ID A0A3B6JHI2_WHEAT Unreviewed; 709 AA.
AC A0A3B6JHI2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Phospholipid-transporting ATPase {ECO:0000256|RuleBase:RU362033};
DE EC=7.6.2.1 {ECO:0000256|RuleBase:RU362033};
GN ORFNames=CFC21_061769 {ECO:0000313|EMBL:KAF7053992.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS4D02G176200.1};
RN [1] {ECO:0000313|EMBL:KAF7053992.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7053992.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS4D02G176200.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS4D02G176200.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS4D02G176200.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7053992.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7053992.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + phospholipidSide 1 = ADP + phosphate +
CC phospholipidSide 2.; EC=7.6.2.1;
CC Evidence={ECO:0000256|RuleBase:RU362033};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362033}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362033}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IV subfamily. {ECO:0000256|RuleBase:RU362033}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362033}.
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DR EMBL; CM022222; KAF7053992.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6JHI2; -.
DR STRING; 4565.A0A3B6JHI2; -.
DR PaxDb; 4565-Traes_4DL_2338677F8-1; -.
DR EnsemblPlants; TraesCS4D02G176200.1; TraesCS4D02G176200.1; TraesCS4D02G176200.
DR Gramene; TraesCAD_scaffold_044336_01G000200.1; TraesCAD_scaffold_044336_01G000200.1; TraesCAD_scaffold_044336_01G000200.
DR Gramene; TraesCLE_scaffold_114561_01G000100.1; TraesCLE_scaffold_114561_01G000100.1; TraesCLE_scaffold_114561_01G000100.
DR Gramene; TraesCS4D02G176200.1; TraesCS4D02G176200.1; TraesCS4D02G176200.
DR Gramene; TraesCS4D03G0436300.1; TraesCS4D03G0436300.1.CDS; TraesCS4D03G0436300.
DR Gramene; TraesPAR_scaffold_063019_01G000100.1; TraesPAR_scaffold_063019_01G000100.1; TraesPAR_scaffold_063019_01G000100.
DR Gramene; TraesROB_scaffold_073366_01G000100.1; TraesROB_scaffold_073366_01G000100.1; TraesROB_scaffold_073366_01G000100.
DR Gramene; TraesWEE_scaffold_033631_01G000200.1; TraesWEE_scaffold_033631_01G000200.1; TraesWEE_scaffold_033631_01G000200.
DR Proteomes; UP000019116; Chromosome 4D.
DR Proteomes; UP000815260; Chromosome 4D.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140326; F:ATPase-coupled intramembrane lipid transporter activity; IBA:GO_Central.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0045332; P:phospholipid translocation; IBA:GO_Central.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR006539; P-type_ATPase_IV.
DR InterPro; IPR032631; P-type_ATPase_N.
DR NCBIfam; TIGR01652; ATPase-Plipid; 1.
DR PANTHER; PTHR24092:SF181; PHOSPHOLIPID-TRANSPORTING ATPASE; 1.
DR PANTHER; PTHR24092; PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF16209; PhoLip_ATPase_N; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU362033};
KW Magnesium {ECO:0000256|RuleBase:RU362033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362033};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU362033};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Translocase {ECO:0000256|RuleBase:RU362033};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362033}.
FT TRANSMEM 164..182
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 382..403
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 442..463
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT DOMAIN 122..185
FT /note="P-type ATPase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16209"
FT REGION 1..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 709 AA; 78747 MW; DEACD5347891ABAC CRC64;
MRPDGKLPPP HPSLAPLPQR PQQATGTDMD PHARLPDPVP SPILKHSPSI SRSLRSAADT
SSVTFAADFR SPSKPESTSP SFDSFRTARS RPSSVSRSST RRSASERAGS QRDLRDEDAR
FVYINDAPRT NAPPAMFPDN SIRTSKYSVL TFIPRNLYEQ FHRVAYIYFL ILAVLNFVPQ
LLVLSKEAGV LPLAFVLGVT AVKDAYEDWR RHRSDKNENN RTASVLADGV FRPKRWKDIQ
VGDVVRLVAN ETLPCDMVLV STSDPTGVAY IQTINLDGES NLKTRYAKQE TMSTPPEALA
GVIKCEKPNR NIYGFLATVD LNGRRAISLG TSNVMLRGCE LKNTVWAIGV AVYTGRDTKV
VLNSSGAPSK RSRLETHMNR EIIALAVALV VLCSVVSLLA GIWMGDHVDQ LGIIPFFHKY
DYSGAAAHDD GRYNWYGTGA QVVFTFMSAV IQFQVMIPIG LIISMELIRV GQAYFMVQDN
RMFDEKSQAR FQCRALNINE DLGQIKYVFS DKTGTLTQNR MEFRCASVQG RDFSETDGGE
EDGHAVQADG VVLRPKTAVT TDPKLAALLK DGMGAKASRA RDLFLALATC NTIVPIVEDT
VNPAAKLVEY QGESPDEQAL VYAAAAYGHK LVERTSGHIV VDVFGTRQRY ELTTPPVYCK
IFASQFLTAW QPLVKLFCFV RISLHCLWLK FLFVCCHNDK YARLCCDRH
//
