ID A0A3B6JEI1_WHEAT Unreviewed; 995 AA.
AC A0A3B6JEI1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Protein HIRA {ECO:0000256|RuleBase:RU364014};
GN ORFNames=CFC21_060055 {ECO:0000313|EMBL:KAF7051863.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS4D02G008400.1};
RN [1] {ECO:0000313|EMBL:KAF7051863.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7051863.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS4D02G008400.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS4D02G008400.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS4D02G008400.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7051863.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7051863.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000256|RuleBase:RU364014}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364014}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306, ECO:0000256|RuleBase:RU364014}.
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DR EMBL; CM022222; KAF7051863.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6JEI1; -.
DR STRING; 4565.A0A3B6JEI1; -.
DR PaxDb; 4565-Traes_4DS_AAA25A43E-2; -.
DR EnsemblPlants; TraesCS4D02G008400.1; TraesCS4D02G008400.1; TraesCS4D02G008400.
DR Gramene; TraesCS4D02G008400.1; TraesCS4D02G008400.1; TraesCS4D02G008400.
DR Gramene; TraesCS4D03G0014600.1; TraesCS4D03G0014600.1.CDS; TraesCS4D03G0014600.
DR Gramene; TraesKAR4D01G0003450.1; cds.TraesKAR4D01G0003450.1; TraesKAR4D01G0003450.
DR OMA; DIQDMAW; -.
DR OrthoDB; 5478541at2759; -.
DR Proteomes; UP000019116; Chromosome 4D.
DR Proteomes; UP000815260; Chromosome 4D.
DR GO; GO:0000417; C:HIR complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50960; TolB, C-terminal domain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853,
KW ECO:0000256|RuleBase:RU364014}; Nucleus {ECO:0000256|RuleBase:RU364014};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364014};
KW Repressor {ECO:0000256|RuleBase:RU364014};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364014};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364014};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 9..50
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 62..103
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 121..162
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 163..204
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 685..882
FT /note="Protein HIRA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07569"
FT REGION 449..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 955..995
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 970..995
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 995 AA; 109174 MW; 41D76B10460AF1FF CRC64;
MLTEKPSWVR HDGLQIFSID IQPSGLRFAT GGGDQKVRIW NMKSVSKDNQ NDDSNQRLLA
TMRDHFGSVN CVRWAKHGRY LASGSDDQAI LIHERKAGSG TSEFGSGEPA DIENWKVVMT
LRGHTADVVD LNWSPDDSTL ASGSLDNTVH IWSMTNGICT AVLRGHSSLV KGVTWDPIGS
FIASQSDDKT VIIWRTSDWS LAHKTEGHWS KSLGSTFFRR LAWSPCGHFI TTTHGFQKPR
HSAPVLERGE WTATFDFLGH NAPVVVVKFN HSMFRKNLAT GQDAKTAPAG WANGASKTSA
KEYQPYNVIA IGSQDRTITV WTTAGARPLF VAKHFFTQSV VDLSWSPDGY SLFACSLDGS
VATFHFEAKE LGYRLSDSEL DELKRSRYGD VRGRQSNLAE SPAQLLLEEA SVKQLAAKKA
TPIVQQYQAP PKVPADVPKP PPVVVVESQK APETLPEGEK KTAGQAADDT SKVTRVSSPV
KQREYRRPDG RKRIIPEAVG FPSNQENLSN RPQNQVVDFS SLDQRMRPGE NGIRSSYGTG
NCNNCGVRER SGITARANIS ESLVIQKAST GTGRDGRLSV EHTGSVVPGL LASSSELSIF
VFNKKDNDDS LPVCLEAKPV ERSAGDMIGL GGSFSTKETE IRCTKGTETL WSDRISGKVT
VLAGNANFWA VGCEDGCLQV YTKCGMRAMP AMMMGSSAVF IDCDDCWKLL LVTRRGLMYI
WDLNNRTCIL QDSLASLVTS PDEASTKDSG TVKVISAKFS RCGSPLVVLA TRHAFLYDMS
MKCWLRIADD CFPASNFSSS FSSTQGGELG KLQIDIGKFM ARKPVWSRVT DDGVQTRAHL
ETQLAASLAL KSSQEYRQCL LSYIRFLARE ADESRLREVC ESFLGPPMGM VGDVSTDANN
PSWDPDVLGM KKHKLLREDI LPSMATNRKV QRLLNEFMDL LSEYESVAEE NVDKMDVTPP
AAEAKVDKMD VTPPAADAKV DKMDVTPTEA KDTAA
//
