ID A0A3B6IUL5_WHEAT Unreviewed; 907 AA.
AC A0A3B6IUL5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=DNA (cytosine-5)-methyltransferase {ECO:0000313|EnsemblPlants:TraesCS4B02G201800.4};
GN ORFNames=CFC21_057992 {ECO:0000313|EMBL:KAF7049464.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS4B02G201800.4};
RN [1] {ECO:0000313|EMBL:KAF7049464.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7049464.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS4B02G201800.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS4B02G201800.4};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS4B02G201800.4}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7049464.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7049464.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-
CC methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:13681, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:11370,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:85452, ChEBI:CHEBI:85454; EC=2.1.1.37;
CC Evidence={ECO:0000256|ARBA:ARBA00000743};
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DR EMBL; CM022221; KAF7049464.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6IUL5; -.
DR EnsemblPlants; TraesCS4B02G201800.4; TraesCS4B02G201800.4; TraesCS4B02G201800.
DR Gramene; TraesCS4B02G201800.4; TraesCS4B02G201800.4; TraesCS4B02G201800.
DR Gramene; TraesCS4B03G0563200.4; TraesCS4B03G0563200.4.CDS; TraesCS4B03G0563200.
DR Proteomes; UP000019116; Chromosome 4B.
DR Proteomes; UP000815260; Chromosome 4B.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd18635; CD_CMT3_like; 1.
DR Gene3D; 2.30.30.490; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR023779; Chromodomain_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR10629; CYTOSINE-SPECIFIC METHYLTRANSFERASE; 1.
DR PANTHER; PTHR10629:SF34; DNA (CYTOSINE-5)-METHYLTRANSFERASE CMT2; 1.
DR Pfam; PF01426; BAH; 1.
DR Pfam; PF00385; Chromo; 1.
DR SMART; SM00439; BAH; 1.
DR SMART; SM00298; CHROMO; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51038; BAH; 1.
DR PROSITE; PS00598; CHROMO_1; 1.
DR PROSITE; PS50013; CHROMO_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 579..696
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT DOMAIN 838..903
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT REGION 19..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 48..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 140..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 187..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 467..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..248
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..265
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 907 AA; 98665 MW; FD7B6CBF83C858E3 CRC64;
MWSPPRGFDV GAEFAAAAAG PDPLVDDGGG PWDGAEWRST GLVAGEGVSA TTRAPSPPTA
APGFAEFEPP ASDSSEGVPG VRPLEHLDDY SRMPESPSTP VAVDMREKLV FVSDSTPVPE
SPPSPWGSCL EANLEENAPC TLNTMSSPPQ LPPDDDDLVE AEDAPKYFSP SDNIASASMA
AVDLNAEYDP KGNADGCGTS GAASTNDTSL WGSRRTAKTM AAANATPSEP KARSSRSSKR
RPVDSDLGRS SVRHNLSVST TKPIKETTTT APDIVDKLIK EITGTAPNTV DKPIKEATTT
APATVDKPIK GTTTTSADTV DKLIKETTTT SPDIVDLCNR VEQHRSAENV MQSTSSGHEN
KGGGLSNQIV VALPAVNYRS AKRGGVSVRA PRKTKTAVKA SLVDSDSVPP ISPVVNSEPS
MHKAESNPHV RPSKYDLDPE NCLPSDKVDS SGIVPCNAGL MSAESHVVSE MPQQHDGKSS
KPPRAKRARV STDPNNSPKV IMDKKLVDLE MVDSVNESCC FVGEAVPEEE ARQRWPHRYE
KNHHFVEKDK GSDIQPFANA GNAVLDVKCH YLQASISGST LCIGDCAFVK GPEGKANYIG
KILEFFETVA GEYYCRVQWF FRAEDTIMED QAQSHDPRRV FYSDLKDDNA LDCIVSKVSI
VQVSPCVDNQ SKSIPSSQYY YDMKYSQNYS TFSTLEMEDT HAKLQSSQVS SISMKKEDFN
KTQKSHVPNK KDLSLLDLYC GCGGMSTGLC LGARGGGVNL VTRWAVDDDE VACESFRMNH
PETRVRNETT DDFLELLKEW QKLCKQYVKE SEVKDNADAI TEFGNGTPDD SAVPPEELEV
WKLVDICFGD PNNVRKRCLY FKVRWKGYGP NDDTWEPIEG LGNCNDAIKD FVIEDKILSP
KKETKHR
//
