ID A0A3B6LYL1_WHEAT Unreviewed; 549 AA.
AC A0A3B6LYL1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Tyrosine N-monooxygenase {ECO:0008006|Google:ProtNLM};
GN ORFNames=CFC21_075094 {ECO:0000313|EMBL:KAF7069467.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS5B02G548700.1};
RN [1] {ECO:0000313|EMBL:KAF7069467.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7069467.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS5B02G548700.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS5B02G548700.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS5B02G548700.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7069467.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7069467.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971};
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR EMBL; CM022224; KAF7069467.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6LYL1; -.
DR SMR; A0A3B6LYL1; -.
DR STRING; 4565.A0A3B6LYL1; -.
DR EnsemblPlants; TraesCS5B02G548700.1; TraesCS5B02G548700.1; TraesCS5B02G548700.
DR Gramene; TraesCLE_scaffold_095198_01G000100.1; TraesCLE_scaffold_095198_01G000100.1; TraesCLE_scaffold_095198_01G000100.
DR Gramene; TraesCS5B02G548700.1; TraesCS5B02G548700.1; TraesCS5B02G548700.
DR Gramene; TraesCS5B03G1308600.1; TraesCS5B03G1308600.1.CDS; TraesCS5B03G1308600.
DR Proteomes; UP000019116; Chromosome 5B.
DR Proteomes; UP000815260; Chromosome 5B.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR CDD; cd20658; CYP79; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR47949; CYTOCHROME P450 703A2-RELATED-RELATED; 1.
DR PANTHER; PTHR47949:SF4; CYTOCHROME P450 FAMILY PROTEIN; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|RuleBase:RU000461}; Iron {ECO:0000256|RuleBase:RU000461};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Metal-binding {ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
SQ SEQUENCE 549 AA; 60660 MW; B2136946DA1DCD70 CRC64;
MGKMGASLSS ATAKALVLVL AFINLAVQRL LLLRRPKSKI ASSAGGRSSI TNATSAAALP
PGPVPWPVVG NLPEMLFNKP VFRWIHQMME KMGTDIACVR LGGVHVIAVT CPSIAREVLR
KQDANFASRP LTFASSAFSG GYKNAVLSPF GDQWKKMRRV LTSEIVCPSR HRWLHDRRAG
EADNLTRYVY ALTMGSASAS GVDVRHVARH YCGNVIRSLV FGRRYFGEPQ PNGGPGPMEV
EHMDAVFRSM GLLFAFCISD YLPWLRGLDL DGQEKMVKEA NATVNRLHDT VIDERWRQWK
SGERRELDDF LDVLITLEDA EGKPLLAIEE VKAQSQDITF AAVDNPSNAV EWALAEMANA
PEVMAKAMEE MDRVVGRERL VQESDIPHLN YAKACIREAF RLHPVAPFNV PHVALADTTV
AGYHVPKGSH VILSRSGLGR NPTIWDEPLC FKPERHINMD DGGNVVLTEN ELRFISFSTG
RRGCIASSLG TATCVMLFGR LLQGFTWSKP PGLSAIDLSE SEHDLFMAKP LVLHAELRLP
MHLYSATDI
//
