPR015063; USP8_dimer.
DR   PANTHER; PTHR12947; AMSH-LIKE PROTEASE; 1.
DR   PANTHER; PTHR12947:SF18; AMSH-LIKE UBIQUITIN THIOESTERASE 3; 1.
DR   Pfam; PF01398; JAB; 1.
DR   Pfam; PF08969; USP8_dimer; 1.
DR   SUPFAM; SSF102712; JAB1/MPN domain; 1.
DR   SUPFAM; SSF140856; USP8 N-terminal domain-like; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000019116}.
FT   DOMAIN          16..109
FT                   /note="USP8 dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF08969"
FT   DOMAIN          338..419
FT                   /note="JAB1/MPN/MOV34 metalloenzyme"
FT                   /evidence="ECO:0000259|Pfam:PF01398"
FT   REGION          157..178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   496 AA;  55558 MW;  A5A10FB89FDA3450 CRC64;
     MAMASPWQAG RRINIEGMAR PVAVDHRISL PYYFRIADNL LRQANIYREE KNLIDLYIIL
     LRYSSLLSET IPKHRDYHAF KSREKEFLKK GPHNSDKLLN VISELESLKP IVKQQIAELN
     RRAAEERNGP HETYAGNGAS SRTDQLAASP YMVQPAFGSS TGPLQKPSSR WNHQEEPDRH
     LVKSYASLPY PKDETLSRHS ILGPNGLHGQ WTRPVSGVKV QYPSYPELNQ SNIPSLVPAI
     LNQNDSHDPH TTSLDGLTNN NGDMQSVLSL DDGQWSLPVK EPASVSPASF EEEFSQLNIR
     QPNPPPVLAQ VHPERRPISP SRVADPRPGL ATSDTGRFQN LHVPVALMES FLRLAEANTA
     KNLETCGILA GNLKKRTFYV TTLIIPKQES TSDSCQATNE EEIFEVQDKG SLFTLGWIHV
     MLPEAIAIVM APTDTTRKHG IFHLTDPGGM GVIHDCQETG FHPHEEPLDG TSIYEHCSHV
     YMNPSVKFDM VDLRRV
//