ID   A0A3B6KHK5_WHEAT        Unreviewed;       375 AA.
AC   A0A3B6KHK5;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=UDP-glucose 4-epimerase {ECO:0000256|RuleBase:RU366046};
DE            EC=5.1.3.- {ECO:0000256|RuleBase:RU366046};
OS   Triticum aestivum (Wheat).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX   NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS5A02G183100.1};
RN   [1] {ECO:0000313|EnsemblPlants:TraesCS5A02G183100.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Chinese Spring
RC   {ECO:0000313|EnsemblPlants:TraesCS5A02G183100.1};
RX   PubMed=30115783; DOI=10.1126/science.aar7191;
RG   International wheat genome sequencing consortium (IWGSC);
RT   "Shifting the limits in wheat research and breeding using a fully annotated
RT   reference genome.";
RL   Science 361:EAAR7191-EAAR7191(2018).
RN   [2] {ECO:0000313|EnsemblPlants:TraesCS5A02G183100.1}
RP   IDENTIFICATION.
RG   EnsemblPlants;
RL   Submitted (OCT-2018) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC         Evidence={ECO:0000256|ARBA:ARBA00001911,
CC         ECO:0000256|RuleBase:RU366046};
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC       {ECO:0000256|RuleBase:RU366046}.
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. {ECO:0000256|ARBA:ARBA00007637, ECO:0000256|RuleBase:RU366046}.
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DR   AlphaFoldDB; A0A3B6KHK5; -.
DR   SMR; A0A3B6KHK5; -.
DR   STRING; 4565.A0A3B6KHK5; -.
DR   EnsemblPlants; TraesCS5A02G183100.1; TraesCS5A02G183100.1; TraesCS5A02G183100.
DR   Gramene; TraesCAD_scaffold_063023_01G000100.1; TraesCAD_scaffold_063023_01G000100.1; TraesCAD_scaffold_063023_01G000100.
DR   Gramene; TraesCLE_scaffold_004177_01G000100.1; TraesCLE_scaffold_004177_01G000100.1; TraesCLE_scaffold_004177_01G000100.
DR   Gramene; TraesCS5A02G183100.1; TraesCS5A02G183100.1; TraesCS5A02G183100.
DR   Gramene; TraesCS5A03G0484300.1; TraesCS5A03G0484300.1.CDS; TraesCS5A03G0484300.
DR   Gramene; TraesKAR5A01G0230800.1; cds.TraesKAR5A01G0230800.1; TraesKAR5A01G0230800.
DR   Gramene; TraesPAR_scaffold_024981_01G000100.1; TraesPAR_scaffold_024981_01G000100.1; TraesPAR_scaffold_024981_01G000100.
DR   Gramene; TraesROB_scaffold_026479_01G000100.1; TraesROB_scaffold_026479_01G000100.1; TraesROB_scaffold_026479_01G000100.
DR   Gramene; TraesWEE_scaffold_059000_01G000200.1; TraesWEE_scaffold_059000_01G000200.1; TraesWEE_scaffold_059000_01G000200.
DR   OMA; GCEGANA; -.
DR   OrthoDB; 49205at2759; -.
DR   UniPathway; UPA00214; -.
DR   Proteomes; UP000019116; Chromosome 5A.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   CDD; cd05247; UDP_G4E_1_SDR_e; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR005886; UDP_G4E.
DR   NCBIfam; TIGR01179; galE; 1.
DR   PANTHER; PTHR43725; UDP-GLUCOSE 4-EPIMERASE; 1.
DR   PANTHER; PTHR43725:SF1; UDP-GLUCOSE 4-EPIMERASE 4; 1.
DR   Pfam; PF16363; GDP_Man_Dehyd; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism {ECO:0000256|RuleBase:RU366046};
KW   Isomerase {ECO:0000256|RuleBase:RU366046};
KW   NAD {ECO:0000256|RuleBase:RU366046};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019116}.
FT   DOMAIN          24..349
FT                   /note="NAD(P)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF16363"
SQ   SEQUENCE   375 AA;  40490 MW;  E16FC6F83C1CB736 CRC64;
     MAVNGAANGS SAANGSSGPT RTVLVTGGAG YIGSHAVLQL LAAGFRAVVV DSLENSSELA
     VRRVAALAGD HARNLSFHKV DIRDEDALDA VFASTRFDAV IHFAGLKAVG ESVQKPLFYY
     DHNIAGTINL LKVMAAHECK KLVFSSSAAV YGSPKNSPCT EEFPLLPHNP YGRTKLMAEE
     ICRDIYRSDS EWRIILLRYF NPVGAHPSGY LGEDPRGVPN NLMPYVQQVA VGRRPSVTIF
     GNNYATKDGT GVRDYIHVLD LAEGHIAALR KLFDSSSNIG CEPYNLGTGK GTSVLEIVNA
     FEKASGKKIP LVIGQRRPGD AEILFAGTGK AERELNWKAK YGITEMCRDQ WNWASKNPYG
     YGSPDSTKQN GSNSH
//