ID A0A3B6MN95_WHEAT Unreviewed; 734 AA.
AC A0A3B6MN95;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Translation initiation factor eIF2B subunit epsilon {ECO:0000256|ARBA:ARBA00044144};
DE AltName: Full=eIF2B GDP-GTP exchange factor subunit epsilon {ECO:0000256|ARBA:ARBA00044345};
GN ORFNames=CFC21_076259 {ECO:0000313|EMBL:KAF7070799.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS5D02G088300.1};
RN [1] {ECO:0000313|EMBL:KAF7070799.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7070799.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS5D02G088300.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS5D02G088300.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS5D02G088300.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7070799.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7070799.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the eIF-2B gamma/epsilon subunits family.
CC {ECO:0000256|ARBA:ARBA00007878}.
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DR EMBL; CM022225; KAF7070799.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6MN95; -.
DR SMR; A0A3B6MN95; -.
DR STRING; 4565.A0A3B6MN95; -.
DR EnsemblPlants; TraesCS5D02G088300.1; TraesCS5D02G088300.1; TraesCS5D02G088300.
DR Gramene; TraesCAD_scaffold_020484_01G000300.1; TraesCAD_scaffold_020484_01G000300.1; TraesCAD_scaffold_020484_01G000300.
DR Gramene; TraesCLE_scaffold_052192_01G000100.1; TraesCLE_scaffold_052192_01G000100.1; TraesCLE_scaffold_052192_01G000100.
DR Gramene; TraesCS5D02G088300.1; TraesCS5D02G088300.1; TraesCS5D02G088300.
DR Gramene; TraesCS5D03G0213400.5; TraesCS5D03G0213400.5.CDS; TraesCS5D03G0213400.
DR Gramene; TraesPAR_scaffold_089154_01G000200.1; TraesPAR_scaffold_089154_01G000200.1; TraesPAR_scaffold_089154_01G000200.
DR Gramene; TraesROB_scaffold_017381_01G000300.1; TraesROB_scaffold_017381_01G000300.1; TraesROB_scaffold_017381_01G000300.
DR Gramene; TraesWEE_scaffold_058676_01G000300.1; TraesWEE_scaffold_058676_01G000300.1; TraesWEE_scaffold_058676_01G000300.
DR Proteomes; UP000019116; Chromosome 5D.
DR Proteomes; UP000815260; Chromosome 5D.
DR GO; GO:0005851; C:eukaryotic translation initiation factor 2B complex; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR GO; GO:0031369; F:translation initiation factor binding; IBA:GO_Central.
DR CDD; cd04197; eIF-2B_epsilon_N; 1.
DR CDD; cd05787; LbH_eIF2B_epsilon; 1.
DR CDD; cd11558; W2_eIF2B_epsilon; 1.
DR Gene3D; 1.25.40.180; -; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035543; eIF-2B_epsilon_N.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR003307; W2_domain.
DR InterPro; IPR044123; W2_eIF2B_epsilon.
DR PANTHER; PTHR45887:SF2; EIF-2B GDP-GTP EXCHANGE FACTOR SUBUNIT EPSILON; 1.
DR PANTHER; PTHR45887; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR Pfam; PF02020; W2; 1.
DR SMART; SM00515; eIF5C; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR PROSITE; PS51363; W2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000019116}.
FT DOMAIN 560..730
FT /note="W2"
FT /evidence="ECO:0000259|PROSITE:PS51363"
FT REGION 439..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 530..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..473
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 532..552
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 734 AA; 82120 MW; 119956EFAEA886DD CRC64;
MSQKKSRGGA AAREDADELS RSPLQAVLLA DSFTLKFRPI TLERPKVLLP LVNVPMIDYT
LSWLETEGVE EVFVFCCAHA QQVKEHLEEA GWTGKPAAWE MAVMAVESHD AISAGDALRV
MYGRGLINGD FVLISGDTIS NMSLKEVLQE HKDRRKKDPL AVMTMIIKHS KPSILMHQTR
LGTDEIVMAL ASETKELLYY EDRADSSHLC VTIDKDILAN NPTLQLHNNM EDCYIDICSP
DVLSLFTDNF DYQHLRRHFV KGLLVDDIMG YKIYTHEIHS SYAARIDNFR SYDAVSKDII
QRWTYPMVPD VLSFGNCHEM KLHRQGIYKA SDVTLSHSAQ IGANSVIGNA TSIGEQCKIL
NSVIGEGCSI GKNVLIHGSY IWDNVIIEDG CKVSNSLVCD DVHLRAGAIV EPGCILSFKI
KVGKNVVVPA YSKVSLLDKP SNEDSDEELE YADTNSGVTD SAPFSSTRGN ADHPTIVSED
DELGASETCT SGVLGYIWAS GDTGILEEWR QSIAPIPKEK LQELQHAVSV DGDVGSEEDL
NNRPSEADRD NDSEIGVIED DDYTKFEKEV EETFQRAVDG VHQDNLILEI NALRLSYSLQ
HADCAGAVFY SIMRAALVAA QSTNDSLLKS TADALTKWKD LLRNYTKTVD EEMEILLKFE
EMCQEITKEF SPLFSKILPY LYDKEIVSEV AILRWAEEKE NADEPDKVFV KQSDVFIQWL
KEAEEEDEDD EEEE
//