ID A0A3B6IT03_WHEAT Unreviewed; 617 AA.
AC A0A3B6IT03;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Glucose-6-phosphate 1-dehydrogenase {ECO:0000256|RuleBase:RU362120};
DE EC=1.1.1.49 {ECO:0000256|RuleBase:RU362120};
GN ORFNames=CFC21_070515 {ECO:0000313|EMBL:KAF7064096.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS4B02G178700.1};
RN [1] {ECO:0000313|EMBL:KAF7064096.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7064096.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS4B02G178700.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS4B02G178700.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS4B02G178700.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7064096.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7064096.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the rate-limiting step of the oxidative pentose-
CC phosphate pathway, which represents a route for the dissimilation of
CC carbohydrates besides glycolysis. {ECO:0000256|RuleBase:RU362120}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-
CC lactone + H(+) + NADPH; Xref=Rhea:RHEA:15841, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57783, ChEBI:CHEBI:57955, ChEBI:CHEBI:58349,
CC ChEBI:CHEBI:61548; EC=1.1.1.49;
CC Evidence={ECO:0000256|RuleBase:RU362120};
CC -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step
CC 1/3. {ECO:0000256|RuleBase:RU362120}.
CC -!- SIMILARITY: Belongs to the glucose-6-phosphate dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009975, ECO:0000256|RuleBase:RU362120}.
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DR EMBL; CM022224; KAF7064096.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6IT03; -.
DR SMR; A0A3B6IT03; -.
DR STRING; 4565.A0A3B6IT03; -.
DR EnsemblPlants; TraesCS4B02G178700.1; TraesCS4B02G178700.1; TraesCS4B02G178700.
DR Gramene; TraesCAD_scaffold_009151_01G000200.1; TraesCAD_scaffold_009151_01G000200.1; TraesCAD_scaffold_009151_01G000200.
DR Gramene; TraesCS4B02G178700.1; TraesCS4B02G178700.1; TraesCS4B02G178700.
DR Gramene; TraesCS4B03G0503200.1; TraesCS4B03G0503200.1.CDS; TraesCS4B03G0503200.
DR Gramene; TraesKAR4B01G0264190.1; cds.TraesKAR4B01G0264190.1; TraesKAR4B01G0264190.
DR Gramene; TraesPAR_scaffold_006734_01G000200.1; TraesPAR_scaffold_006734_01G000200.1; TraesPAR_scaffold_006734_01G000200.
DR Gramene; TraesROB_scaffold_044628_01G000200.1; TraesROB_scaffold_044628_01G000200.1; TraesROB_scaffold_044628_01G000200.
DR Gramene; TraesWEE_scaffold_007222_01G000200.1; TraesWEE_scaffold_007222_01G000200.1; TraesWEE_scaffold_007222_01G000200.
DR OMA; GSHIKNQ; -.
DR OrthoDB; 312822at2759; -.
DR UniPathway; UPA00115; UER00408.
DR Proteomes; UP000019116; Chromosome 4B.
DR Proteomes; UP000815260; Chromosome 5B.
DR GO; GO:0004345; F:glucose-6-phosphate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR HAMAP; MF_00966; G6PD; 1.
DR InterPro; IPR001282; G6P_DH.
DR InterPro; IPR022675; G6P_DH_C.
DR InterPro; IPR022674; G6P_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR NCBIfam; TIGR00871; zwf; 1.
DR PANTHER; PTHR23429; GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD; 1.
DR PANTHER; PTHR23429:SF4; INACTIVE GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE 4, CHLOROPLASTIC; 1.
DR Pfam; PF02781; G6PD_C; 1.
DR Pfam; PF00479; G6PD_N; 1.
DR PRINTS; PR00079; G6PDHDRGNASE.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|RuleBase:RU362120};
KW Glucose metabolism {ECO:0000256|ARBA:ARBA00022526,
KW ECO:0000256|RuleBase:RU362120}; NADP {ECO:0000256|RuleBase:RU362120};
KW Oxidoreductase {ECO:0000256|RuleBase:RU362120};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116}.
FT DOMAIN 148..326
FT /note="Glucose-6-phosphate dehydrogenase NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF00479"
FT DOMAIN 329..613
FT /note="Glucose-6-phosphate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02781"
SQ SEQUENCE 617 AA; 69102 MW; 7BA04A770625925D CRC64;
MVTTVLAVTA SAAPAPPSLG AARFSPVAGP AVNFRPQVCG LRCWMAAKMK LQKALRSHGW
QVQRKLGIRG DGQIPDCFEV ASRTGKITRR NVQPADETGG NNSIDDKSSM HLGLNHSEAD
RPVLEEGVVL FDNFDDQPES VPSLCIAVIG ATGELARSKV FPALFALYYS GFLPQNVAIF
GYSRKTLADE DLRSMIEANL TCRVDHHENC EEKLNEFLKR TYYVDAGHDN KDGMAKLNSK
MAQIEGTCAA NRIFYLAVPQ EALLDVALPL SDSAQTKHGW NRIIIEKPFG FTSLSSQRVT
QSLLSRFEEK QIYRIDHLLG KDLIENLTVL RFSNLVFEPL WSRKYIRNVQ VVFSEETSAE
TQGRYFGNYG IIRDIVHSHI LQTIALFAME PPVSLDGEDI RDEKVKVLRS MRKVDIEDVV
LGQIKDTSGD VDRYTKSMTP TYFAAAMYID NARWDGVPFL IKTGMGLMEN RAEIRIQFHH
VPGNIYRERF GHDIDLDTNE LVLRDLPEEA ILLKVNNKVP GLGLQLDASE LNLLYRDRYD
VEVPDSYEHL LLGVVDGDSH LFMRSDELAA AWSVLAPILH EIDQKSVAPE LYEAGDKGPI
NAYYLAAKHG VRWDDGC
//
