ID A0A3B6MK84_WHEAT Unreviewed; 564 AA.
AC A0A3B6MK84;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Sodium/calcium exchanger membrane region domain-containing protein {ECO:0000259|Pfam:PF01699};
GN ORFNames=CFC21_075688 {ECO:0000313|EMBL:KAF7070136.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS5D02G030700.1.cds1};
RN [1] {ECO:0000313|EMBL:KAF7070136.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7070136.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS5D02G030700.1.cds1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS5D02G030700.1.cds1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS5D02G030700.1.cds1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7070136.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7070136.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. Cation/calcium exchanger (CCX) subfamily.
CC {ECO:0000256|ARBA:ARBA00038187}.
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DR EMBL; CM022225; KAF7070136.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6MK84; -.
DR STRING; 4565.A0A3B6MK84; -.
DR PaxDb; 4565-Traes_5DS_8E70396F8-1; -.
DR EnsemblPlants; TraesCS5D02G030700.1; TraesCS5D02G030700.1.cds1; TraesCS5D02G030700.
DR Gramene; TraesCAD_scaffold_082682_01G000100.1; TraesCAD_scaffold_082682_01G000100.1; TraesCAD_scaffold_082682_01G000100.
DR Gramene; TraesCS5D02G030700.1; TraesCS5D02G030700.1.cds1; TraesCS5D02G030700.
DR Gramene; TraesCS5D03G0076000.1; TraesCS5D03G0076000.1.CDS1; TraesCS5D03G0076000.
DR Gramene; TraesKAR5D01G0022550.1; cds.TraesKAR5D01G0022550.1; TraesKAR5D01G0022550.
DR Gramene; TraesPAR_scaffold_134094_01G000100.1; TraesPAR_scaffold_134094_01G000100.1; TraesPAR_scaffold_134094_01G000100.
DR Gramene; TraesRN5D0100081100.1; TraesRN5D0100081100.1; TraesRN5D0100081100.
DR Gramene; TraesWEE_scaffold_078269_01G000100.1; TraesWEE_scaffold_078269_01G000100.1; TraesWEE_scaffold_078269_01G000100.
DR OMA; VKQPIDM; -.
DR OrthoDB; 420288at2759; -.
DR Proteomes; UP000019116; Chromosome 5D.
DR Proteomes; UP000815260; Chromosome 5D.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006812; P:monoatomic cation transport; IBA:GO_Central.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR PANTHER; PTHR12266; NA+/CA2+ K+ INDEPENDENT EXCHANGER; 1.
DR PANTHER; PTHR12266:SF32; SODIUM_CALCIUM EXCHANGER MEMBRANE REGION DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01699; Na_Ca_ex; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 108..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 182..207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 389..408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 414..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..489
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 501..521
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 533..557
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 115..261
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT DOMAIN 395..547
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
SQ SEQUENCE 564 AA; 58187 MW; DE113F94027F5840 CRC64;
MAFLQRLYKR RRNAAAVTAS ASFLLLLLVL CLSLRTRHGG TFFFGSGAGA RERGSCEAEL
QALEGRAARC RYLRSSSHPP CAPTGYVDYL ALFYCACGEQ EGLWWSPWLG GAAIALWLLL
LFYLLGDTAS EYFCASLEGL SAALRLPPAV AGVTLLSLGN GAPDVLSSVV AFASDGGEAG
DVGLSGALGG ALFVSTVVAG VVAIVAARRG GAVIERRGFV RDVCFLLVAL CYLLAVLVAG
TVTVWAAACF LSLYAAYVLL VSTSHCCSVA ADDGSTYTST KPSDDLAAPL LLPVAVSSKQ
PPRTFASGLL AAVHAPLYLP RRLTIPDIAA HRWSRPCAIT STLLGPLLLA VVTSPTSPTV
LLAGALTGTL FAIAAAATTD AAAPPHGRYV RLLWLAGGFL MSILWSYLLA RELVALLVST
GIIVGVPASV LGVTVLAWGN SLGDMVADVA MATQDGASGA QTAVAGCYAG PAFNTVVGLG
LSMALAAGAR YPETYKIPVD AATYVTVAFL VAGLAWALVV LPARGMRLDA TLGAGLLAVY
LCFIAVRVAD AVGVLSLDSL LPRL
//
