ID A0A3B6IZZ5_WHEAT Unreviewed; 235 AA.
AC A0A3B6IZZ5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=rRNA N-glycosylase {ECO:0000256|RuleBase:RU004915};
DE EC=3.2.2.22 {ECO:0000256|RuleBase:RU004915};
GN ORFNames=CFC21_059847 {ECO:0000313|EMBL:KAF7051625.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS4B02G388100.1.cds1};
RN [1] {ECO:0000313|EMBL:KAF7051625.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7051625.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS4B02G388100.1.cds1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS4B02G388100.1.cds1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS4B02G388100.1.cds1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7051625.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7051625.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endohydrolysis of the N-glycosidic bond at one specific
CC adenosine on the 28S rRNA.; EC=3.2.2.22;
CC Evidence={ECO:0000256|RuleBase:RU004915};
CC -!- SIMILARITY: Belongs to the ribosome-inactivating protein family.
CC {ECO:0000256|RuleBase:RU004915}.
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DR EMBL; CM022221; KAF7051625.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6IZZ5; -.
DR EnsemblPlants; TraesCS4B02G388100.1; TraesCS4B02G388100.1.cds1; TraesCS4B02G388100.
DR Gramene; TraesCLE_scaffold_030061_01G000300.1; TraesCLE_scaffold_030061_01G000300.1; TraesCLE_scaffold_030061_01G000300.
DR Gramene; TraesCS4B02G388100.1; TraesCS4B02G388100.1.cds1; TraesCS4B02G388100.
DR Gramene; TraesCS4B03G0990500.1; TraesCS4B03G0990500.1.CDS1; TraesCS4B03G0990500.
DR Gramene; TraesPAR_scaffold_030804_01G000300.1; TraesPAR_scaffold_030804_01G000300.1; TraesPAR_scaffold_030804_01G000300.
DR OMA; RTDKWED; -.
DR OrthoDB; 374169at2759; -.
DR Proteomes; UP000019116; Chromosome 4B.
DR Proteomes; UP000815260; Chromosome 4B.
DR GO; GO:0030598; F:rRNA N-glycosylase activity; IEA:UniProtKB-EC.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0017148; P:negative regulation of translation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.420.10; Ricin (A subunit), domain 1; 1.
DR InterPro; IPR036041; Ribosome-inact_prot_sf.
DR InterPro; IPR001574; Ribosome_inactivat_prot.
DR InterPro; IPR016138; Ribosome_inactivat_prot_sub1.
DR PANTHER; PTHR33453; -; 1.
DR PANTHER; PTHR33453:SF28; RRNA N-GLYCOSYLASE; 1.
DR Pfam; PF00161; RIP; 1.
DR SUPFAM; SSF56371; Ribosome inactivating proteins (RIP); 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|RuleBase:RU004915};
KW Plant defense {ECO:0000256|RuleBase:RU004915};
KW Protein synthesis inhibitor {ECO:0000256|RuleBase:RU004915};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Signal {ECO:0000256|SAM:SignalP}; Toxin {ECO:0000256|RuleBase:RU004915}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..235
FT /note="rRNA N-glycosylase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5039991981"
SQ SEQUENCE 235 AA; 25505 MW; 4D928D5186575D39 CRC64;
MAAFLLFLLL ALAASSSEHG GAVAVADDPP AALTILTLHG SPENTSLAVQ THDLSLAGFT
DESLHWHAFP GHEHLIPTSK PLPFGSSYSE LIGGLANLPG LPLGRDAMVQ AVRVLSAYDP
AADVEPVKRA LAAVKVMICE SGRLKPVREA VRSGWDSESR VAPEHLPYIE HWDTMSYEII
RANRTDKWED GPFTKMLETQ ANIRSKEEAV AVMNVLMDAD FEQVLKAHAI PINLQ
//
