ID A0A3B6KM73_WHEAT Unreviewed; 785 AA.
AC A0A3B6KM73;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Subtilisin-like protease {ECO:0008006|Google:ProtNLM};
GN ORFNames=CFC21_066915 {ECO:0000313|EMBL:KAF7060095.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS5A02G316000.1.cds1};
RN [1] {ECO:0000313|EMBL:KAF7060095.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7060095.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS5A02G316000.1.cds1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS5A02G316000.1.cds1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS5A02G316000.1.cds1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7060095.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7060095.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
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DR EMBL; CM022223; KAF7060095.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6KM73; -.
DR SMR; A0A3B6KM73; -.
DR EnsemblPlants; TraesCS5A02G316000.1; TraesCS5A02G316000.1.cds1; TraesCS5A02G316000.
DR Gramene; TraesCAD_scaffold_097802_01G000100.1; TraesCAD_scaffold_097802_01G000100.1; TraesCAD_scaffold_097802_01G000100.
DR Gramene; TraesCS5A02G316000.1; TraesCS5A02G316000.1.cds1; TraesCS5A02G316000.
DR Gramene; TraesCS5A03G0767200.1; TraesCS5A03G0767200.1.CDS1; TraesCS5A03G0767200.
DR Gramene; TraesKAR5A01G0317010.1; cds.TraesKAR5A01G0317010.1; TraesKAR5A01G0317010.
DR Gramene; TraesPAR_scaffold_108193_01G000100.1; TraesPAR_scaffold_108193_01G000100.1; TraesPAR_scaffold_108193_01G000100.
DR OMA; MAIRAHI; -.
DR OrthoDB; 11910at2759; -.
DR Proteomes; UP000019116; Chromosome 5A.
DR Proteomes; UP000815260; Chromosome 5A.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02120; PA_subtilisin_like; 1.
DR CDD; cd04852; Peptidases_S8_3; 1.
DR Gene3D; 2.60.40.2310; -; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 3.30.70.80; Peptidase S8 propeptide/proteinase inhibitor I9; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR034197; Peptidases_S8_3.
DR InterPro; IPR010259; S8pro/Inhibitor_I9.
DR InterPro; IPR037045; S8pro/Inhibitor_I9_sf.
DR InterPro; IPR045051; SBT.
DR InterPro; IPR041469; Subtilisin-like_FN3.
DR PANTHER; PTHR10795; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN; 1.
DR PANTHER; PTHR10795:SF595; SUBTILISIN-LIKE PROTEASE; 1.
DR Pfam; PF17766; fn3_6; 1.
DR Pfam; PF05922; Inhibitor_I9; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..785
FT /note="Subtilisin-like protease"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5039992687"
FT DOMAIN 41..124
FT /note="Inhibitor I9"
FT /evidence="ECO:0000259|Pfam:PF05922"
FT DOMAIN 150..598
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT DOMAIN 390..474
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 675..775
FT /note="Subtilisin-like protease fibronectin type-III"
FT /evidence="ECO:0000259|Pfam:PF17766"
FT ACT_SITE 156
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 233
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 560
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 785 AA; 81468 MW; 9C11DC5CC6D00014 CRC64;
MELTIPPPLV ALCLLLAITG PANAAMATPA EGLETERTSS YIVHVAPARA PRLPRRGLLA
TRPYGSFLRD HVPVEISRPA PRVLYSYAHA ATGFAARLTP RQATRLASSV SVLAVVPDAM
QELHTTLTPS FLGLSESSGL LPASNDAVDV VIGVIDTGVY PLGRASFAAD PSLPPPPRTF
RGGCVTTPEF NASAYCNGKL VGAKFFRKGH EAARGRRAVG ETVSLSPLDT EGHGTHIAST
AAGSAGPDAS FYGYGEGRAV GAAPGARIAV YKACWQGCAS SDVLAAFDEA IADGVDVISA
SLGTRKARKF YKDTTAVGAF HAVRKGIVVS ASAGNSGPVE STVVNVAPWF LTVGASTIDR
QFPAVVVLGN GETFTGTSLY TGKPLGATKL PLVYGGNVGS KTCEVGKLNP TMVAGKIVLC
DPGVNGRTEK GYAVKLAGGA GAVLGSEEAQ GGQARTSAHI LPASAVTFAA AEKIKKYLST
QAYPVGTIVF RGTVVGRSPP SPRMASFSSR GPSRLVPEIL KPDVTAPGVD ILAAWTGAVS
PSLLDGDMRR VQYNIMSGTS ISCPLVSGIA ALLRQARPKW SPAAIKSALM TTAYNVDSAG
GVVEDMSTGK ASTPFARGAG HVDPNRAADP GLVYDAGTED YITFLCALGY TTEQMAVFSA
GTNCSTRVGA AAAGDLNYPA FSALFGPDKR AITQHRVVRN VGSNARATYR PKITSPAGVH
VTVKPRKLQF SATQGTQEYA ITFAQRTFGN VTEKHTFGSI EWSDGKHSVT SPITITWPAS
QVADM
//
