ID A0A3B6IT36_WHEAT Unreviewed; 409 AA.
AC A0A3B6IT36;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=GPN-loop GTPase {ECO:0000256|RuleBase:RU365059};
DE EC=3.6.5.- {ECO:0000256|RuleBase:RU365059};
GN ORFNames=CFC21_057788 {ECO:0000313|EMBL:KAF7049216.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS4B02G180800.1};
RN [1] {ECO:0000313|EMBL:KAF7049216.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7049216.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS4B02G180800.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS4B02G180800.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS4B02G180800.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7049216.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7049216.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Small GTPase required for proper nuclear import of RNA
CC polymerase II (RNAPII). May act at an RNAP assembly step prior to
CC nuclear import. {ECO:0000256|RuleBase:RU365059}.
CC -!- SUBUNIT: Binds to RNA polymerase II. {ECO:0000256|RuleBase:RU365059}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU365059}.
CC Nucleus {ECO:0000256|RuleBase:RU365059}.
CC -!- SIMILARITY: Belongs to the GPN-loop GTPase family.
CC {ECO:0000256|ARBA:ARBA00005290, ECO:0000256|RuleBase:RU365059}.
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DR EMBL; CM022221; KAF7049216.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6IT36; -.
DR PaxDb; 4565-Traes_4BL_DFD8B778D-1; -.
DR EnsemblPlants; TraesCS4B02G180800.1; TraesCS4B02G180800.1; TraesCS4B02G180800.
DR Gramene; TraesCAD_scaffold_034854_01G000100.1; TraesCAD_scaffold_034854_01G000100.1; TraesCAD_scaffold_034854_01G000100.
DR Gramene; TraesCLE_scaffold_058274_01G000100.1; TraesCLE_scaffold_058274_01G000100.1; TraesCLE_scaffold_058274_01G000100.
DR Gramene; TraesCS4B02G180800.1; TraesCS4B02G180800.1; TraesCS4B02G180800.
DR Gramene; TraesCS4B03G0507600.2; TraesCS4B03G0507600.2.CDS; TraesCS4B03G0507600.
DR Gramene; TraesPAR_scaffold_072047_01G000100.1; TraesPAR_scaffold_072047_01G000100.1; TraesPAR_scaffold_072047_01G000100.
DR Gramene; TraesROB_scaffold_032943_01G000100.1; TraesROB_scaffold_032943_01G000100.1; TraesROB_scaffold_032943_01G000100.
DR Gramene; TraesWEE_scaffold_148653_01G000100.1; TraesWEE_scaffold_148653_01G000100.1; TraesWEE_scaffold_148653_01G000100.
DR OMA; QCQNPQI; -.
DR Proteomes; UP000019116; Chromosome 4B.
DR Proteomes; UP000815260; Chromosome 4B.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR CDD; cd17870; GPN1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR004130; Gpn.
DR InterPro; IPR030230; Gpn1/Npa3/XAB1.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR21231:SF8; GPN-LOOP GTPASE 1; 1.
DR PANTHER; PTHR21231; XPA-BINDING PROTEIN 1-RELATED; 1.
DR Pfam; PF03029; ATP_bind_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU365059};
KW GTP-binding {ECO:0000256|RuleBase:RU365059};
KW Hydrolase {ECO:0000256|RuleBase:RU365059};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU365059};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116}.
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 315..354
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 16..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..403
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 409 AA; 45317 MW; 600973A144379EB8 CRC64;
MDVDSEPSAE SKPAQMDLED QADAKGKGKA DAAEEEKGKG KGKGDELADS IGSLSIGPGR
ANFKKKPVII LVIGMAGTGK TTFMHRLVCH MQASANMRGY VLNLDPAVMT LPFGANIDIR
DTVRYKEVMK EYGLGPNGGI LTSLNLFSTK FDEVISVIEK RADQLDYVLV DTPGQIEIFT
WSASGAIITE AFASTFPTVV AYVVDTPRST SPVTFMSNMM YACSILYKTR LPLVLTFNKV
DVAKHEFALE WMQDFEAFQT ALDSDSSYTS SFTRSLSLVL DEFYNNLRSV GVSAVSGTGI
DAFFEAIEAS TNEYMETYRA DLDKRIAEKE RLEAERRNEN MERLRRDMEK SKGQTVVLST
GLKDKTPASE MMGDADEEEE EEALEDFRIS EDDDDEDEGE DDEVTHFGF
//
