ID A0A3B6LQB6_WHEAT Unreviewed; 949 AA.
AC A0A3B6LQB6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=NB-ARC domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CFC21_072618 {ECO:0000313|EMBL:KAF7066678.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS5B02G304900.1};
RN [1] {ECO:0000313|EMBL:KAF7066678.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7066678.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS5B02G304900.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS5B02G304900.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS5B02G304900.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7066678.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7066678.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR EMBL; CM022224; KAF7066678.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6LQB6; -.
DR STRING; 4565.A0A3B6LQB6; -.
DR EnsemblPlants; TraesCS5B02G304900.1; TraesCS5B02G304900.1; TraesCS5B02G304900.
DR Gramene; TraesCAD_scaffold_019419_01G000400.1; TraesCAD_scaffold_019419_01G000400.1; TraesCAD_scaffold_019419_01G000400.
DR Gramene; TraesCLE_scaffold_035560_01G000300.1; TraesCLE_scaffold_035560_01G000300.1; TraesCLE_scaffold_035560_01G000300.
DR Gramene; TraesCS5B02G304900.1; TraesCS5B02G304900.1; TraesCS5B02G304900.
DR Gramene; TraesCS5B03G0777800.1; TraesCS5B03G0777800.1.CDS; TraesCS5B03G0777800.
DR Gramene; TraesKAR5B01G0320500.1; cds.TraesKAR5B01G0320500.1; TraesKAR5B01G0320500.
DR Gramene; TraesPAR_scaffold_033185_01G000200.1; TraesPAR_scaffold_033185_01G000200.1; TraesPAR_scaffold_033185_01G000200.
DR Gramene; TraesROB_scaffold_024688_01G000200.1; TraesROB_scaffold_024688_01G000200.1; TraesROB_scaffold_024688_01G000200.
DR Gramene; TraesWEE_scaffold_007199_01G000200.1; TraesWEE_scaffold_007199_01G000200.1; TraesWEE_scaffold_007199_01G000200.
DR OMA; SGCACEF; -.
DR Proteomes; UP000019116; Chromosome 5B.
DR Proteomes; UP000815260; Chromosome 5B.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1232; OS09G0517200 PROTEIN; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116}.
FT DOMAIN 13..101
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 181..397
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 949 AA; 107031 MW; AAF037B7D2CAFBD5 CRC64;
MEATAVSLTR TVLDGVLGSA GTAMADEAAL LLGVRREVGF IRSELQMMQS FLRVQSSATR
WGAGGGGCRD TVRTCVKQVR DLACDLEDCL LDFTLHASRS RWLRWGPGLV ARHRLAGRIR
GLKATVVELN QRNKRYNVFA AASHHGVTPG EEHHGHADDD YPRAQLAPGN ERQDIERAGE
MDELVRLVNK MGDAWVVSVW GMGGMGKSSL VRMLYNDMAL IDGFDGRAWV TVPHPLESAD
EVERRLRKQL GVAPDRSVRA WLVENRCLVV VDDVSSHEEW ELISRCLPAN GPTGSRVVVT
TRRDDVARQC AGDVRENVYE LKPLEDEEAR KLFCQKVYKD AGYKLMDDMM EQASRILERC
RGLPLAIATI GGLLANRPKT SREWMDLRKH LGSELESDRD IKRVITSSYD GLPYHLKCCF
LYLSIFPENH EIRLTRLLRR WIAEGYITKP RDMSVEELGR RYYNELISRS MIQPSEKARA
SMAVERCRVH GVVLQIILSQ SIEENQLFIM DKHCNEAPQS NIRHLVVTRW KKNEKMASLN
LSQVRSLTIF GRCPVSLISS KLHLLRVLDL EDTLELENDD LKHIGELHHL RYLGLRKTNI
SSLPSSLENL RFLETLDVQD TKVTQLPFGI TKLEKLCHLV GGVNFAKDLA GKTKRNKETG
KCNGDPFETF ADLVTGCYGY KQVEPSCSCC ACEFSVTAPE RIEKLRNLQV LGVVHIARGS
KVARNLGELT SLRRLGVEVD ATEEVGKDLC GSISRLVRLE RLEVRSRSLE FLKEAEKAEE
MPPKHLLSLR LCGRLGNLPG WMDRLNDLAK VKLIQTQLKQ VDIEVMGKLR NLTLLALWEE
SFAEKTLCFG EGTFPKLKLL YIEGMENIVT IQIKDGALPV LEKLEVKKCV NLDDSKEGLS
LVLVLQNLNE LVLTSCGDKP KLEKELQKQI SGFKKRPKFI TGRSIVSRS
//
