ID A0A3B6MP99_WHEAT Unreviewed; 157 AA.
AC A0A3B6MP99;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=HIT domain-containing protein {ECO:0000259|PROSITE:PS51084};
GN ORFNames=CFC21_076921 {ECO:0000313|EMBL:KAF7071653.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS5D02G147300.1};
RN [1] {ECO:0000313|EMBL:KAF7071653.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7071653.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS5D02G147300.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS5D02G147300.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS5D02G147300.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7071653.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7071653.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CM022225; KAF7071653.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6MP99; -.
DR SMR; A0A3B6MP99; -.
DR STRING; 4565.A0A3B6MP99; -.
DR PaxDb; 4565-Traes_5DL_FEA30FE3D-1; -.
DR EnsemblPlants; TraesCS5D02G147300.1; TraesCS5D02G147300.1; TraesCS5D02G147300.
DR Gramene; TraesCAD_scaffold_039491_01G000300.1; TraesCAD_scaffold_039491_01G000300.1; TraesCAD_scaffold_039491_01G000300.
DR Gramene; TraesCLE_scaffold_115825_01G000300.1; TraesCLE_scaffold_115825_01G000300.1; TraesCLE_scaffold_115825_01G000300.
DR Gramene; TraesCS5D02G147300.1; TraesCS5D02G147300.1; TraesCS5D02G147300.
DR Gramene; TraesCS5D03G0368300.1; TraesCS5D03G0368300.1.CDS; TraesCS5D03G0368300.
DR Gramene; TraesPAR_scaffold_029243_01G000300.1; TraesPAR_scaffold_029243_01G000300.1; TraesPAR_scaffold_029243_01G000300.
DR Gramene; TraesRN5D0100384800.1; TraesRN5D0100384800.1; TraesRN5D0100384800.
DR Gramene; TraesROB_scaffold_036218_01G000300.1; TraesROB_scaffold_036218_01G000300.1; TraesROB_scaffold_036218_01G000300.
DR Gramene; TraesWEE_scaffold_110711_01G000100.1; TraesWEE_scaffold_110711_01G000100.1; TraesWEE_scaffold_110711_01G000100.
DR OMA; QVVHQFI; -.
DR Proteomes; UP000019116; Chromosome 5D.
DR Proteomes; UP000815260; Chromosome 5D.
DR GO; GO:0047627; F:adenylylsulfatase activity; IEA:UniProt.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR CDD; cd01275; FHIT; 1.
DR Gene3D; 3.30.428.10; HIT-like; 1.
DR InterPro; IPR039383; FHIT.
DR InterPro; IPR019808; Histidine_triad_CS.
DR InterPro; IPR001310; Histidine_triad_HIT.
DR InterPro; IPR011146; HIT-like.
DR InterPro; IPR036265; HIT-like_sf.
DR PANTHER; PTHR46243; BIS(5'-ADENOSYL)-TRIPHOSPHATASE; 1.
DR PANTHER; PTHR46243:SF1; BIS(5'-ADENOSYL)-TRIPHOSPHATASE; 1.
DR Pfam; PF01230; HIT; 1.
DR PRINTS; PR00332; HISTRIAD.
DR SUPFAM; SSF54197; HIT-like; 1.
DR PROSITE; PS00892; HIT_1; 1.
DR PROSITE; PS51084; HIT_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116}.
FT DOMAIN 4..112
FT /note="HIT"
FT /evidence="ECO:0000259|PROSITE:PS51084"
FT COILED 128..155
FT /evidence="ECO:0000256|SAM:Coils"
FT MOTIF 97..101
FT /note="Histidine triad motif"
FT /evidence="ECO:0000256|PIRSR:PIRSR601310-3,
FT ECO:0000256|PROSITE-ProRule:PRU00464"
FT ACT_SITE 99
FT /note="Tele-AMP-histidine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR601310-1"
FT BINDING 30
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
FT BINDING 86
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
FT BINDING 92..95
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
FT BINDING 101
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
FT SITE 117
FT /note="Important for induction of apoptosis"
FT /evidence="ECO:0000256|PIRSR:PIRSR639383-3"
SQ SEQUENCE 157 AA; 18086 MW; E4D580FC9883FA40 CRC64;
MEASAYKFGP YRIDAREVFH ATPLSYAMVN LRPLLPGHVL VCPKREVKRF TDLSTDETSD
LWVTAKEVGV RLEQYHKASS LTFAIQDGPQ AGQTVPHVHI HVIPRKKGDF ENNDEIYDAI
DVKEKELKEK LDLDVERKDR TMEEMSHEAN EYRALFS
//
