ID A0A3B6IQ65_WHEAT Unreviewed; 499 AA.
AC A0A3B6IQ65;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Reticulon-like protein {ECO:0000256|RuleBase:RU363132};
GN ORFNames=CFC21_057466 {ECO:0000313|EMBL:KAF7048775.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS4B02G151900.2};
RN [1] {ECO:0000313|EMBL:KAF7048775.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7048775.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS4B02G151900.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS4B02G151900.2};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS4B02G151900.2}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7048775.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7048775.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU363132}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC ECO:0000256|RuleBase:RU363132}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219}.
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DR EMBL; CM022221; KAF7048775.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6IQ65; -.
DR PaxDb; 4565-Traes_4BS_E5F2918D0-1; -.
DR EnsemblPlants; TraesCS4B02G151900.2; TraesCS4B02G151900.2; TraesCS4B02G151900.
DR Gramene; TraesCS4B02G151900.2; TraesCS4B02G151900.2; TraesCS4B02G151900.
DR Gramene; TraesCS4B03G0382600.1; TraesCS4B03G0382600.1.CDS; TraesCS4B03G0382600.
DR Proteomes; UP000019116; Chromosome 4B.
DR Proteomes; UP000815260; Chromosome 4B.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003388; Reticulon.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR Pfam; PF02453; Reticulon; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS50845; RETICULON; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU363132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363132};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU363132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363132}.
FT TRANSMEM 337..356
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363132"
FT TRANSMEM 362..381
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363132"
FT TRANSMEM 429..447
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363132"
FT DOMAIN 322..478
FT /note="Reticulon"
FT /evidence="ECO:0000259|PROSITE:PS50845"
SQ SEQUENCE 499 AA; 55535 MW; 0AED621A6B42B00E CRC64;
MDAAEASARW CVVTGGRGFA ARHLVLMLLR SGEWRVRVAD LAQVISLDLD EEQGILGAAI
REGQAVYASA DLRDKAQLAK DFEGAEVVFH MAAPDSSINN FHLHYSVNVE GTKNVIDACI
HCKVKRLIYT SSPSVVFDGV HGIFNADESM PYPDKYIIGD GNNYYDFTYV ENVAYGHVCA
DKTLSSEDGA KRAAGKAYFV TNVEPIKFWE FMSLLLDGLG YQRPSIKIPV SVMMPLAHVV
EWTYKSFCKY GMKVPQLTPS RIRLLSCNRT FSCSRAKDQL GYEPIVSLKD GLKRTIESYS
HMQAQNQRSI SKTSILLGNG NVAKTLLWED SKQTMTVLLL LAVIYYQLFT CGYTIITAMA
KIFSLTALFL FIHGMLPANV FGHKIEKLEP SNFHISQVEA HHIACSVSSS WNSLVGVLKS
LCRGNDWPLF LKVVFFLLVV SILSAMSSEA AFKIGIPLIF IGFKAYEKWE DTIDSLVGDA
CSFVLQFTPI QISSRQKQT
//
