ID A0A3B6ISC3_WHEAT Unreviewed; 766 AA.
AC A0A3B6ISC3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN ORFNames=CFC21_058043 {ECO:0000313|EMBL:KAF7049519.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS4B02G206900.1};
RN [1] {ECO:0000313|EMBL:KAF7049519.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7049519.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS4B02G206900.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS4B02G206900.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS4B02G206900.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7049519.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7049519.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; CM022221; KAF7049519.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6ISC3; -.
DR SMR; A0A3B6ISC3; -.
DR STRING; 4565.A0A3B6ISC3; -.
DR EnsemblPlants; TraesCS4B02G206900.1; TraesCS4B02G206900.1; TraesCS4B02G206900.
DR Gramene; TraesCS4B02G206900.1; TraesCS4B02G206900.1; TraesCS4B02G206900.
DR Gramene; TraesCS4B03G0574700.1; TraesCS4B03G0574700.1.CDS; TraesCS4B03G0574700.
DR OMA; LEMEHIM; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000019116; Chromosome 4B.
DR Proteomes; UP000815260; Chromosome 4B.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd21037; MLKL_NTD; 1.
DR CDD; cd16664; RING-Ubox_PUB; 1.
DR Gene3D; 1.20.930.20; Adaptor protein Cbl, N-terminal domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR036537; Adaptor_Cbl_N_dom_sf.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR008709; Neurochondrin.
DR InterPro; IPR045210; RING-Ubox_PUB.
DR InterPro; IPR003613; Ubox_domain.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR23315:SF358; RING-TYPE E3 UBIQUITIN TRANSFERASE; 1.
DR PANTHER; PTHR23315; U BOX DOMAIN-CONTAINING; 1.
DR Pfam; PF00514; Arm; 2.
DR Pfam; PF05536; Neurochondrin; 1.
DR Pfam; PF04564; U-box; 1.
DR SMART; SM00185; ARM; 5.
DR SMART; SM00504; Ubox; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50176; ARM_REPEAT; 2.
DR PROSITE; PS51698; U_BOX; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000019116}.
FT DOMAIN 342..416
FT /note="U-box"
FT /evidence="ECO:0000259|PROSITE:PS51698"
FT REPEAT 479..521
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 602..644
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REGION 1..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 79..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 766 AA; 82028 MW; 080F30D0645E037F CRC64;
MPAAPAVPIS ARGVRLTAGT GGSQGGAERS SRRPPPQIPF LCTSPVSPPL RPHDAAGGAA
AMDEEASTKA AAAAAVATAA KAATPPTPSG SGSPEGGKEE VGDLVERVAE LVDEIAVISD
FRNAYRRQFC NLSRRIRLLA PMMEEVKEGP RPLPEASLAA LRQLRDALAG ARELLRLGSN
GSKIFLVLER EKIMQTFQDI TSRLEQALAG ISFDELGISD EVREQVELVH AQFKRAKERP
DTSDDILFND LISAYNSSTN DNADPDIIQR LSEKLQLVTI YDLNQESLAL HEMASGGDPG
AVVENMSMLL KKIKDFVQTQ DPIGIPASTT NPSRDDNLTS PVVPDDFRCP ISLDLMKDPV
IVSTGQTYER GCIERWLEAG HDTCPKTQQK LPNKSLTPNY VLRSLIAQWC EANGVEPPKR
PAQPNTTEAT CTASEHSKVI ELLQKLSSQN LADQRGAAGM LRQLAKRSAE NRACIGEAGA
IPILVSLLPT TDVSTQEHVV TALLNLSIYE ENKARIITSG AVPGIVHVLK RGSMEARENS
AATLFSLSLV DENKVTIGAS GAIPALVLLL GNGSQRGKKD AATALFNLCI YQGNKGKAVR
AGLVPILLEL LTETESGMVD EALAILAILS SHPEGKAAIS AAAAIPILVG VIRNGSSWNK
ENAAAVLVHL CNGEQQQQHL AEAQEQGIVT LLEELAESGI DRGKRKAIQL LERMNRFLKQ
QSQAQGDAMA QAHTQSQTLS QVLVQAQADT QLEESLPPTS SHLPER
//
