ID A0A3B6JE47_WHEAT Unreviewed; 328 AA.
AC A0A3B6JE47;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KAF7052213.1, ECO:0000313|EnsemblPlants:TraesCS4D02G037400.1};
GN ORFNames=CFC21_060337 {ECO:0000313|EMBL:KAF7052213.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS4D02G037400.1};
RN [1] {ECO:0000313|EMBL:KAF7052213.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7052213.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS4D02G037400.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS4D02G037400.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS4D02G037400.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7052213.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7052213.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR EMBL; CM022222; KAF7052213.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6JE47; -.
DR SMR; A0A3B6JE47; -.
DR STRING; 4565.A0A3B6JE47; -.
DR EnsemblPlants; TraesCS4D02G037400.1; TraesCS4D02G037400.1; TraesCS4D02G037400.
DR Gramene; TraesCAD_scaffold_101865_01G000300.1; TraesCAD_scaffold_101865_01G000300.1; TraesCAD_scaffold_101865_01G000300.
DR Gramene; TraesCLE_scaffold_169831_01G000200.1; TraesCLE_scaffold_169831_01G000200.1; TraesCLE_scaffold_169831_01G000200.
DR Gramene; TraesCS4D02G037400.1; TraesCS4D02G037400.1; TraesCS4D02G037400.
DR Gramene; TraesCS4D03G0062900.1; TraesCS4D03G0062900.1.CDS; TraesCS4D03G0062900.
DR Gramene; TraesPAR_scaffold_155352_01G000200.1; TraesPAR_scaffold_155352_01G000200.1; TraesPAR_scaffold_155352_01G000200.
DR Gramene; TraesROB_scaffold_133130_01G000200.1; TraesROB_scaffold_133130_01G000200.1; TraesROB_scaffold_133130_01G000200.
DR OMA; MTGSCET; -.
DR Proteomes; UP000019116; Chromosome 4D.
DR Proteomes; UP000815260; Chromosome 4D.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0051603; P:proteolysis involved in protein catabolic process; IBA:GO_Central.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR PANTHER; PTHR12411:SF814; PEPTIDASE C1A PAPAIN C-TERMINAL DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..328
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5039992191"
FT DOMAIN 37..93
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 123..327
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 328 AA; 35623 MW; AE6F58AA8992FC25 CRC64;
MAIPKALHLA ILGCICLCSS TVLSARELGD VSMVERHEQW MVKYNHVYKD DAEKAQRFEV
FKANVAFIES FNVGNHKFLL GVNQFTDLTN DEFRATKTNK GLKRSGGRAP TGFKYSNVST
DALPTVVDWR TKGVVTPIKD QGQCGIVKLS TGKLISLSKQ ELVDCDIHGV DQGCEGGEMD
DAFKFIIKNG GLTTESNYPY MAQDGQCKTS IASNSVATIK GYEDVPANDE SSLMKVVANQ
PVSVAVDGGD VIFQHYSGGV MTGSCGTDLD HGIAAIGYGM TSDGTKYWLL KNSWGTTWGE
NGYLRMKKDI SDKSGMCGLA MQPSYPTE
//
