ID A0A3B6LJT4_WHEAT Unreviewed; 421 AA.
AC A0A3B6LJT4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=ethanolamine-phosphate cytidylyltransferase {ECO:0000256|ARBA:ARBA00024221};
DE EC=2.7.7.14 {ECO:0000256|ARBA:ARBA00024221};
DE AltName: Full=CTP:phosphoethanolamine cytidylyltransferase {ECO:0000256|ARBA:ARBA00031473};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS5B02G143400.1};
RN [1] {ECO:0000313|EnsemblPlants:TraesCS5B02G143400.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS5B02G143400.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS5B02G143400.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
CC -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC -!- PATHWAY: Phospholipid metabolism; phosphatidylethanolamine
CC biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.
CC {ECO:0000256|ARBA:ARBA00024191}.
CC -!- SIMILARITY: Belongs to the cytidylyltransferase family.
CC {ECO:0000256|ARBA:ARBA00010101}.
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DR AlphaFoldDB; A0A3B6LJT4; -.
DR SMR; A0A3B6LJT4; -.
DR STRING; 4565.A0A3B6LJT4; -.
DR PaxDb; 4565-Traes_5BL_8E201CCCE-2; -.
DR EnsemblPlants; TraesCS5B02G143400.1; TraesCS5B02G143400.1; TraesCS5B02G143400.
DR Gramene; TraesCAD_scaffold_009591_01G000100.1; TraesCAD_scaffold_009591_01G000100.1; TraesCAD_scaffold_009591_01G000100.
DR Gramene; TraesCLE_scaffold_044280_01G000100.1; TraesCLE_scaffold_044280_01G000100.1; TraesCLE_scaffold_044280_01G000100.
DR Gramene; TraesCS5B02G143400.1; TraesCS5B02G143400.1; TraesCS5B02G143400.
DR Gramene; TraesCS5B03G0398100.1; TraesCS5B03G0398100.1.CDS; TraesCS5B03G0398100.
DR Gramene; TraesKAR5B01G0178570.1; cds.TraesKAR5B01G0178570.1; TraesKAR5B01G0178570.
DR Gramene; TraesPAR_scaffold_006603_01G000100.1; TraesPAR_scaffold_006603_01G000100.1; TraesPAR_scaffold_006603_01G000100.
DR Gramene; TraesROB_scaffold_058245_01G000100.1; TraesROB_scaffold_058245_01G000100.1; TraesROB_scaffold_058245_01G000100.
DR Gramene; TraesWEE_scaffold_033513_01G000100.1; TraesWEE_scaffold_033513_01G000100.1; TraesWEE_scaffold_033513_01G000100.
DR OMA; THPCETH; -.
DR OrthoDB; 5474784at2759; -.
DR UniPathway; UPA00558; UER00742.
DR Proteomes; UP000019116; Chromosome 5B.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0004306; F:ethanolamine-phosphate cytidylyltransferase activity; IBA:GO_Central.
DR GO; GO:0006646; P:phosphatidylethanolamine biosynthetic process; IBA:GO_Central.
DR CDD; cd02174; CCT; 1.
DR CDD; cd02173; ECT; 1.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR InterPro; IPR041723; CCT.
DR InterPro; IPR004821; Cyt_trans-like.
DR InterPro; IPR044608; Ect1/PCYT2.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR NCBIfam; TIGR00125; cyt_tran_rel; 2.
DR PANTHER; PTHR45780; ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE; 1.
DR PANTHER; PTHR45780:SF14; ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE; 1.
DR Pfam; PF01467; CTP_transf_like; 2.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 2.
PE 3: Inferred from homology;
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116}.
FT DOMAIN 59..188
FT /note="Cytidyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF01467"
FT DOMAIN 258..351
FT /note="Cytidyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF01467"
FT REGION 204..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..415
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 421 AA; 46652 MW; D4FFE5F222E9440F CRC64;
MEAGSSKARL AVACAIGGIV LGAAVVALHV AGPVAVPGLP PLDALRRRFH RRRRPVRVYM
DGCFDMMHYG HCNALRQARA LGDQLVVGVV SDDEITANKG PPVTPLNERM VMVGAVKWVD
DVIPDAPYAI TEDFMNKLFT EYNIDYIIHG DDPCLLPDGT DAYALAKNAG RYKQIKRTEG
VSTTDIVGRM LLCVRERSVS DRHNHSSLQR QFSSGHGQKI DDSGSGSGTR ISHFLPTSRR
IVQFSNSRGP GPDSRIVYID GAFDLFHAGH VEILRLARGL GDFLLVGIHT DQTISSTRGP
HRPIMNLHER SLSVLACRYV DEVIIGAPWD ISKDMITTFN ISLVVQGTIA ENMDFAKDES
HPYAVPMVMG IFRRLESPLD ITTSTIIRRI VSNHEAYQKR NEKKEASEKK YYESKNFVNG
E
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