ID A0A3B6LEX8_WHEAT Unreviewed; 855 AA.
AC A0A3B6LEX8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=phosphatidylinositol 3-kinase {ECO:0000256|ARBA:ARBA00012073};
DE EC=2.7.1.137 {ECO:0000256|ARBA:ARBA00012073};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS5B02G062000.3};
RN [1] {ECO:0000313|EnsemblPlants:TraesCS5B02G062000.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS5B02G062000.3};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS5B02G062000.3}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family.
CC {ECO:0000256|PIRNR:PIRNR000587, ECO:0000256|PROSITE-ProRule:PRU00880}.
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DR AlphaFoldDB; A0A3B6LEX8; -.
DR SMR; A0A3B6LEX8; -.
DR STRING; 4565.A0A3B6LEX8; -.
DR EnsemblPlants; TraesCS5B02G062000.3; TraesCS5B02G062000.3; TraesCS5B02G062000.
DR Gramene; TraesCS5B02G062000.3; TraesCS5B02G062000.3; TraesCS5B02G062000.
DR Gramene; TraesCS5B03G0154600.2; TraesCS5B03G0154600.2.CDS; TraesCS5B03G0154600.
DR Proteomes; UP000019116; Chromosome 5B.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005777; C:peroxisome; IBA:GO_Central.
DR GO; GO:0000407; C:phagophore assembly site; IBA:GO_Central.
DR GO; GO:0034271; C:phosphatidylinositol 3-kinase complex, class III, type I; IBA:GO_Central.
DR GO; GO:0034272; C:phosphatidylinositol 3-kinase complex, class III, type II; IBA:GO_Central.
DR GO; GO:0016303; F:1-phosphatidylinositol-3-kinase activity; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000045; P:autophagosome assembly; IBA:GO_Central.
DR GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR GO; GO:0036092; P:phosphatidylinositol-3-phosphate biosynthetic process; IBA:GO_Central.
DR GO; GO:0048015; P:phosphatidylinositol-mediated signaling; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd08397; C2_PI3K_class_III; 1.
DR CDD; cd00870; PI3Ka_III; 1.
DR CDD; cd00896; PI3Kc_III; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR002420; PI3K-type_C2_dom.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR008290; PI3K_Vps34.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF7; PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00792; PI3K_C2; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR PIRSF; PIRSF000587; PI3K_Vps34; 2.
DR SMART; SM00142; PI3K_C2; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51547; C2_PI3K; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRNR:PIRNR000587};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR000587};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000587};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000587}.
FT DOMAIN 61..219
FT /note="C2 PI3K-type"
FT /evidence="ECO:0000259|PROSITE:PS51547"
FT DOMAIN 316..491
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 575..840
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 855 AA; 97096 MW; BA7AB5DBB8920C5C CRC64;
MAAAAVGISR TSAAGAGSSN SSEFRFFLSC DISLPLTFRV LQAPIPPPAQ GAHSRSLPCP
LSPHPQISLV FSSDLPFSCF LADGLDKKVS ELFVECKLYI DGIQFGLPVN TRLESSGPPY
CWNELITLCT KYRDLTSLAQ LAFTVWDVSS GEGKSVVGGA TIFLFNSKKQ LKTGKQKLQL
WPQKEADGRV PTTTPGKVPK NERGEIERLE RLVNKYERGQ IQHVDWLDRL AFSAIDKVKE
KECERLENSF PSLVVEFCSF EHRVVFQESG ANFYAPTPVS LSNELVTVWD PELGRTNPSE
HKQLKLARSL TRGIIDKDLK PSSNERKSLQ RIIKCPPTRT ILPDEKQLVW KFRFSLMSEK
KALTKFLRSV DWSDIQEAKQ AVELIGRWET IDVADALELL SSDFKSEEVR AYAVSVLERA
DDEELQCYLL QLVQALRFER SDKSRLAHFL VNRALSNIEI ASFLRWYVVV ELHDHAYAKR
YYSTYDMLED EMMKMVARED GDEDGFRLWQ SLSRQTELTA QLCSIMKDVR NTRGNAEKKI
EKLRQLLSGV HSELTHFDEP IRSPLAPTLL LTGVVPQESS IFKSSLIPLR LTFKTANGGT
SKMIFKKGDD LRQDQLVIQM VSLMDRLLKL ENMDLHLTPY QVLATGQDEG MVEFIPSSPL
AQIISEHRSI TSYLQKFHPD EDGPFGITAQ CLETFIKSCA GYSVITYIMG VGDRHLDNLL
IRDDGCLFHV DFGFILGRDP KPFPPPMKLC KEMVEAMGGT ESQYYTRFKS YCCEAYNILR
NNSSLILNLF TLMERSSIPD ISAEENATLK VQEKFRLDLD DEEAIHFFQG LINDSVSALF
PQMVETIHRW AQYWR
//